Paula Korn

In vivo real-time monitoring of tissue perfusion via L-lactate levels in interstitial fluid: an innovative and portable microfluidic device trial using a pig model

Xinne Zhao, Tom Alexander Schröder, Lars Heubner, Željko Janićijević et autres

BACKGROUND: The postoperative assessment of the tissue is a major challenge in reconstructive flap surgery. Lactate serves as a key indicator of metabolic dysfunction, providing essential insights into tissue oxygenation and perfusion, cellular stress, and identifying potential pathological conditions. Consequently, continuous monitoring …

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Proximal tibia for alveolar augmentation and augmentative rhinoplasty—a suitable option? A retrospective clinical study on donor and recipient site morbidity

Paula Korn, А В Мельников, Matthias Kühn, Samaneh Farahzadi et autres

BACKGROUND: Autologous bone grafts are essential in reconstructive oral and maxillofacial surgery, and depending on the donor site, they can be associated with specific harvesting morbidities. One of the most commonly applied bone grafts is the iliac crest bone graft, irrespective of …

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Evaluation of the Dimensional Accuracy of Robot-Guided Laser Osteotomy in Reconstruction with Patient-Specific Implants—An Accuracy Study of Digital High-Tech Procedures

Bilal Msallem, Lara Veronesi, Michel Beyer, Florian S. Halbeisen et autres

Background/Objective: With the rapid advancement in surgical technologies, new workflows for mandibular reconstruction are constantly being evaluated. Cutting guides are extensively employed for defining osteotomy planes but are prone to errors during fabrication and positioning. A virtually defined osteotomy plane and drilling …

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A cross-sectional study of the anatomy of the jaws of a central-European caucasian population using cone beam computer tomography as a prerequisite for designing pre-formed calcium phosphate cement scaffolds

Jan Matschke, Samaneh Farahzadi, Philipp Sembdner, Stefan Holtzhausen et autres

PURPOSE: This study aims to measure the cortical and cancellous bone thickness in the upper and lower jaws, serving as a data template for developing pre-defined calcium phosphate cement primary implant forms. These measurements are crucial for creating a biphasic scaffold. METHODS: …

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Gemischt radioopake und transluzente Raumforderung des Kiefers

Jonas Wüster, Paula Korn, Wolfgang Schmitt, Norbert Neckel et autres

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Comprehensive virtual orthognathic planning concept in surgery-first patients

Tobias Ebker, Paula Korn, Max Heiland, Axel Bumann

The surgery-first concept is becoming increasingly popular in orthognathic surgery since it offers major advantages such as a reduction of treatment duration and an increase in patient satisfaction by eliminating phases of presurgical orthodontic decompensation. Here, we present a novel interdisciplinary pathway …

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A systematic review on the effect of inorganic surface coatings in large animal models and meta‐analysis on tricalcium phosphate and hydroxyapatite on periimplant bone formation

Jeanne‐Marie Damerau, Susanne Bierbaum, Daniel B. Wiedemeier, Paula Korn et autres

The aim of the present systematic review was to analyse studies using inorganic implant coatings and, in a meta-analysis, the effect of specifically tricalcium phosphate (TCP) and hydroxyapatite (HA) implant surface coatings on bone formation according to the PRISMA criteria. Inclusion criteria …

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Toward Biofabrication of Resorbable Implants Consisting of a Calcium Phosphate Cement and Fibrin—A Characterization In Vitro and In Vivo

Tilman Ahlfeld, Anja Lode, Richard Frank Richter, Winnie Pradel et autres

Cleft alveolar bone defects can be treated potentially with tissue engineered bone grafts. Herein, we developed novel biphasic bone constructs consisting of two clinically certified materials, a calcium phosphate cement (CPC) and a fibrin gel that were biofabricated using 3D plotting. The …

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Stimulation of oral mucosal regeneration by low intensity pulsed ultrasound: an in vivo study in a porcine model

J. Chauvel-Picard, Paula Korn, Sara Corbin, Sophie Brosset et autres

PURPOSE: Many studies have shown the ability of low intensity pulsed ultrasound (LIPUS) to stimulate the bone, cartilage and tendon regeneration but only a few studied LIPUS interest in the regeneration of the oral mucosa. The purpose of this study is to …

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CD70 Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman

Renate Krüger, Emmanuel Martin, Jasmin Dmytrus, Cornelia Feiterna‐Sperling et autres

Most of the few patients with homozygous CD70 deficiency described to date suffered from EBV related malignancies in early childhood. We present a women with CD70 deficiency diagnosed in adulthood. She presented in childhood with recurrent airway infections due to encapsulated bacteria, …

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3D Printing of Bone Grafts for Cleft Alveolar Osteoplasty – In vivo Evaluation in a Preclinical Model

Paula Korn, Tilman Ahlfeld, Franziska Lahmeyer, David Kilian et autres

One of the most common hereditary craniofacial anomalies in humans are cleft lips and cleft alveolar bone with or without cleft palate. Current clinical practice, the augmentation of the persisting alveolar bone defect by using autologous bone grafts, has considerable disadvantages motivating …

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Bioprinting of mineralized constructs utilizing multichannel plotting of a self-setting calcium phosphate cement and a cell-laden bioink

Tilman Ahlfeld, Falko Doberenz, David Kilian, Corina Vater et autres

Due to their characteristic resemblance of the mineral component of bone, calcium phosphates are widely accepted as optimal bone substitute materials. Recent research focused on the development of pasty calcium phosphate cement (CPC) formulations, which can be fabricated into various shapes by …

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