Mandip S. Singh

Innovative Nasal Drug Delivery Systems for Effective Brain Targeting and Blood-Brain Barrier Overcoming

Mandip S. Singh, Umar Farooq, Sajad Ahmed Gani

Central nervous system (CNS) disorders remain among the most challenging conditions to treat due to the restrictive nature of the blood-brain barrier (BBB), which significantly limits the delivery of therapeutic agents to the brain. Traditional systemic drug delivery methods often result in …

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Development and adhesion evaluation of transdermal rotigotine patches utilizing 3D-printed skin-mimicking substrate, solid-state NMR, and ATR-FTIR techniques

Arvind Bagde, Keb M. Mosley-Kellum, Sungsool Wi, Nisarg Modi et autres

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Antitumor Potential of Guttiferone E Combined With Carboplatin Against Osimertinib-resistant H1975 Lung Cancer Through Apoptosis

Aakash Nathani, Islauddin Khan, Matheus Hikaru Tanimoto, Jennyfer Andrea Aldana Mejía et autres

Background/Aim: Low selectivity and high frequency of side-effects are the major problems of currently used chemotherapeutics. Among natural compounds, the polyprenylated acylphloroglucinol, guttiferone E, isolated from Brazilian red propolis, has attracted attention due to its marked anticancer properties and was evaluated here …

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Unlocking the Potential of Camel Milk-Derived Exosomes as Novel Delivery Systems: Enhanced Bioavailability of ARV-825 PROTAC for Cancer Therapy

Aakash Nathani, Mounika Aare, Li Jun Sun, Arvind Bagde et autres

This study investigates the use of camel milk-derived exosomes (CMEs) as carriers for ARV-825, an anticancer agent targeting bromodomain-containing protein 4 (BRD4), in oral chemotherapy. CMEs were isolated and characterized, and ARV-825-loaded CME formulations were prepared and evaluated through various in vitro …

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Development of novel skin-mimetic substrate with 3D printing to assess the adhesion properties of transdermal patches

Arvind Bagde, Keb M. Mosley-Kellum, Oluwaseyi Salau, Satyanarayan R. S. Dev et autres

Transdermal system (TDS) patches, a long-standing product in the market, still grapple with issues of secure skin adherence, efficacy, and safety. Hence, there is a pressing need to study factors affecting TDS patch adhesion on skin-mimetic substrates to enhance reliability and reduce …

Correction: Development of 3D DLP Printed Sustained Release Ibuprofen Tablets and Their Pharmacokinetic Evaluation in Rats

Keb M. Mosley-Kellum, Arvind Bagde, Shawn D. Spencer, Satyanarayan R. S. Dev et autres

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Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis

Islauddin Khan, Sukhmandeep Kaur, Arun K. Rishi, Breana Boire et autres

BACKGROUND: In this study, we investigated in detail the role of cannabidiol (CBD), beta-caryophyllene (BC), or their combinations in diabetic peripheral neuropathy (DN). The key factors that contribute to DN include mitochondrial dysfunction, inflammation, and oxidative stress. METHODS: Briefly, streptozotocin (STZ) (55 …

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Enhanced oral bioavailability and in vitro evaluation of cannabidiol camel milk-derived exosome formulation in resistant MDA-MB-231 and MDA-MB-468 breast cancer cells

Mounika Aare, Arvind Bagde, Aakash Nathani, Arun K. Rishi et autres

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Development of Novel Skin Mimetic Substrate to Assess the Adhesion Properties of Transdermal Patches

Arvind Bagde, Keb M. Mosley-Kellum, Oluwaseyi Salau, Satyanarayan R. S. Dev et autres

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3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats

Arvind Bagde, Keb M. Mosley-Kellum, Shawn D. Spencer, Mandip S. Singh

OBJECTIVE: The objective of the present study was to enhance the bioavailability of cannabidiol (CBD) using 3D Digital Light Processing (DLP)-printed microneedle (MN) transdermal drug delivery system. METHODS: CBD MN patch was fabricated and optimized using 3D DLP printing using CBD (8% …

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Abstract 4566: Synergistic anticancer activity of cannabinoids and beta caryophyllene in xenograft mouse model of triple negative breast cancer

Mounika Aare, Islauddin Khan, Aakash Nathani, Breana Boirie et autres

Abstract Combination therapy, a treatment modality that studies the effect of two or more drugs is the most common strategy used to overcome drug resistance in cancer. Cannabinoids have been proven to be potential anticancer agents. Terpenes have also been demonstrated to …

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Abstract 7578: BRD4 protein degradation for p53 mutant diffuse intrinsic pontine glioma (DIPG) via various delivery approaches for ARV-825 by using camel milk exosomes

Aakash Nathani, Mounika Aare, Li Jun Sun, Yan Li et autres

Abstract DIPGs (diffuse intrinsic pontine gliomas) are a particularly aggressive and malignant type of pediatric brain tumor. Given the tumor's location, surgery has a restricted role, and it is insensitive to most chemotherapies. Although fractionated radiation is the standard of therapy for …

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