Computed Tomography-Derived Elastic Modulus as a Noninvasive Marker of Aortic Wall Integrity: Correlation with Histopathology in the Ascending Aorta
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Le résumé fourni par la source
Abstract Background Ascending aortic aneurysms and dissections are life-threatening conditions often requiring prophylactic surgeries. Current guidelines rely primarily on aortic diameter for intervention; however, many dissections occur without severe dilation. Mechanical properties, such as elastic modulus have emerged as potential predictors of disease progression; nonetheless, noninvasive clinical applications remain limited. This study evaluated the relationship between the computed tomography (CT)-derived elastic modulus of the ascending aorta and the histopathological characteristics of the aortic media. Methods Thirty patients who underwent surgical ascending aorta replacement were included in this study. Preoperative CT was used to calculate the aortic elastic modulus based on geometric measurements and pulse pressure. Resected aortic specimens were subjected to histological and immunohistochemical analyses to assess elastin, collagen, vascular smooth muscle cells (VSMCs), and smoothelin expression. Correlation analyses between the CT-derived elastic modulus and aortic media composition were conducted after adjusting for age and aortic diameter. Results The CT-derived elastic modulus exhibited a significant negative correlation with elastin area and a positive correlation with collagen area. Additionally, a moderate negative correlation was observed between the elastic modulus and elastin fiber waviness. A strong negative correlation was detected between the elastic modulus and the proportion of contractile-type (smoothelin-positive) VSMCs. These findings remained significant after adjusting for confounders. Conclusions CT-derived elastic modulus of the ascending aorta reflects the underlying pathological changes, including extracellular matrix remodeling and VSMC phenotypic modulation. Noninvasive assessment of aortic mechanical properties may provide novel insights into aortic disease progression and therapeutic responses.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Computed Tomography-Derived Elastic Modulus as a Noninvasive Marker of Aortic Wall Integrity: Correlation with Histopathology in the Ascending Aorta
- Date Crossref
- 01/07/2025
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Suita Tokushukai Hospital pays non établi dans la noticeÉtablissement de santé
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Osaka University of Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Osaka City University pays non établi dans la noticeUniversité ou école supérieure
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Osaka Daigaku Daigakuin Igakukei Kenkyuka Igakubu Igaku Senko Renkei Daigakuin pays non établi dans la noticeInstitution
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Osaka University Graduate School of Medicine Department of Cardiovascular Surgery pays non établi dans la noticeUniversité ou école supérieure
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Osaka Keisatsu Hospital pays non établi dans la noticeÉtablissement de santé
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Osaka Daigaku Igakubu Fuzoku Byoin pays non établi dans la noticeInstitution
The University of Osaka, Suita Tokushukai Hospital et Osaka University of Pharmaceutical Sciences, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.