Li Sun

A Rapid Poly(ethylene glycol)-Assisted Magnetic Isolation Approach for High-Throughput Extracellular Vesicle Isolation and Subsequent Biomarker Analysis

Li Sun, Leanne Duke, Cynthia Vied, Grace Hammel et autres

Extracellular vesicles (EVs) are crucial mediators of intercellular communication and have the potential to serve as biomarkers for disease diagnosis and therapeutic monitoring. However, most EV isolation methods often require large sample volumes and specialized instruments or involve trade-offs between purity, yield, …

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Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles

Dirk P. Dittmer, Leanne C. Duke, Robert J. Tomko, Li Sun et autres

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Immuno‐Regulation of Brain Region‐Specific Organoids Containing Isogenic Microglia‐Like Cells

Chang Liu, Justice Ene, Wenyan Lü, Li Sun et autres

Most brain organoids derived from human induced pluripotent stem cells (iPSCs) lack microglia and thus immune function. Microglia-like cells (MGCs) can be differentiated from iPSCs, while the characteristics of isogenic MGC-containing brain organoids in modeling neurodegeneration and cell-cell communications have not been …

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Neurofunctional MOF nanoparticles integrated with extracellular matrix hydrogel for neuro-Vascularized bone regeneration

Ning Sheng, Runze Yang, Jie Wang, Wenting Wu et autres

The neural and vascular systems are the basic elements of bone. Neurovascular networks are widely distributed throughout the periosteum, cortical bone, and cancellous bone, which is highly significant for bone regeneration and remodeling. Reconstruction of the neurovascular network has been proposed as …

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EXTH-145. Chimeric Antigen Receptor-Engineered Extracellular Vesicles from Human Stem Cell-Derived Neutrophils for Glioblastoma Therapy

Loizos Michaelides, Colin Esmonde, Li Sun, Yun Chang et autres

Abstract Glioblastoma (GBM) is the most common malignant tumor of the CNS, accounting for 80% of brain tumors. Recent advances in gene editing and immunology have led to the development of chimeric antigen receptors (CARs), including CARs incorporating chlorotoxin (CLTX) receptor domains …

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Engineered Nanobody-Bearing Extracellular Vesicles Enable Precision Trop2 Knockdown in Resistant Breast Cancer

Jassy Mary S. Lazarte, Mounika Aare, Sandeep Chary Padakanti, Arvind Bagde et autres

Background/Objectives: Trophoblast cell surface antigen 2 (Trop2), a transmembrane glycoprotein overexpressed in a broad spectrum of epithelial malignancies but minimally expressed in normal tissues, has emerged as a clinically relevant prognostic biomarker and therapeutic target, particularly in breast cancer. This study aims …

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Advancing biological understanding of cellular senescence with computational multiomics

Sheng Li, Paula A. Agudelo Garcia, Constantin Aliferis, Michael J. Becich et autres

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124 I‐labelled BMSC‐Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP‐Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis

Yujie Pan, Xianteng Yang, Zhirui Zeng, Futao Liu et autres

ABSTRACT Metastasis constitutes the principal factor leading to the unfavourable prognosis of osteosarcoma patients. Hypoxia, as the inherent microenvironment of osteosarcoma, can upregulate HIF‐1α via multiple pathways, thereby facilitating osteosarcoma proliferation and metastasis. Our previous research indicated that the inwardly rectifying potassium …

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Cargo Analysis and MRI‐Based Therapeutic Assessment of Iron Oxide Labelled Extracellular Vesicles of Hypoxia Human Stem Cells in Ischemic Stroke

Shannon Helsper, Li Sun, Richard Jeske, Chang Liu et autres

ABSTRACT Human mesenchymal stem cells (hMSCs) have been under investigation in preclinical and clinical settings for treating neurological disorders in recent years. Predominantly due to paracrine effects in vivo, hMSC‐secreted extracellular vesicles (EVs) are at the forefront of these investigations. In this …

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A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III clinical trial to assess the efficacy and safety of Yuping Tongqiao tablets in the treatment of persistent allergic rhinitis

Junge Wang, Jianjun Chen, Chengcheng Deng, Yaowu Dong et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Yuping Tongqiao Tablets is a classic traditional Chinese medicine (TCM) formula commonly employed in China for managing various ailments, especially allergic conditions. Clinical reports indicate its potential as an effective treatment for persistent allergic rhinitis. Nevertheless, there remains a dearth …

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Cannabidiol-Loaded Retinal Organoid-Derived Extracellular Vesicles Protect Oxidatively Stressed ARPE-19 Cells

Peggy Arthur, Sangeetha Kandoi, Anil Kumar Kalvala, Breana Boirie et autres

Background/Objectives: Age-related macular degeneration (AMD) is the third leading cause of irreversible blindness in elderly individuals aged over 50 years old. Oxidative stress plays a crucial role in the etiopathogenesis of multifactorial AMD disease. The phospholipid bilayer EVs derived from the culture-conditioned …

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Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours

Andrew T. Luskin, Li Li, Xiaonan Fu, Madison M. Martin et autres

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