Kuo Dang

Identification of Novel AChE-Targeting Neuroprotective Peptides from Pacific Oyster (Crassostrea gigas): An Integrated Pipeline of Peptidomics, Molecular Dynamics, and Cellular Validation

Shikun Suo, Kuo Dang, Yingying Zhang, Yao-Yao Zhang et autres

Although the Pacific oyster (Crassostrea gigas) is a premium marine protein source, its neuroprotective peptidome remains largely uncharacterized. This study established an integrated in silico and in vitro pipeline to discover acetylcholinesterase (AChE)-targeting peptides with cellular AChE-regulating and neuroprotective peptides from simulated …

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Molecular mechanisms of oyster-derived umami peptides: Docking, dynamics simulation, and MM-PBSA analysis based on optimal enzymolysis

Shikun Suo, Kuo Dang, Yanli Wang, Daodong Pan et autres

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Synergistic umami–enhancing mechanism of novel umami peptides from Mactra Veneriformis and Ruditapes Philippinarum clams with four basic umami substances by multi–ligand molecular docking, molecular dynamics simulations and stably transfected umami receptor cells

Yanli Wang, Kuo Dang, Ting Zhang, Shikun Suo et autres

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Chicken sternum cartilage protein-chelated calcium: enhance bone density in vivo and in vitro, with insights into chelation mechanism

Shikun Suo, Yanli Wang, Lihui Du, Maolin Tu et autres

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Discovery of ActRIIB antagonistic peptides from in vitro-digested chicken breast meat via an integrated Peptidomics and molecular docking approach

Fei Zhao, Junwei Yan, Zhiguo Liu, Daodong Pan et autres

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An in vivo study of the antihypertensive effects of the umami peptide AHSVRFY from Parma ham and its intestinal digestion

Qian Ding, Tianyu Wang, Kuo Dang, Yanli Wang et autres

molecular docking and dynamics simulations. This work shows that AHSVRFY's antihypertensive effect originates from GI-derived bioactive peptides, establishing a "digestion-activation-delivery" framework for the development of multifunctional food ingredients.

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Enhancing cognitive function with biopeptides from porcine brain hydrolysates via key targets: Keap1, p38α, AChE, and BACE1

Kuo Dang, Qianqian Zheng, Tianqiong Zhou, Yanli Wang et autres

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Effect of chicken sternum cartilage on bone mineral density and its mechanism

Shikun Suo, Jie Wang, Kuo Dang, Hira Nawazish et autres

Abstract BACKGROUND Osteoporosis is defined by decreased bone mineral density (BMD) – a core factor for bone strength and fracture risk – with progression often exacerbated by chronic inflammation. However, the role of chicken sternum cartilage (CSC) in improving bone health and …

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Design and experimental verification of novel angiotensin‐converting enzyme and dipeptidyl peptidase IV inhibitory peptides from Ziziphus jujuba peptide KALVAP

Huan Wen, Jing Lan, Kuo Dang, Yanli Wang et autres

Abstract BACKGROUND KALVAP is an angiotensin‐converting enzyme inhibitor derived from Ziziphus jujuba , but shows poor dipeptidyl peptidase (DPP)‐IV inhibitory activity. To remedy this shortcoming, KALVAP was modified according to the distinctive features of DPP‐IV inhibitory peptides, yielding nine novel peptides. The …

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Elucidating the umami mechanism of novel oyster-derived peptides: an approach combining in silico enzymolysis and molecular dynamics simulation

Shikun Suo, Kuo Dang, Yanli Wang, Daodong Pan et autres

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Quantitative Peptidomic profiling of caprine and bovine Milk after simulated gastrointestinal digestion: A multidimensional analytical strategy integrating UHPLC-Q-TOF-MS and QqQ-MS

Fei Zhao, Jing Lan, Kuo Dang, Yanli Wang et autres

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Unraveling novel umami peptides in Hericium erinaceus and its umami mechanism by ion exchange chromatography, peptidomics and molecular dynamics simulations

Tao He, Kuo Dang, Yanli Wang, Daodong Pan et autres

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