Cost-effectiveness of follow-up algorithms for chronic thromboembolic pulmonary hypertension in pulmonary embolism survivors
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Le résumé fourni par la source
Introduction: Achieving an early diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) in pulmonary embolism (PE) survivors results in better quality of life and survival. Importantly, dedicated follow-up strategies to achieve an earlier CTEPH diagnosis involve costs that were not explicitly incorporated in the models assessing their cost-effectiveness. We performed an economic evaluation of 11 distinct PE follow-up algorithms to determine which should be preferred. Materials and methods: 11 different PE follow-up algorithms and one hypothetical scenario without a dedicated CTEPH follow-up algorithm were included in a Markov model. Diagnostic accuracy of consecutive tests was estimated from patient-level data of the InShape II study (n=424). The lifelong costs per CTEPH patient were compared and related to quality-adjusted life-years (QALYs) for each scenario. Results: Compared to not performing dedicated follow-up, the integrated follow-up algorithms are associated with an estimated increase of 0.89-1.2 QALYs against an incremental cost-effectiveness ratio (ICER) of EUR 25 700-46 300 per QALY per CTEPH patient. When comparing different algorithms with each other, the maximum differences were 0.27 QALYs and EUR 27 600. The most cost-effective algorithm was the InShape IV algorithm, with an ICER of EUR 26 700 per QALY compared to the next best algorithm. Conclusion: Subjecting all PE survivors to any of the currently established dedicated follow-up algorithms to detect CTEPH is cost-effective and preferred above not performing a dedicated follow-up, evaluated against the Dutch acceptability threshold of EUR 50 000 per QALY. The model can be used to identify the locally preferred algorithm from an economical point-of-view within local logistical possibilities.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cost-effectiveness of follow-up algorithms for chronic thromboembolic pulmonary hypertension in pulmonary embolism survivors
- Date Crossref
- 10/10/2024
- Éditeur
- European Respiratory Society (ERS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Leiden University Medical Center Department of Thrombosis and Hemostasis pays non établi dans la noticeOrganisme public
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Johannes Gutenberg University Mainz pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center of the Johannes Gutenberg University Mainz Department of Radiology pays non établi dans la noticeÉtablissement de santé
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University Hospital Zurich Clinic of Angiology pays non établi dans la noticeÉtablissement de santé
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Amsterdam University Medical Centers Department of Pulmonary Medicine pays non établi dans la noticeÉtablissement de santé
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KU Leuven pays non établi dans la noticeUniversité ou école supérieure
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Klinikum Würzburg Mitte pays non établi dans la noticeÉtablissement de santé
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Instituto de Salud Carlos III pays non établi dans la noticeOrganisme public
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Hospital Universitario Virgen del Rocío pays non établi dans la noticeÉtablissement de santé
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Democritus University of Thrace Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Haga Hospital pays non établi dans la noticeÉtablissement de santé
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Medical University of Warsaw Department of Internal Medicine and Cardiology pays non établi dans la noticeUniversité ou école supérieure
Department of Thrombosis and Hemostasis — Leiden University Medical Center, Johannes Gutenberg University Mainz et Department of Radiology — University Medical Center of the Johannes Gutenberg University Mainz, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.