Susumu Misugi

Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients

Hirofumi Soejima, Hisao Ogawa, Takeshi Morimoto, Sadanori Okada et autres

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Kidney function deterioration is dependent on blood pressure levels: 11.2 year follow-up in diabetic patients

Hirofumi Soejima, Hisao Ogawa, Takeshi Morimoto, Sadanori Okada et autres

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Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial

Chisa Matsumoto, Hisao Ogawa, Yoshihiko Saito, Sadanori Okada et autres

OBJECTIVE To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women. RESEARCH DESIGN AND METHODS This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin …

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Effect of Aspirin on Cancer Chemoprevention in Japanese Patients With Type 2 Diabetes: 10-Year Observational Follow-up of a Randomized Controlled Trial

Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma et autres

OBJECTIVE This study analyzed the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes. RESEARCH DESIGN AND METHODS This study was a posttrial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial. Participants in the …

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Studies on Three Kindreds with Familial Hypercholesterolemia and Xanthomatosis; Genetic, Clinical and Pathogenic Aspects

Taku Yamamura, Hiroshi Sudo, Susumu Misugi, Yūji Matsuzawa et autres

Atherosclerosis and xanthomatosis are frequently associated with familial hyperbetalipoproteinemia. In this report, we present three kindreds (SS, YS and N) with familial hypercholesterolemia and xanthomatosis. Two probands (S. S. and Y. S.) were born to consanguineous marriages. S. S., 17-yr-old female, and …

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Fatty Acid Composition of Phospholipids in Human Serum Lipoprotein Fractions

Akira Yamamoto, Katsunori ISHIKAWA, Yūji Matsuzawa, Susumu Misugi et autres

The major fatty acids of sphingomyelin in human serum are palmitic (16 : 0) and nervonic (24 : 1) acids. There was a marked difference in distribution of fatty acids between lipoprotein fractions in normal subjects. The concentration of 24 : 1 …

Serum Lipoprotein Patterns and The Glucose Tolerance Test in Obese Children

Hiroshi Sudo, Katsunori ISHIKAWA, Taku Yamamura, Susumu Misugi et autres

Our previous studies showed that adult obese subjects, like patients with arteriosclerosis and cholelithiasis, has a decrease in α-lipoprotein and an incresae in β/α ratio of lipoprotein cholesterol, even if the total serum cholesterol level was in normal range.In this study, analysis …

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Serum-lipoprotein Patterns in Ischemic Heart Disease, Cerebral Arteriosclerosis, Cholelithiasis and Obesity

Hiroshi Sudo, Yūji Matsuzawa, Susumu Misugi, Taku YAMAMURA et autres

Analysis of serum lipoprotein was performed in normal subjects and patients with ischemic heart disuse, cerebral arteriosclerosis, cholelithiasis and obesity.There were several differences between male and female; (1) Female showed a significantly higher level of α-lipoprotein cholesterol and a lower β/α ratio …

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Long-term Treatment of Hyperlipidemia with a Nicotinic Acid Derivative and the Overt Alcohol-induced Hyperlipemia during the Course of Treatment

Akira Yamamoto, Katsunori ISHIKAWA, Yūji Matsuzawa, Susumu Misugi

Nicomol [2, 2, 6, 6-tetrakis (nicotinyloxymethyl)-cyclohexanol], a derivative of nicotinic acid, was given to 25 patients with hyperlipidemia of type IIa, IIb or IV at a level of 0.6-1.2g per day for 8-32 months. Facial flush, erythema and itching of the skin …

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Plasma-lipoprotein Patterns in Coronary and Cerebral Vascular Diseases, Gallstones and Obesity

Akira Yamamoto, Katsunori ISHIKAWA, Yūji Matsuzawa, Susumu Misugi et autres

It has been established that there is a close relationship between hypercholesterolemia and coronary heart disease. But cerebral vascular disorders (arteriosclerosis and thrombosis) are rather common in area where people live in poor nutritional conditions. The serum-cholesterol level in cerebral thrombosis is …

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