Serum-lipoprotein Patterns in Ischemic Heart Disease, Cerebral Arteriosclerosis, Cholelithiasis and Obesity

Le résumé fourni par la source

Analysis of serum lipoprotein was performed in normal subjects and patients with ischemic heart disuse, cerebral arteriosclerosis, cholelithiasis and obesity.There were several differences between male and female; (1) Female showed a significantly higher level of α-lipoprotein cholesterol and a lower β/α ratio than male. (2) An increase in β/α ratio took place with an increase in concentration of total serum cholesterol in male but there was no correlation between total cholesterol and β/α ratio in female.Not only in ischemic heart disease which is usually accompanied with hypercholesterolemia but in cerebral arteriosclerosis, cholelithiasis and obesity, even if the serum cholesterol level was in normal range, the concentration of α-lipoprotein cholesterol in serum was lower and the β/α ratio of lipoprotein cholesterol was significantly higher than in normal subjects.The effect of estrogen on serum lipoprotein was followed in six hypercholesterolemic subjects (Type IIa). α-Lipoprotein cholesterol was increased and the β/α ratio decreased in two female at early climacteric stage. But, two male and two aged female did not show a change in serum lipid pattern.Following the weight reduction in obese patients, there were decreases in total cholesterol, β-lipoprotein cholesterol and triglyceride and an increase in α-lipoprotein cholesterol.

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