David Kilian

Bio-design material as scaffold module proposed for surgical application in osteoarthritis: fabrication, characterization, biological evaluation of in vitro testing

Atsadaporn Thangprasert, Anne Bernhardt, Elke Gossla, David Kilian et autres

The treatment of osteochondral defects is a major topic of current research and has become more important in our aging society. The challenges in bone and cartilage repair arise from the structure and function of these different tissues. This study proposes a …

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Additive manufacturing of patient-specific, biphasic implants with zonal design for regeneration of osteochondral defects–critical evaluation of the work flow from clinical MRI data to implantation

Max von Witzleben, Suihong Liu, Philipp Sembdner, Stefan Holtzhausen et autres

Ideally, the combination of clinical imaging techniques with additive manufacturing processes enables the fabrication of patient-specific regenerative implants that precisely fit into the defect site, promoting native tissue restoration while gradually degrading. Osteochondral defects, affecting both cartilage and subchondral bone in joints …

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Novel Protein‐Rich Bioactive Bioink Stimulates Cellular Proliferation and Response in 3D Bioprinted Volumetric Constructs

Suihong Liu, David Kilian, Anne Bernhardt, Katharina Wirsig et autres

3D extrusion bioprinting, a promising and widely adopted technology in the emerging field of biofabrication, has gained considerable attention for its ability to fabricate hierarchically structured, native-mimicking tissue substitutes with precisely defined cell distributions. Despite notable advancements, the limited availability of suitably …

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One-step bioprinting of endothelialized, self-supporting arterial and venous networks

Betty Cai, David Kilian, Sadegh Ghorbani, Julien G. Roth et autres

Advances in biofabrication have enabled the generation of freeform perfusable networks mimicking vasculature. However, key challenges remain in the effective endothelialization of these complex, vascular-like networks, including cell uniformity, seeding efficiency, and the ability to pattern multiple cell types. To overcome these …

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Setting up a bioeconomy monitoring : sustainability – resources – products

Jörg Schweinle, Martin Banse, Johna Barrelet, Simone Brüning et autres

This Thünen Working Paper presents the results of the research project "Joint Project: Expansion of a systematic monitoring of the bioeconomy - consolidation phase." The project aimed to further develop the monitoring concept for the German bioeconomy and to update initial monitoring …

Author response for "One-step bioprinting of endothelialized, self-supporting arterial and venous networks"

Betty Cai, David Kilian, Sadegh Ghorbani, Julien G. Roth et autres

Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations

Jane E. Willoughby, Lang Dou, Sabyasachi Bhattacharya, Heather L. Jackson et autres

BACKGROUND: OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-mouse (m) OX40 and anti-human …

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Carbon screen‐printed electrodes modified with SiO2‐CuO‐glucose oxidase film for toxicity assessment using bacteria as indicator systems

Marko Kuznetsov, Oksana Tananaiko, Michael Gelinsky, Max von Witzleben et autres

Abstract A portable voltammetric sensor for toxicity assessment was developed based on a screen‐printed carbon electrode modified with SiO2‐CuO‐glucose oxidase (GOx) film. The method is based on the detection of the metabolic activity of E. coli towards glucose as an indicator systems …

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Hintergrundinformationen zum Status Quo der Land- und Forstwirtschaft in Deutschland und zukünftigen Biomassepotenzial für die Erarbeitung der NABIS

Klaus Hennenberg, Susanne Köppen, Martin Banse, Hannes Böttcher et autres

Der flächendeckende Ersatz fossiler Rohstoffe und Energieträger durch erneuerbare Alternativen ist nach Auffassung der Bundesregierung eine dringliche Aufgabe, die bis 2045 für die Erzeugung von Energie vollständig und für die stoffliche Nutzung von Biomasse in immer stärkerem Maße erfolgen soll. Dazu wird …

Diffusion‐Based 3D Bioprinting Strategies

Betty Cai, David Kilian, Daniel Ramos Mejia, Ricardo J. Rios et autres

3D bioprinting has enabled the fabrication of tissue-mimetic constructs with freeform designs that include living cells. In the development of new bioprinting techniques, the controlled use of diffusion has become an emerging strategy to tailor the properties and geometry of printed constructs. …

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Embedded 3D Bioprinting of Collagen Inks into Microgel Baths to Control Hydrogel Microstructure and Cell Spreading

Lucia G. Brunel, Fotis Christakopoulos, David Kilian, Betty Cai et autres

Microextrusion-based 3D bioprinting into support baths has emerged as a promising technique to pattern soft biomaterials into complex, macroscopic structures. It is hypothesized that interactions between inks and support baths, which are often composed of granular microgels, can be modulated to control …

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Gelation of Uniform Interfacial Diffusant in Embedded 3D Printing

Sungchul Shin, Lucia G. Brunel, Betty Cai, David Kilian et autres

While the human body has many different examples of perfusable structures with complex geometries, biofabrication methods to replicate this complexity are still lacking. Specifically, the fabrication of self-supporting, branched networks with multiple channel diameters is particularly challenging. Here, we present the Gelation …

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