Luis Ponce Benavente

Combination of bacteriophages and vancomycin in a co-delivery hydrogel for localized treatment of fracture-related infections

Baixing Chen, Luis Ponce Benavente, Marco Chittò, Virginia Post et autres

Fracture-related infections (FRIs), particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated a hydrogel loaded with a cocktail of bacteriophages and vancomycin (1.2 mg/mL). The co-delivery hydrogel showed 99.72% reduction in MRSA biofilm in …

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Targeted enhancement of bacteriophage activity against antibiotic-resistant Staphylococcus aureus biofilms through an evolutionary assay

Luis Ponce Benavente, Jeroen Wagemans, Dennis Hinkel, Alba Aguerri Lajusticia et autres

Staphylococcus aureus ´ biofilm-forming ability and rapid resistance development pose a significant challenge to successful treatment, particularly in postoperative complications, emphasizing the need for enhanced therapeutic strategies. Bacteriophage (phage) therapy has reemerged as a promising and safe option to combat multidrug-resistant bacteria. …

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SYNERGISTIC ACTION OF BACTERIOPHAGE AND VANCOMYCIN IN A CO-DELIVERY HYDROGEL FOR LOCALIZED TREATMENT OF FRACTURE-RELATED INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

Baixing Chen, Marco Chittò, Luis Ponce Benavente, Virginia Post et autres

Aim Bacteriophages are remerging as alternative and adjunctive therapy for fracture-related infection (FRI). However, current administration protocols involve prolonged retention of a percutaneous draining tube with potential risk of developing superinfection. In this study, we applied a cocktail of in vitro evolved …

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BACTERIOPHAGE THERAPY IN ORTHOPAEDIC AND CARDIOVASCULAR SURGERY: CLINICAL EXPERIENCE IN EIGHT PATIENTS WITH DIFFICULT-TO-TREAT INFECTIONS

Paula Morovic, Luis Ponce Benavente, Svetlana Karbysheva, Carsten Perka et autres

Aim Antibiotics have limited activity in the treatment of multidrug-resistant or chronic biofilm-associated infections, in particular when implants cannot be removed. Lytic bacteriophages can rapidly and selectively kill bacteria, and can be combined with antibiotics. However, clinical experience in patients with surgical …

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Alginate microbeads and hydrogels delivering meropenem and bacteriophages to treat Pseudomonas aeruginosa fracture-related infections

Baixing Chen, Luis Ponce Benavente, Marco Chittò, Jacek K. Wychowaniec et autres

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Bacteriophage Solid Propagation in Pseudomonas aeruginosa

Fabian Kunisch, Luis Ponce Benavente, Mercedes González Moreno

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Novel Bacteriophage Specific against Staphylococcus epidermidis and with Antibiofilm Activity

Rima Fanaei Pirlar, Jeroen Wagemans, Luis Ponce Benavente, Rob Lavigne et autres

Staphylococcus epidermidis has emerged as the most important pathogen in infections related to indwelling medical devices, and although these infections are not life-threatening, their frequency and the fact that they are extremely difficult to treat represent a serious burden on the public …

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