Kansuke Kido

Transient Left Ventricular Dysfunction in Loeys-Dietz Syndrome With Loss-of-Function TGFBR1 Variants

Yuna Hirota, Shuichiro Higo, Tomoka Tabata, Yuki Kuramoto et autres

BACKGROUND: Loeys-Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder characterized by vascular and valvular diseases. TGFBR1 is a major causative gene, mediating disease progression through dysregulated transforming growth factor-β signaling; however, its role in left ventricular systolic function remains unclear. …

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Identification of the Carcinogenic Process from Lobular Endocervical Glandular Hyperplasia to Gastric-Type Adenocarcinoma of the Uterine Cervix via Whole-Exome Sequencing

Airi Kuruma, Tatsuo Masuda, Kazuaki Sato, Kansuke Kido et autres

Background: Gastric-type adenocarcinoma (GAS) of the uterine cervix is a rare malignancy with poor clinical outcomes. However, the carcinogenic processes involved remain unclear. Methods: Normal cervical glands, lobular endocervical glandular hyperplasia (LEGH), and GAS from the same patients were collected using laser …

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Successful creation of an arteriovenous fistula and pathological evaluation of the radial artery in an end-stage kidney disease patient with Marfan syndrome: a case report

Hiroki Okushima, Akihiro Imai, Ayumi Matsumoto, Kazunori Inoue et autres

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Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma

Shu Aoyama, Takehiro Noda, Hirofumi Akita, Yosuke Mukai et autres

BACKGROUND: Tumor-infiltrating lymphocytes (TILs) are essential to effective immunotherapy for hepatocellular carcinoma (HCC). Among factors regulating TILs, tumor-associated high endothelial venules (TA-HEVs) have been identified in various cancers and may contribute to TIL recruitment. This study aimed to investigate the clinical significance …

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Computed tomography–derived elastic modulus as a noninvasive marker of aortic wall integrity: Correlation with histopathology in the ascending aorta

Fumio Yamana, Kazuo Shimamura, Takuji Kawamura, Takashi Shirakawa et autres

Background: Ascending aortic aneurysms and dissections are life-threatening conditions often requiring prophylactic surgeries. Current guidelines rely primarily on aortic diameter for intervention; however, many dissections occur without severe dilation. Mechanical properties, such as elastic modulus, have emerged as potential predictors of disease …

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Computed Tomography-Derived Elastic Modulus as a Noninvasive Marker of Aortic Wall Integrity: Correlation with Histopathology in the Ascending Aorta

Fumio Yamana, Kazuo Shimamura, Takuji Kawamura, Takashi Shirakawa et autres

Abstract Background Ascending aortic aneurysms and dissections are life-threatening conditions often requiring prophylactic surgeries. Current guidelines rely primarily on aortic diameter for intervention; however, many dissections occur without severe dilation. Mechanical properties, such as elastic modulus have emerged as potential predictors of …

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Assessment of endometrial cancer with microcystic, elongated, and fragmented pattern invasion using multiparametric MRI

Koki Kaketaka, Takahiro Tsuboyama, Hideyuki Fukui, Shohei Matsumoto et autres

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Perioperative Treatment of Metachronous Multiple Lung Cancer with Organizing Pneumonia: A Case Report

Hiroshi Takehara, Ken Kodama, Toru Momozane, Kansuke Kido

We report a rare case of the independent coexistence of lung cancer and organizing pneumonia (OP) in different lobes of the right lung in a 67-year-old man with a history of left upper lobectomy. Computed tomography revealed a lesion consistent with OP …

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Histopathologic Comparison Among Drug Eruptions Induced by Enfortumab Vedotin, Brentuximab Vedotin, and Taxanes

Yoshifumi Iwahashi, Keisuke Goto, Shuichi Ohe, Shota Bun et autres

ABSTRACT: Microtubule-stabilizing agents (enfortumab vedotin and brentuximab vedotin) and microtubule-disrupting agents (docetaxel and paclitaxel) are used as anticancer agents but can also induce drug eruptions. Recently, mitotic arrest figures have been reported in various non-neoplastic cells as the histopathologic side effect of …

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Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity

Koto Ukon, Satoshi Nojima, Daisuke Motooka, Tsuyoshi Takashima et autres

Interstitial pneumonia (IP) is a refractory disease that causes severe inflammation and fibrosis in the interstitium of the lungs, often resulting in the development of lung cancer (LC) during treatment. Previous studies have demonstrated that the prognosis of LC complicated by IP …

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Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis

Shinichiro Tahara, Kazuaki Sato, Kansuke Kido, Eiichi Morii

One of the known histological patterns of endometrioid carcinoma (EC) in uterine corpus cancer is MELF (microcystic, elongated, and fragmented). MELF is associated with lymphovascular invasion and lymph node metastasis. Besides MELF, it is also known that squamous differentiation (SD) often occurs …

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Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α

Daisuke Umeda, Akikazu Harada, Daisuke Motooka, Shinichiro Tahara et autres

Micropapillary adenocarcinoma (MPC) is an aggressive histological subtype of lung adenocarcinoma (LUAD). MPC is composed of small clusters of cancer cells exhibiting inverted polarity. However, the mechanism underlying its formation is poorly understood. Here we show that hypoxia is involved in MPC …

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