Junling Gao

Metagenomic next-generation sequencing for the etiological diagnosis of rabies virus in cerebrospinal fluid

Yong Liu, Xichao Mo, Ye Feng, Rodney E. Willoughby et autres

Background: Rabies is a highly fatal disease. Once symptoms develop, death usually occurs within days. Survivors were occasionally reported in the literatures. Ante-mortem diagnosis remains a challenge in most rabies endemic countries. A novel, accurate diagnostic assay is highly desirable. Methods: We …

cn, us, hk (code pays fourni par la source)

Correction: Role of microglia in the dissemination of Zika virus from mother to fetal brain

Pei Xu, Chao Shan, Tiffany Dunn, Xuping Xie et autres

[This corrects the article DOI: 10.1371/journal.pntd.0008413.].

Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells

Pei Xu, Junling Gao, Chao Shan, Tiffany Dunn et autres

Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. …

us (code pays fourni par la source)

Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury

Shiqing Feng, Ping Wu, Wenye Song, Han Ding et autres

Metformin, a first-line drug for type-2 diabetes, has been shown to improve locomotor recovery after spinal cord injury. However, there are studies reporting no beneficial effect. Recently, we found that high dose of metformin (200 mg/kg, intraperitoneal) and acute phase administration (immediately …

cn, us (code pays fourni par la source)

Role of microglia in the dissemination of Zika virus from mother to fetal brain

Pei Xu, Chao Shan, Tiffany Dunn, Xuping Xie et autres

Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model …

us (code pays fourni par la source)

Peli1 signaling blockade attenuates congenital zika syndrome

Guangyu Li, Binbin Wang, Bing Tian, Junling Gao et autres

Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in …

us (code pays fourni par la source)

Chronic poly-drug administration damages adult mouse brain neural stem cells

Erica L. McGrath, Caitlin R. Schlagal, Ibdanelo Cortez, Tiffany Dunn et autres

us (code pays fourni par la source)

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Joy Mitra, Erika N. Guerrero, Pavana M. Hegde, Nicole F. Liachko et autres

Significance Amyotrophic lateral sclerosis (ALS) is a devastating, motor neuron degenerative disease without any cure to date. About 95% of ALS patients feature abnormalities in the RNA/DNA binding protein TDP-43, involving its nucleus-cytoplasmic mislocalization in spinal motor neurons. How TDP-43 pathology triggers …

us, in, pa (code pays fourni par la source)

Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines

Brian E. Dawes, Junling Gao, Colm Atkins, Jacob Nelson et autres

BACKGROUND: La Crosse virus (LACV) causes pediatric encephalitis in the USA. LACV induces severe inflammation in the central nervous system, but the recruitment of inflammatory cells is poorly understood. A deeper understanding of LACV-induced neural pathology is needed in order to develop …

us (code pays fourni par la source)

Oligodendrocyte differentiation from human neural stem cells: A novel role for c-Src

Le Wang, Caitlin R. Schlagal, Junling Gao, Yan Hao et autres

cn, us (code pays fourni par la source)

Adult Neural Stem Cells Show Regional and Sex‐Dependent Responses to Chronic Poly‐Drug Administration

Caitlin R. Schlagal, Erica L. McGrath, Junling Gao, Tiffany Dunn et autres

Cocaine use disorder (CUD) and alcohol use disorder (AUD) are highly prevalent substance use disorders in the US. Cocaine and alcohol co‐abuse is the third most lethal substance combination and affects 12 million Americans annually. Interestingly, it has been reported that females …

us (code pays fourni par la source)

Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis

Erica L. McGrath, Junling Gao, Ping Wu

Human fetal brain neural stem cells are a unique non-genetically modified model system to study the impact of various stimuli on human developmental neurobiology. Rather than use an animal model or genetically modified induced pluripotent cells, human neural stem cells provide an …

us, cn (code pays fourni par la source)