Arterial stiffness and hypertension in a large population of untreated individuals
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Le résumé fourni par la source
OBJECTIVE: We studied whether arterial stiffness measured as aortic pulse wave velocity (aPWV) and carotid distensibility was associated with different subtypes of hypertension in a large population of untreated middle-aged and elderly men and women. METHODS: The study was conducted within the framework of the population-based Rotterdam Study. We included 4088 individuals with information on aPWV, with 3554 individuals with carotid distensibility measurements without use of antihypertensive medication. Isolated systolic hypertension (ISH) was defined as SBP at least 140 mmHg and DBP less than 90 mmHg. Combined systolic and diastolic hypertension (Sys/Dia hypertension) was defined as SBP at least 140 mmHg and DBP at least 90 mmHg. Analysis of covariance was used to compare means of arterial stiffness for the different subtypes of hypertension. Multinomial logistic regression analysis was performed to investigate the association of arterial stiffness and the subtypes of hypertension in models adjusted for age, sex, mean arterial pressure, heart rate and cardiovascular risk factors. RESULTS: The mean age of the individuals was 68 years: 45.3% were men, 1597 individuals had ISH and 441 individuals had Sys/Dia hypertension. aPWV was higher (13.2 vs. 12.9 m/s; P = 0.008) in individuals with ISH compared to those with Sys/Dia hypertension. Multivariate odds ratios and corresponding 95% confidence interval of aPWV for ISH were 1.53 (1.38-1.71) and 1.28 (1.09-1.53) for Sys/Dia hypertension. Corresponding odds ratios associated with carotid distensibility were 0.84 (0.75-0.94) and 0.66 (0.54-0.81), respectively. Age significantly modified the association of aPWV with subtypes of hypertension (P < 0.001). CONCLUSION: In a large untreated population, we found significant associations of both aPWV and carotid distensibility with ISH and Sys/Dia hypertension. individuals with ISH had higher values of aortic stiffness when compared to individuals with Sys/Dia hypertension, a difference that was most pronounced at older age. The results suggest that aortic stiffness contributes to ISH in older individuals without treatment for hypertension.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Arterial stiffness and hypertension in a large population of untreated individuals
- Date Crossref
- 01/08/2014
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Maastricht University Medical Centre Erasmus Medical Center pays non établi dans la noticeOrganisme public
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Erasmus MC pays non établi dans la noticeÉtablissement de santé
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Maastricht University pays non établi dans la noticeUniversité ou école supérieure
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Erasmus University Rotterdam pays non établi dans la noticeUniversité ou école supérieure
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Department of Epidemiology pays non établi dans la noticeInstitution
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Erasmus Medical Center Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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e-mail: [email protected] pays non établi dans la noticeInstitution
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fax: +31 107034768 pays non établi dans la noticeInstitution
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Department of Biomedical Engineering pays non établi dans la noticeInstitution
Erasmus Medical Center — Maastricht University Medical Centre, Erasmus MC et Maastricht University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.