Baixing Chen

Re-evaluating patient isolation policies for musculoskeletal infections in orthopaedic practice: a scoping review

Laura Bessems, Jolien Onsea, Baixing Chen, Marjan Wouthuyzen‐Bakker et autres

Introduction : Historically, isolating patients diagnosed with musculoskeletal infections (MSIs) from the general orthopaedic population has been regarded a fundamental aspect of effective infection control. However, this remains controversial. Evolving perspectives on infection prevention, resource constraints, and staffing shortages necessitate a reassessment …

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Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization

Baixing Chen, Bin Pu, Shaoshuo Li, Hang Dong

Osteomyelitis, characterized by bone inflammation and infection, poses a significant global health burden. This Mendelian randomization (MR) study investigates the causal relationship between polyunsaturated fatty acids (PUFAs) and osteomyelitis risk. By using GWAS data from 114,999 individuals, we explore specific PUFAs and …

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Evaluating the safety, pharmacokinetics and efficacy of phage therapy in treating fracture-related infections with multidrug-resistant Staphylococcus aureus: intravenous versus local application in sheep

Christian Peez, Baixing Chen, Leopold Henssler, Marco Chittò et autres

Background: , present significant clinical challenges due to the formation of biofilm on the implanted device, and reduced options for conventional antibiotic treatment. Bacteriophage (phage) therapy (PT) offers a targeted approach to managing such infections, however, evidence for pharmacokinetics and optimal route …

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Phage therapy: A primer for orthopaedic trauma surgeons

Baixing Chen, T. Fintan Moriarty, Willem‐Jan Metsemakers, Marco Chittò

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Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections

Baixing Chen, T. Fintan Moriarty, Hans Steenackers, Georges Vles et autres

Orthopedic-device-related infections (ODRIs) are challenging clinical complications that are often exacerbated by antibiotic resistance and biofilm formation. This review explores the efficacy of naturally occurring antimicrobials - including agents sourced from bacteria, fungi, viruses, animals, plants and minerals - against pathogens common …

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Isolation and Antibiofilm Activity of Bacteriophages against Cutibacterium acnes from Patients with Periprosthetic Joint Infection

Baixing Chen, Marco Chittò, Siyuan Tao, Jeroen Wagemans et autres

Background: Infections following shoulder surgery, particularly periprosthetic joint infection (PJI), are challenging to treat. Cutibacterium acnes is the causative pathogen in 39% to 76% of these cases. This study explores the efficacy of bacteriophage therapy as an alternative to conventional antibiotics for …

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Impact of SGLT2 inhibitors on lower limb complications: a mendelian randomization perspective

Baixing Chen, Mingling Huang, Bin Pu, Hang Dong

Background: While Sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective in managing diabetes and reducing cardiovascular risk, concerns about their association with lower limb complications, including, osteomyelitis, ulcers, and peripheral artery disease (PAD), persist. This study employs Mendelian Randomization (MR) to assess the …

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Optimization of bacteriophage therapy for difficult-to-treat musculoskeletal infections: a bench-to-bedside perspective

Laura Bessems, Baixing Chen, Saartje Uyttebroek, David Devolder et autres

Given the increasing threat of antimicrobial resistance, scientists are urgently seeking adjunct antimicrobial strategies, such as phage therapy (PT). However, despite promising results for the treatment of musculoskeletal infections in our center, crucial knowledge gaps remain. Therefore, a prospective observational study (PHAGEFORCE) …

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Combination of bacteriophages and vancomycin in a co-delivery hydrogel for localized treatment of fracture-related infections

Baixing Chen, Luis Ponce Benavente, Marco Chittò, Virginia Post et autres

Fracture-related infections (FRIs), particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated a hydrogel loaded with a cocktail of bacteriophages and vancomycin (1.2 mg/mL). The co-delivery hydrogel showed 99.72% reduction in MRSA biofilm in …

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Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization

Baixing Chen, Shaoshuo Li, Hang Dong

BACKGROUND: Previous research has extensively examined the role of interleukin 6 (IL-6) in sarcopenia. However, the presence of a causal relationship between IL-6, its receptor (IL-6R), and sarcopenia remains unclear. METHOD: In this study, we utilized summary-level data from genome-wide association studies …

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Investigating the relationship between muscle mass and nasal Methicillin-Resistant Staphylococcus aureus (MRSA) colonization: Analysis of the National Health and Nutrition Examination Survey (NHANES)

Baixing Chen, Shaoshuo Li, Shi Lin, Hang Dong

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization is associated with an increased risk of infection disease. Low muscle mass has been linked to higher levels of inflammatory markers and weakened immune response, which may impact the susceptibility to nasal MRSA colonization. The …

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SYNERGISTIC ACTION OF BACTERIOPHAGE AND VANCOMYCIN IN A CO-DELIVERY HYDROGEL FOR LOCALIZED TREATMENT OF FRACTURE-RELATED INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

Baixing Chen, Marco Chittò, Luis Ponce Benavente, Virginia Post et autres

Aim Bacteriophages are remerging as alternative and adjunctive therapy for fracture-related infection (FRI). However, current administration protocols involve prolonged retention of a percutaneous draining tube with potential risk of developing superinfection. In this study, we applied a cocktail of in vitro evolved …

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