Tatsuo Masuda

Abstract 2033: LSR suppresses ferroptosis through alpha-tocopherol uptake and promotes tumor growth in gynecological cancers.

Masashi Akada, Kosuke Hiramatsu, Yoshikazu Nagase, Tatsuo Masuda et autres

Abstract Background: Lipolysis-stimulated lipoprotein receptor (LSR) plays an important role in lipid uptake and is overexpressed in gynecologic cancers, where its high levels are correlated with unfavorable outcomes. However, the lipid metabolic mechanisms via LSR are not well understood. In this study, …

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Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/ mTOR signaling pathway in epithelial ovarian cancer

Hitomi Sakaguchi-Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda et autres

Abstract Epithelial ovarian cancer (EOC) is a highly aggressive malignancy with poor prognosis. Thus, new treatment options are needed. Recently, lipid metabolism in EOC has been highlighted. However, the specific lipid molecules activating lipid metabolism remain unclear. This study aimed to elucidate …

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Identification of the Carcinogenic Process from Lobular Endocervical Glandular Hyperplasia to Gastric-Type Adenocarcinoma of the Uterine Cervix via Whole-Exome Sequencing

Airi Kuruma, Tatsuo Masuda, Kazuaki Sato, Kansuke Kido et autres

Background: Gastric-type adenocarcinoma (GAS) of the uterine cervix is a rare malignancy with poor clinical outcomes. However, the carcinogenic processes involved remain unclear. Methods: Normal cervical glands, lobular endocervical glandular hyperplasia (LEGH), and GAS from the same patients were collected using laser …

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LSR-mediated alpha-tocopherol uptake inhibits ferroptosis and promotes tumor growth in gynecological cancers

Masashi Akada, Kosuke Hiramatsu, Yoshikazu Nagase, Tatsuo Masuda et autres

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P.57: Amniotic membrane bank activities for amniotic membrane transplantation at the University of Osaka Hospital.

Takeshi Soma, Hiroshi Takayanagi, Masahiro Kitao, Rei Kamuro et autres

The University of Osaka Hospital Amniotic Membrane Bank. Introduction: The Amniotic Membrane (AM) Bank at The University of Osaka Hospital (UOH) was established in 2017. The AM has been shown to offer significant benefits in ophthalmic treatments owing to its anti-inflammatory, anti-fibrotic, …

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Supplementary Information from Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers

Shinichi Namba, Yuki Saito, Yasunori Kogure, Tatsuo Masuda et autres

Figures S1–S11, Tables S1–S6, Supplementary Materials and Methods, Supplementary Notes, and Supplementary References

REAL-WORLD UTILIZATION OF TRADITIONAL JAPANESE KAMPO MEDICINE AS SUPPORTIVE CARE IN PATIENTS UNDERGOING CHEMOTHERAPY

Satoshi Nakagawa, Yutaka Ueda, Maki Nakai, Tatsuo Masuda et autres

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VRK1 Is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix

Mariya Kobayashi, Satoshi Nakagawa, Yusuke Ishii, Yuji Kamei et autres

Small cell neuroendocrine carcinoma of the cervix (SCNEC) is classified as a high-grade neuroendocrine carcinoma with a worse prognosis than other major histological types of cervical cancer. Identifying novel therapeutic targets based on its molecular characteristics is highly desirable but challenging due …

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The value of vaginal cytology for postoperative surveillance of endometrial cancer

Eiji Kobayashi, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa et autres

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Clinical and pathological characteristics and outcomes of small cell neuroendocrine carcinoma of the uterine cervix

Mariya Kobayashi, Satoshi Nakagawa, Tatsuo Masuda, Mamoru Kakuda et autres

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A ninth-year follow-up survey of attitudes and behaviors of obstetricians and gynecologists toward HPV vaccination in Japan

Maki Nakai, Emiko Oka, Yutaka Ueda, Asami Yagi et autres

The Japanese government suspended its proactive recommendation for routine HPV vaccination for nine years, from June 2013 to May 2022, due to concerns about unconfirmed reports of adverse events. This study represents the fifth in our ongoing series of surveys assessing Japanese …

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Abstract 5566: Comprehensive protein and genomic analysis demonstrate IGF2BP2 promotes cell proliferation via NF-kB signaling pathway in endometrial cancer

Hiroki Kurahashi, Yuko Watanabe, Kosuke Hiramatsu, Tatsuo Masuda et autres

Introduction: Endometrial cancer (EC) is the most common gynecological cancer. While multidisciplinary therapy including surgery and chemotherapy improves the prognosis, that of refractory cases remains poor. In this study, we aimed to investigate the new treatment target and predictive marker for treatment …

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