Yūji Matsuzawa

Association of Serum Soluble T-cadherin Levels with Metabolic Syndrome in Japanese Participants Undergoing Health Checkups

Ryohei Mineo, Shiro Fukuda, Masahito Iioka, Hitoshi Nishizawa et autres

AIMS: Visceral fat accumulation is the central feature of metabolic syndrome and subsequent atherosclerotic cardiovascular disease. Soluble T-cadherin (sT-cad) has been identified in circulation, but its clinical significance in the general population remains unclear. We investigated the associations of circulating sT-cad levels …

jp, ru (code pays fourni par la source)

A Man with Primary Hyperchylomicronemia with Triglyceride Levels Exceeding 11,000 mg/dL Was Well Controlled by Pemafibrate Combined with Dietary Therapy

Hiroyuki Ueda, Ryohei Mineo, Takuya Sugiyama, Masahiro Koseki et autres

A 50-year-old man with a triglyceride (TG) level of 11,397 mg/dL was admitted to our hospital. He consumed a high-fat and high-carbohydrate diet as well as more than 100 g of alcohol per day. He had type 2 diabetes and obesity and …

jp (code pays fourni par la source)

Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission

Ryohei Mineo, Shiro Fukuda, Shigehito Suzuki, Yoshito Ito et autres

At the beginning of 2020, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to epidemics worldwide. Obesity and visceral fat accumulation have been reported to be independent risk factors for severe COVID-19. Several reports have focused …

jp (code pays fourni par la source)

Myocardial fat accumulation is associated with cardiac dysfunction in patients with type 2 diabetes, especially in elderly or female patients: a retrospective observational study

Risa Kashiwagi-Takayama, Junji Kozawa, Yoshiya Hosokawa, Sarasa Kato et autres

BACKGROUND: Ectopic fat is fat that accumulates in or around specific organs or compartments of the body including myocardium. The clinical features of type 2 diabetes patients with high fat accumulation in the myocardium remain unknown. Moreover, little is known about the …

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The 100th Anniversary of the Foundation of the Japan Endocrine Society—The Proposal of Adipoendocrinology

Yūji Matsuzawa

jp (code pays fourni par la source)

Increase in glycemic set point, alongside a decrease in waist circumference, in the non-diabetic population during the Japanese National Intervention Program for metabolic syndrome: A single-center, large-scale, matched-pair analysis

Takuya Sugiyama, Yuya Yamada, Yoshito Ito, Ryohei Mineo et autres

BACKGROUND: In 2008, the Japanese government implemented a National Intervention Program for metabolic syndrome. Low-risk individuals were not direct targets of this intervention. Nevertheless, they were indirectly enlightened by this massive campaign. Documentation of the metabolic shifts in low-risk individuals following the …

jp (code pays fourni par la source)

The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples

Jun Muratsu, Kei Kamide, Takashi Fujimoto, Yasushi Takeya et autres

Background: Adipokine dysregulation is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Low adiponectin levels are associated with higher risks of cardiovascular diseases (CVD). However, high adiponectin levels have also been associated with increased all-cause and cardiovascular …

jp (code pays fourni par la source)

Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT

Hidenori Arai, Hideaki Bujo, Daisaku Masuda, Toshiyuki Ishibashi et autres

AIMS: In this study, we integrated two randomized control trials, PROSPECTIVE and IMPACT, to address the effect of probucol on cerebrocardiovascular events and carotid intima-media thickness (IMT) in Japanese, Korean, and Chinese patients with coronary artery disease (CAD). METHODS: A total of …

jp, us, kr, Éthiopie, cn (code pays fourni par la source)

Adiposity measures and mortality in an Asian population

Shizuya Yamashita, Yūji Matsuzawa

jp (code pays fourni par la source)

Gaps in beliefs and practice in dyslipidaemia management in Japan, Germany, Colombia and the Philippines: insights from a web-based physician survey

Philip J. Barter, Shizuya Yamashita, Ulrich Laufs, Álvaro J. Ruiz et autres

BACKGROUND: Implementing evidence-based management of dyslipidaemia is a challenge worldwide. OBJECTIVES: To understand physician beliefs and behaviour and identify uncertainties in dyslipidaemia management across four world regions. METHODS: Web-based survey of 1758 physicians in Japan, Germany, Colombia and the Philippines who were …

au, jp, de, co, ph, it, se, us, br (code pays fourni par la source)

New Horizons for Probucol, an Old, Mysterious Drug

Shizuya Yamashita, Daisaku Masuda, Yūji Matsuzawa

Intensive low-density lipoprotein (LDL)-lowering therapies involving statins, intestinal cholesterol transporter inhibitor (ezetimibe), and proprotein convertase subtilisin/kexin type 9 inhibitors are associated with a significantly lower number of atherosclerotic cardiovascular events.However, these events have not been completely prevented to date.Therefore, additional pharmacological interventions …

jp (code pays fourni par la source)

Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE)

Shizuya Yamashita, Hidenori Arai, Hideaki Bujo, Daisaku Masuda et autres

AIMS: Although intensive statin therapy reduced cardiovascular risks, cardiovascular events have not been completely prevented. Probucol is a potent antioxidant and reduces tendon xanthomas in familial hypercholesterolemia patients despite reduction of high-density lipoprotein (HDL)-cholesterol (HDL-C). We investigated whether probucol can reduce cardiovascular …

jp, ca, us (code pays fourni par la source)