No accelerated arterial aging in relatively young women after preeclampsia as compared to normotensive pregnancy
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Le résumé fourni par la source
Introduction Preeclampsia, an endothelial disorder of pregnancy, predisposes to remote cardiovascular diseases (CVD). Whether there is an accelerated effect of aging on endothelial decline in former preeclamptic women is unknown. We investigated if the arterial aging regarding endothelial-dependent and -independent vascular function is more pronounced in women with a history of preeclampsia as compared to women with a history of solely normotensive gestation(s). Methods Data was used from the Queen of Hearts study (ClinicalTrials.gov Identifier NCT02347540); a large cross-sectional study on early detection of cardiovascular disease among young women (≥18 years) with a history of preeclampsia and a control group of low-risk healthy women with a history of uncomplicated pregnancies. Brachial artery flow-mediated dilation (FMD; absolute, relative and allometric) and sublingually administered nitroglycerine-mediated dilation (NGMD; absolute and relative) were measured using ultrasound. Cross-sectional associations of age with FMD and NGMD were investigated by linear regression. Models were adjusted for body mass index, smoking, antihypertensive drug use, mean arterial pressure, fasting glucose, menopausal state, family history of CVD and stress stimulus during measurement. Effect modification by preeclampsia was investigated by including an interaction term between preeclampsia and age in regression models. Results Of the 1,217 included women (age range 22–62 years), 66.0% had a history of preeclampsia and 34.0% of normotensive pregnancy. Advancing age was associated with a decrease in relative FMD and NGMD (unadjusted regression coefficient: FMD: −0.48%/10 years (95% CI:−0.65 to −0.30%/10 years), NGMD: −1.13%/10 years (−1.49 to −0.77%/10 years)) and increase in brachial artery diameter [regression coefficient = 0.16 mm/10 years (95% CI 0.13 to 0.19 mm/10 years)]. Similar results were found when evaluating FMD and NGMD as absolute increase or allometrically, and after confounder adjustments. These age-related change were comparable in former preeclamptic women and controls (p-values interaction ≥0.372). Preeclampsia itself was independently associated with consistently smaller brachial artery diameter, but not with FMD and NGMD. Conclusion In young- to middle-aged women, vascular aging in terms of FMD and NGMD was not accelerated in women after preeclampsia compared to normotensive pregnancies, even though former preeclamptic women consistently have smaller brachial arteries.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- No accelerated arterial aging in relatively young women after preeclampsia as compared to normotensive pregnancy
- Date Crossref
- 28/07/2022
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Maastricht University Medical Centre Cardiovascular Research Institute Maastricht (CARIM) pays non établi dans la noticeOrganisme public
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Maastricht University pays non établi dans la noticeUniversité ou école supérieure
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Zuyderland Medisch Centrum pays non établi dans la noticeÉtablissement de santé
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Care and Public Health Research Institute pays non établi dans la noticeStructure de recherche
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center pays non établi dans la noticeOrganisme public
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Department of Biomedical Engineering pays non établi dans la noticeInstitution
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Department of Clinical Epidemiology and Medical Technology Assessment pays non établi dans la noticeÉtablissement de santé
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Department of Cardiology pays non établi dans la noticeInstitution
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Department of Intensive Care Medicine pays non établi dans la noticeInstitution
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Radboud University Medical Centre Department of Obstetrics and Gynaecology pays non établi dans la noticeUniversité ou école supérieure
Cardiovascular Research Institute Maastricht (CARIM) — Maastricht University Medical Centre, Maastricht University et Zuyderland Medisch Centrum, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.