Albert T.A. Mairuhu

External validation of the SMART2 model for recurrent cardiovascular risk: performance in socioeconomic, ethnic and psychiatric subgroups

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Steven H J Hageman, T N Bonten et autres

BACKGROUND: Secondary prevention is critical for patients with established atherosclerotic cardiovascular diseases (ASCVD). The SMART2 model predicts recurrent ASCVD risk but does not account for psychiatric disorders, socioeconomic deprivation or ethnicity. We aimed to evaluate SMART2 model performance overall and in subgroups …

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Cost-effectiveness of follow-up algorithms for chronic thromboembolic pulmonary hypertension in pulmonary embolism survivors

Dieuwke Luijten, Wilbert B. van den Hout, Gudula J.A.M. Boon, Stefano Barco et autres

Introduction: Achieving an early diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) in pulmonary embolism (PE) survivors results in better quality of life and survival. Importantly, dedicated follow-up strategies to achieve an earlier CTEPH diagnosis involve costs that were not explicitly incorporated in …

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Optimisation of detecting chronic thromboembolic pulmonary hypertension in acute pulmonary embolism survivors: the InShape IV study

Dieuwke Luijten, Luca Valerio, Gudula J.A.M. Boon, Stefano Barco et autres

INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is often diagnosed late in acute pulmonary embolism survivors: more efficient testing to expedite diagnosis may considerably improve patient outcomes. The InShape II algorithm safely rules out CTEPH (failure rate 0.29%) while requiring echocardiography in only …

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Data Resource Profile: Extramural Leiden University Medical Center Academic Network (ELAN)

Janet M Kist, Hedwig M. M. Vos, Rimke Cathelijne Vos, Albert T.A. Mairuhu et autres

The Extramural Leiden University Medical Center Academic Network (ELAN) dynamic data infrastructure, based on routine healthcare data of general practitioners, hospitals and mental healthcare, linked to municipal and national data sources from Statistics Netherlands, was established with the aim to facilitate broad …

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Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial

Johanna Louise I. Burggraaf, Nienke van Rein, Remy H.H. Bemelmans, Jan Willem van den Berg et autres

INTRODUCTION: Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain whether patients with …

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Discharge from the emergency department and outpatient clinic in cancer patients with acute symptomatic and incidental pulmonary embolism: A multicenter retrospective cohort study

Noori A.M. Guman, Fleur H.J. Kaptein, Susan B. Lohle, Albert T.A. Mairuhu et autres

BACKGROUND: It is unclear how often cancer patients with acute pulmonary embolism (PE) are discharged from the emergency department (ED) or outpatient clinic and whether direct discharge is safe. We assessed treatment setting and early safety outcomes in cancer patients with acute …

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Treatment Patterns of Cancer-associated Thrombosis in the Netherlands: The Four Cities Study

Fleur H.J. Kaptein, Noori A.M. Guman, Susan B. Lohle, Frederikus Albertus Klok et autres

Abstract Background Current guidelines recommend either low-molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs) as first-line treatment in cancer-associated venous thromboembolism (VTE). Aim This study aimed to investigate treatment regimens for cancer-associated VTE over the past 5 years, explore predictors for …

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Cost-Effectiveness of Performing Reference Ultrasonography in Patients with Deep Vein Thrombosis

Cindy M.M. de Jong, Wilbert B. van den Hout, Christel E. van Dijk, Noor Heim et autres

BACKGROUND: The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) with compression ultrasonography (CUS) may be hindered by residual intravascular obstruction after previous DVT. A reference CUS, an additional ultrasound performed at anticoagulant discontinuation, may improve the diagnostic work-up of suspected recurrent …

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PB0447 Incidence of Chronic Thromboembolic Pulmonary Hypertension after Acute Pulmonary Embolism: An Update of the Literature

Dieuwke Luijten, Rosa Talerico, Stefano Barco, Suzanne C. Cannegieter et autres

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OC 71.2 Discharging Cancer Patients with Acute Pulmonary Embolism from the Emergency Department: A Multicenter Cohort Study

Natalio Guman, Fleur H.J. Kaptein, Susan B. Lohle, Albert T.A. Mairuhu et autres

Background: It is unclear how often cancer patients with acute symptomatic or incidental pulmonary embolism (PE) are discharged from the emergency department (ED), what the determinants of discharge are, and whether discharge from the ED is safe in this setting.Aims: To assess …

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Performance of the 4-Level Pulmonary Embolism Clinical Probability Score (4PEPS) in the diagnostic management of pulmonary embolism: An external validation study

Milou A.M. Stals, Ludo F.M. Beenen, Michiel Coppens, Laura M. Faber et autres

BACKGROUND: The recently published 4-level Pulmonary Embolism Clinical Probability Score (4PEPS) integrates different aspects from currently available diagnostic strategies to further reduce imaging testing in patients with clinically suspected pulmonary embolism (PE). AIM: To externally validate the performance of 4PEPS in an …

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Incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: an updated systematic review and meta-analysis

Dieuwke Luijten, Rosa Talerico, Stefano Barco, Suzanne C. Cannegieter et autres

Tweetable abstract The weighted pooled CTEPH incidence in PE survivors was 2.7%. RV dysfunction at the moment of the acute PE, unprovoked PE and/or recurrent VTE are associated with an increased CTEPH incidence. https://bit.ly/3Nd8GC0

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