Yingying Zhang

Identification of Novel AChE-Targeting Neuroprotective Peptides from Pacific Oyster (Crassostrea gigas): An Integrated Pipeline of Peptidomics, Molecular Dynamics, and Cellular Validation

Shikun Suo, Kuo Dang, Yingying Zhang, Yao-Yao Zhang et autres

Although the Pacific oyster (Crassostrea gigas) is a premium marine protein source, its neuroprotective peptidome remains largely uncharacterized. This study established an integrated in silico and in vitro pipeline to discover acetylcholinesterase (AChE)-targeting peptides with cellular AChE-regulating and neuroprotective peptides from simulated …

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Urinary long non-coding RNA GAS5 as a noninvasive diagnostic biomarker for renal fibrosis

Ying Yu, Yangyang Niu, Yingying Zhang, Yu Chen

BACKGROUND: Renal fibrosis, the terminal pathological pathway of chronic kidney disease (CKD), lacks reliable noninvasive biomarkers for clinical assessment. Current diagnostic reliance on renal biopsy-despite its gold-standard status-poses risks of bleeding and sampling errors, necessitating alternatives. Long non-coding RNA growth arrest-specific 5 …

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MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction

Huijun Zhou, Han Gong, Xiaohui Zeng, Chong Zeng et autres

One‑carbon metabolism plays an important role in cancer progression. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme in one‑carbon metabolism, is dysregulated in several cancer types. However, the precise role and mechanisms of MTHFD2 in esophageal squamous cell carcinoma (ESCC) remain unclear. The …

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Potential Distribution and Response of Camphora longepaniculata Gamble (Lauraceae) to Climate Change in China

Yanzhao Zhu, Yidi Liu, Minghui Zhu, Yujie Yan et autres

Camphora longepaniculata is an endangered evergreen tree listed as National Class II Protected Tree Species in China, highly valued for its medicinal and economic importance. Currently, research on this species has primarily focused on its pharmaceutical properties, while its potential distribution and …

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Investigation of the Molecular Mechanism of Asthma in Meishan Pigs Using Multi-Omics Analysis

Weilong Tu, Hongyang Wang, Yingying Zhang, Ji Huang et autres

Asthma has been extensively studied in humans and animals, but the molecular mechanisms underlying asthma in Meishan pigs, a breed with distinct genetic and physiological characteristics, remain elusive. Understanding these mechanisms could provide insights into veterinary medicine and human asthma research. We …

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Peptide-Based PROTAC Degrader of CDA1 Suppresses Diabetic Kidney Disease

Jiao Wu, Shasha Cheng, Yingying Zhang, Xiaoyan Li et autres

Background: Diabetic kidney disease (DKD) is a leading cause of mortality and morbidity in diabetes, representing a predominant cause of renal failure worldwide. The expression of cell division autoantigen 1 (CDA1) is elevated in the kidneys of diabetic animal models, which can …

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Autophagy Attenuation-Induced LSD1 Enrichment Promotes Renal Tubular Cell Senescence and Kidney Aging

Yingying Zhang, Xiaoyan Li, Chen Yu, Xiaogang Li

Background: The process of population aging will inevitably lead to an increase in age-related comorbidities, including CKD. Alterations of epigenetic modifications are associated with aging at various levels, making them promising targets for interventions against age-related CKD. Lysine-specific demethylase 1 (LSD1) as …

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Glucagon-Like Peptide 1 Receptor Agonist (GLP-1 RA) Delays Cyst Growth in ADPKD

Jiao Wu, Shasha Cheng, Yingying Zhang, Xiaoyan Li et autres

Background: ADPKD is the most frequent genetic cause of chronic kidney disease (CKD), accounting for 6-10 % of patients on dialysis in the United States. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of drugs utilized to treat type 2 diabetes mellitus …

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Rising above: exploring the therapeutic potential of natural product-based compounds in human cancer treatment

Shi-Zeng Lei, Wenjing Xu, Yu-Xin Lai, Yingying Zhang et autres

PhoP/PhoQ Two-Component System Contributes to Intestinal Inflammation Induced by Cronobacter sakazakii in Neonatal Mice

Yan Ma, Yingying Zhang, Yuting Wang, Zhu Qiao et autres

Cronobacter sakazakii (C. sakazakii) is a foodborne pathogen capable of causing severe infections in newborns. The PhoP/PhoQ two-component system exerts a significant influence on bacterial virulence. This study aimed to investigate the impact of the PhoP/PhoQ system on intestinal inflammation in neonatal …

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Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes

Hongyan Wang, Jian-Yang Chen, Yanan Li, Xianghui Zhang et autres

Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function and susceptibility to disease. Adaptive immunity is a shared trait of the common ancestor of cartilaginous and bony fishes. However, evolutionary features of lymphocytes in these two …

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Comprehensive analysis of single-nucleotide variants and alternative polyadenylation between inbred and outbred pigs

Yu Han, Weilong Tu, Yingying Zhang, Ji Wei Huang et autres

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