Marie-Christine Lebrethon

Clinical Characterization of Atypical Diabetes: Insights from the GENEPEDIAB Study into the Spectrum Between Type 1 and Monogenic Diabetes

Antoine Harvengt, Gauthier Pirlot, Leyan Denizli, Zain Syed et autres

BACKGROUND: Type 1 diabetes (T1D) shares clinical characteristics with other forms of diabetes, particularly monogenic diabetes such as maturity-onset diabetes of the young (MODY). Differential diagnosis is complicated by the existence of intermediate phenotypes. We aimed to delineate the phenotypic continuum between …

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Monogenic etiologies among individuals with early‑onset obesity: findings from a real‑world Belgian cohort

Julie Harvengt, Muriel Hannon, Léonor Palmeira, Marie-Christine Lebrethon et autres

peer reviewed

[Plea for an early diagnosis of people at risk of developing symptomatic type 1 diabetes].

André Jacques Scheen, Madeleine Wéra, Jean‐Christophe Philips, Julie Fudvoye et autres

Type 1 diabetes (T1D) is an autoimmune chronic disease that leads to the destruction of pancreatic beta cells and thus requires lifelong insulin therapy. Constraints and adverse events associated to insulin therapy are well known as well as the risk of long-term …

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Monogenic etiologies in a cohort of early onset obesity: a real-world experience from Belgium

Julie Harvengt, Léonor Palmeira, Marie-Christine Lebrethon, Vinciane Dideberg et autres

Introduction: Obesity is a major global health issue with multifactorial etiologies. Among them, recent advances in the comprehension of eating and energy regulation showed that around 60 genes involved in the hypothalamic leptin/melanocortin pathway contribute to the development of rare monogenic or …

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Growth failure and chondrodysplasia following early hematopoietic stem cell transplantation for familial lymphohistiocytosis: a case report

Caroline Gernay, Marie-Christine Lebrethon, Julie Fudvoye, Parent Anne-Simone

Real-World Glycemic and Person-Reported Outcomes After Tandem Control-IQ Initiation in Children With Type 1 Diabetes

Jolien De Meulemeester, Laura Valgaerts, Guy Massa, Inge Gies et autres

CONTEXT: Real-world data add value to outcomes from randomized controlled trials on the use of hybrid closed-loop systems in the management of children and adolescents with type 1 diabetes. OBJECTIVE: This multicenter prospective observational cohort study assessed real-world changes in glycemic and …

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Population-based, first-tier genomic newborn screening in the maternity ward

François Boemer, Kristine Hovhannesyan, Flávia Balbo Piazzon, Frédéric Minner et autres

The rapid development of therapies for severe and rare genetic conditions underlines the need to incorporate first-tier genetic testing into newborn screening (NBS) programs. A workflow was developed to screen newborns for 165 treatable pediatric disorders by deep sequencing of regions of …

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The stage- and subgroup-specific impact of non-HLA polymorphisms on preclinical type 1 diabetes progression

Julie Vandewalle, Aster K. Desouter, Bart J.R. Van der Auwera, Kaven B Chapaza et autres

Besides variation within the HLA gene complex determining a major part of genetic susceptibility to Type 1 diabetes, genome-wide association studies have identified over 60 non-HLA loci also contributing to disease risk. While individual single nucleotide polymorphisms (SNPs) have limited predictive power, …

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A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms

Sophie Welsch, Antoine Harvengt, Paola Gallo, Manon Martin et autres

BACKGRUOUND: Recent diabetes subclassifications have improved the differentiation between patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus despite several overlapping features, yet without considering genetic forms of diabetes. We sought to facilitate the identification of monogenic diabetes by …

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Associations between endocrine disruptor contamination and thyroid hormone homeostasis in Belgian type 1 diabetic children

Patrice Dufour, Catherine Pirard, Marie-Christine Lebrethon, Corinne Charlier

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Efficacy and safety of a 4-year combination therapy of growth hormone and gonadotropin-releasing hormone analogue in pubertal girls with short predicted adult height

Hilde Dotremont, Annick France, Claudine Heinrichs, Sylvie Tenoutasse et autres

Objectives: To improve adult height in pubertal girls with a poor height prediction, treatment with growth hormone (GH) can be used in combination with a gonadotropin releasing hormone agonist (GnRHa), to delay closure of the growth plates. However, there are few studies …

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OR03-5 Identification of Four New Glucotypes during the First Year after Type 1 Diabetes Onset Using Continuous Glucose Monitoring Metrics

Antoine Delfosse, Marieke den Brinker, Laurent Gatto, Inge Gies et autres

Abstract Current markers of β-cell function poorly reflect glucose homeostasis after diabetes onset, mainly because of the lack of integration of parameters of insulin sensitivity and β-cell responsiveness to glucose. Recently, the widespread use of continuous glucose monitoring (CGM) helped stratify glucose …