Rachana Nitin

13. DIRECT CRISPR-EDITING OF RS4702 DECIPHERS CELL-TYPE SPECIFIC EPISTATIC INTERACTIONS WITH SCHIZOPHRENIA POLYGENIC RISK

Kayla Retallick-Townsley, Kristina Rehbach, Carina Seah, Matthijs de Waal et autres

Background Schizophrenia (SCZ) has a complex, heterogeneous, and highly polygenic genetic architecture. Polygenic risk scores (PRS) assume additive genetic effects and may not capture epistatic or gene-by-environment interactions. However, PRS analyzed in conjunction with functional genomic approaches using CRISPR editing and stem …

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W95. BRIDGING CLINICAL PRACTICE AND RESEARCH: EXTRACTING DEVELOPMENTAL MILESTONES FROM THE ELECTRONIC HEALTH RECORDS AND IDENTIFYING SEX DIFFERENCES AND EARLY MARKERS OF NEURODEVELOPMENTAL DISORDERS

Maria Niarchou, Ellen Tsai, Rachana Nitin, Ky'Era Actkins et autres

Background Developmental milestones are routinely assessed during pediatric well-child visits and are critical for monitoring child development and identifying delays. Despite widespread collection, these data remain underutilized in research due to challenges in extraction and standardization from electronic health records (EHRs). In …

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Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts

Tara Lynn Henechowicz, Peyton L. Coleman, Daniel E. Gustavson, Yasmina Mekki et autres

Active music engagement, that is, playing a musical instrument or singing, may be protective of motor function decline in aging. Although playing a musical instrument may transfer to benefits in motor function, it is also possible that the genetic architecture of motor …

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GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging

Tara Lynn Henechowicz, Brooke Wolford, Rachana Nitin, Yasmina Mekki et autres

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45. GENOME-WIDE ASSOCIATION STUDY OF DEPRESSION-CAD COMORBID PHENOTYPE IS ENRICHED FOR INFLAMMATORY MECHANISMS AND IMMUNE PATHWAYS

Kritika Singh, Rachana Nitin, Freida Blostein, Daniel Levey et autres

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Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations

Srishti Nayak, Enikő Ladányi, Else Eising, Yasmina Mekki et autres

Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total N = …

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A contextual genomic perspective on physical activity and its relationship to health, well being and illness

Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Keyrun Adhikari et autres

Abstract Physical activity (PA) is one of the most fundamental traits in the animal kingdom, has pervasive health benefits, and is genetically influenced. Using data from the Million Veteran Program, we conducted genetic analyses of leisure, work and home-time PA. For leisure, …

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A contextual genomic perspective on physical activity and its relationship to health, well-being and illness

Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Keyrun Adhikari et autres

Abstract Physical activity (PA) is one of the most fundamental of all traits in the animal kingdom, has pervasive health benefits, and is genetically influenced. Using data from the Million Veteran Program (MVP), we conducted genetic analyses of leisure, work, and home-time …

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100. Understanding Genetic Profile Differences Between Schizophrenia and Bipolar Disorder

Minye Yao, Rachana Nitin, Lea K. Davis

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Polygenic Associations between Motor Behaviour, Neuromotor Traits, and Active Music Engagement in Four Cohorts

Tara Lynn Henechowicz, Peyton L. Coleman, Daniel E. Gustavson, Yasmina Mekki et autres

Phenotypic investigations have shown that actively engaging with music, i.e., playing a musical instrument or singing may be protective of motor decline in aging. For example, music training associated with enhanced sensorimotor skills accompanied by changes in brain structure and function. Although …

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Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

Jiayue-Clara Jiang, Kritika Singh, Rachana Nitin, Lea Karatheodoris Davis et autres

BACKGROUND: Though epidemiological studies show increased cardiovascular disease (CVD) risks among individuals with psychiatric disorders, findings on sex differences in comorbidity have been inconsistent. METHODS: This genetic epidemiology study examined the sex-specific association between the genetic risk of 3 psychiatric disorders (major …

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T4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS

Marco Galimberti, Priya Gupta, Joseph D. Deak, Cecilia Dao et autres

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