Arnold P.G. Hoeks

No accelerated arterial aging in relatively young women after preeclampsia as compared to normotensive pregnancy

Emma B N J Janssen, Mieke C.E. Hooijschuur, Veronica A. Lopes van Balen, Erjona Morina-Shijaku et autres

Introduction Preeclampsia, an endothelial disorder of pregnancy, predisposes to remote cardiovascular diseases (CVD). Whether there is an accelerated effect of aging on endothelial decline in former preeclamptic women is unknown. We investigated if the arterial aging regarding endothelial-dependent and -independent vascular function …

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Ultrasonic Perfluorohexane‐Loaded Monocyte Imaging: Toward a Minimally Invasive Technique for Selective Detection of Liver Inflammation in Fatty Liver Disease

Koen D. Reesink, Tim Hendrikx, Patrick J. van Gorp, Arnold P.G. Hoeks et autres

Objectives To investigate the utility of ultrasonic (US) perfluorohexane (PFH)‐loaded monocyte imaging for detection of liver inflammation in fatty liver disease. Methods C57Bl6 mice were injected intraperitoneally with tumor necrosis factor α and assessed by US PFH‐loaded monocyte imaging 3 hours later. …

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Heart rate lowering treatment leads to a reduction in vulnerable plaque features in atherosclerotic rabbits

Raf H.M. van Hoof, Evelien Hermeling, Judith C. Sluimer, Julie Salzmann et autres

OBJECTIVE: To investigate the effect of a heart rate (HR) lowering agent (Ivabradine) on features of atherosclerotic plaque vulnerability with magnetic resonance imaging (MRI), ultrasound imaging, and histology. APPROACH AND RESULTS: Atherosclerosis was induced in the abdominal aorta of 19 rabbits. Nine …

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High Spatial Inhomogeneity in the Intima-Media Thickness of the Common Carotid Artery is Associated with a Larger Degree of Stenosis in the Internal Carotid Artery: The PARISK Study

Jeire Steinbuch, Anouk van Dijk, Floris H.B.M. Schreuder, Martine T.B. Truijman et autres

Abstract Purpose Inhomogeneity of arterial wall thickness may be indicative of distal plaques. This study investigates the intra-subject association between relative spatial intima-media thickness (IMT) inhomogeneity of the common carotid artery (CCA) and the degree of stenosis of plaques in the internal …

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Standard B-Mode Ultrasound Measures Local Carotid Artery Characteristics as Reliably as Radiofrequency Phase Tracking in Symptomatic Carotid Artery Patients

Jeire Steinbuch, Arnold P.G. Hoeks, Evelien Hermeling, Martine T.B. Truijman et autres

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Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women

Marjo H.J. Knapen, Lavienja A. J. L. M. Braam, Nadja E.A. Drummen, Otto Bekers et autres

Observational data suggest a link between menaquinone (MK, vitamin K2) intake and cardiovascular (CV) health. However, MK intervention trials with vascular endpoints are lacking. We investigated long-term effects of MK-7 (180 µg MenaQ7/day) supplementation on arterial stiffness in a double-blind, placebo-controlled trial. …

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A Control Systems Approach to Quantify Wall Shear Stress Normalization by Flow-Mediated Dilation in the Brachial Artery

Frank C.G. van Bussel, Bas C. T. van Bussel, Arnold P.G. Hoeks, Jos Op ’t Roodt et autres

Flow-mediated dilation is aimed at normalization of local wall shear stress under varying blood flow conditions. Blood flow velocity and vessel diameter are continuous and opposing influences that modulate wall shear stress. We derived an index FMDv to quantify wall shear stress …

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Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study

Liselotte M. Kornmann, Alma Zernecke, Daniëlle M.J. Curfs, Ben J. Janssen et autres

BACKGROUND: Macrophages may concentrate ultrasound contrast agents and exhibit selective adhesion to activated endothelium. The present study investigates in mice the potential of perfluorohexane (PFH) loaded macrophages to act as ultrasound contrast agent with high reflectivity and specifically targeted at (atherosclerotic) vascular …

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challengeventriculoarterial responses to orthostatic Carotid artery pulse wave time characteristics to

Arnold P.G. Hoeks, Koen D. Reesink, Evelien Hermeling, M. Christianne Hoeberigs et autres

Arterial stiffness and hypertension in a large population of untreated individuals

Germaine C. Verwoert, Oscar H. Franco, Arnold P.G. Hoeks, Robert S. Reneman et autres

OBJECTIVE: We studied whether arterial stiffness measured as aortic pulse wave velocity (aPWV) and carotid distensibility was associated with different subtypes of hypertension in a large population of untreated middle-aged and elderly men and women. METHODS: The study was conducted within the …

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A novel approach to assess hemorrhagic shock severity using the arterially determined left ventricular isovolumic contraction period

Marc J. van Houwelingen, Daphne Merkus, Jan Hofland, Jan Bakker et autres

Recently, the ventilatory variation in pre-ejection period (ΔPEP) was found to be useful in the prediction of fluid-responsiveness of patients in shock. In the present study we investigated the behavior of the ventilation-induced variations in the systolic timing intervals in response to …

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Assessment of systolic and diastolic arterial stiffness

Evelien Hermeling, Arnold P.G. Hoeks, Robert S. Reneman, Patrick Segers et autres

Hermeling, Evelien; Hoeks, Arnold P.G.; Reneman, Robert S.; Segers, Patrick; Reesink, Koen D. Author Information

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