Daniel Felsky

Assessment of noninvasive quantification of [18F]SynVesT-1 with simplified reference tissue model 2 in an adolescent and youth cohort

Carme Uribe, Lucas Narciso, Sang Soo Cho, Maia Zilberman et autres

PURPOSE: The suitability of the white matter centrum semiovale (CS) as a pseudo-reference region for simplified reference tissue model 2 (SRTM2) with [¹⁸F]SynVesT-1 PET has not been evaluated in youth cohorts. We aimed to assess noninvasive quantification methods and determine the minimum …

ca, us (code pays fourni par la source)

Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts

Tara Lynn Henechowicz, Peyton L. Coleman, Daniel E. Gustavson, Yasmina Mekki et autres

Active music engagement, that is, playing a musical instrument or singing, may be protective of motor function decline in aging. Although playing a musical instrument may transfer to benefits in motor function, it is also possible that the genetic architecture of motor …

ca, us (code pays fourni par la source)

Evaluating biomarkers and prediction models with E2P Simulator

Povilas Karvelis, Daniel Felsky, Anissa Abi-Dargham, Guillermo Horga et autres

Precision psychiatry aims to identify biomarkers and develop prediction models to improve diagnosis, prognosis, and treatment selection. Despite extensive research, translating findings into clinically useful tools remains challenging. Here we argue that one key contributor to this translational gap is a pervasive …

Evaluating biomarkers and prediction models with E2P Simulator

Anissa Abi-Dargham, Guillermo Horga, Andreea Cristina Andreea, Daniel Felsky et autres

Precision psychiatry aims to identify biomarkers and develop prediction models to improve diagnosis, prognosis, and treatment selection. Despite extensive research, translating findings into clinically useful tools remains challenging. Here we argue that one key contributor to this translational gap is a pervasive …

Editorial: Preserving emotional health in aging: unraveling the neural mechanisms and implications for neurodegenerative diseases

Quelen Iane Garlet, Daniel Felsky, Kiyotaka Nemoto

Day-to-day functioning in late life depends on preserving cognition and emotional health. Emotional resilience emerges as a cornerstone for longevity, requiring synergy among modifiable factors such as physical activity, social networks, education, and psychological well-being. Self-reported hopefulness is positively associated with healthy …

br, ca, jp (code pays fourni par la source)

GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging

Tara Lynn Henechowicz, Brooke Wolford, Rachana Nitin, Yasmina Mekki et autres

ca, us, no (code pays fourni par la source)

Digital Twins in Late-life Neurodegeneration Prevention, Diagnosis, and Care: A State-of-the-Art Review

Megan Bokenfohr, Mackenzie Hilton, Laura Sikstrom, Maurizio De Pitta et autres

Background & Rationale The rise of digital health technologies presents a transformative opportunity to enhance the clinical care pathway for late-life neurodegeneration diseases including Alzheimer’s, Parkinson’s, and dementia.(1) Among them, digital twins, virtual models of individual patients created from real-world medical and …

Predictors of past 30-day vaping abstinence among young e-cigarette users: Machine learning analysis of a longitudinal cohort

Anasua Kundu, Peter Selby, Daniel Felsky, Theo J. Moraes et autres

ca (code pays fourni par la source)

Evaluating biomarkers and prediction models with E2P Simulator

Povilas Karvelis, Daniel Felsky, Anissa Abi-Dargham, Guillermo Horga et autres

Precision psychiatry aims to identify biomarkers and develop prediction models to improve diagnosis, prognosis, and treatment selection for mental illness. Despite extensive research, translating findings into clinically useful tools remains challenging. Here we argue that one key contributor to this translational gap …

Digital Twins in Late-life Neurodegeneration Prevention, Diagnosis, and Care: A State-of-the-Art Review

Daniel Felsky, Megan Bokenfohr, Nelson Shen, Maurizio De Pitta et autres

Background & Rationale The rise of digital health technologies presents a transformative opportunity to enhance the clinical care pathway for late-life neurodegeneration diseases including Alzheimer’s, Parkinson’s, and dementia.(1) Among them, digital twins, virtual models of individual patients created from real-world medical and …

Code-repository-2025

Tara Lynn Henechowicz, Daniel Felsky

Digital Twins in Late-life Neurodegeneration Prevention, Diagnosis, and Care: A State-of-the-Art Review

Maurizio De Pitta, Laura Sikstrom, Mackenzie Hilton, Nelson Shen et autres

Background & Rationale The rise of digital health technologies presents a transformative opportunity to enhance the clinical care pathway for late-life neurodegeneration diseases including Alzheimer’s, Parkinson’s, and dementia.(1) Among them, digital twins, virtual models of individual patients created from real-world medical and …