Patrick Schaefer

Toward the next 20 years of Cell Metabolism

Salvatore Fabbiano, Beste Mutlu, Patrick Schaefer, Yongmei Sun

High Precision Quantification of small RNA Slicing Activity - Native Index Ligation-based Targeted Degradome Sequencing (NIL-TDS)

B. Werner, Sabrine Nasfi, Michael Lienhard Schmitz, Manar Makhoul et autres

ABSTRACT RNA interference (RNAi) is an effective and precise regulatory mechanism in eukaryotes in which small RNAs mediate endonucleolytic slicing of complementary target mRNAs. Despite the potential of RNAi for human therapeutics and crop bio-protection, analytical platforms to quantitatively validate the slicing …

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Development and evaluation of an e-learning curriculum on drug-related problems for community pharmacists

Marina Weißenborn, Viktoria Sophie Wurmbach, Janina A. Bittmann, Robert Moecker et autres

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Mitophagy-Related Cell Death Mediated by Vacquinol-1 and TRPM7 Blockade in Glioblastoma IV

Philip Sander, Paul Walther, Barbara Moepps, M. Hinz et autres

Glioblastoma IV (GBM) is one of the deadliest malignant diseases in adults and is characterized by a high mutation rate and multiple traits to suppress inborn and acquired immunity. We here approached autophagy-related cell death in newly established GBM cell lines derived …

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Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration

Patrick Schaefer, Bjoern von Einem, Paul Walther, Enrico Calzia et autres

One hallmark of Alzheimer´s disease are senile plaques consisting of amyloid beta (Aβ), which derives from the processing of the amyloid precursor protein (APP). Mitochondrial dysfunction has been linked to the pathogenesis of Alzheimer´s disease and both Aβ and APP have been …

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Promotor-Hypermethylierung von SHOX2 und SEPT9 als Biomarker im Gallengangskarzinom

Vittorio Branchi, Patrick Schaefer, Philipp Lingohr, Albert Semaan et autres

Einleitung/Ziel: Gallengangskarzinome (GGK) weisen trotz intensiver Forschung immer noch eine schlechte Prognose auf. Die einzige kurative Therapiemöglichkeit ist eine radikale chirurgische Resektion in einem frühen Tumorstadium. Eine frühzeitige Diagnose stellt aufgrund des späten Auftretens von Symptomen jedoch eine Herausforderung dar. Neue molekulare …

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Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

Alberto Capurro, Liviu‐Gabriel Bodea, Patrick Schaefer, Ruth Luthi‐Carter et autres

The characterization of molecular changes in diseased tissues gives insight into pathophysiological mechanisms and is important for therapeutic development. Genome-wide gene expression analysis has proven valuable for identifying biological processes in neurodegenerative diseases using post mortem human brain tissue and numerous datasets …

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Diversity and Ecological Structure of Northern Biting Flies

Patrick Schaefer

Contemporary climate change disproportionately impacts northern environments. Understanding these impacts requires knowledge of the ecological structure (e.g. diversity, abundance and distribution) of resident species. Biting flies are among the best-known groups of insects in northern Canada and are excellent sentinels for environmental …

Reprogramming of plant cells by filamentous plant‐colonizing microbes

Gunther Doehlemann, Natalia Requena, Patrick Schaefer, Frédéric Brunner et autres

Although phylogenetically unrelated, filamentous oomycetes and fungi establish similar structures to colonize plants and they represent economically the most important microbial threat to crop production. In mutualistic interactions established by root-colonizing fungi, clear differences to pathogens can be seen, but there is …

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Confirmatory analysis of ethylglucuronide in urine by liquid-chromatography/electrospray ionization/tandem mass spectrometry according to forensic guidelines

Wolfgang Weinmann, Patrick Schaefer, Annette Thierauf, André Schreiber et autres

beta-D-ethylglucuronide (EtG) is a stable Phase II metabolite of ethanol which can be detected in urine samples several days after elimination of ethanol. It is a useful diagnostic parameter for monitoring abstinence of alcoholics in alcohol withdrawal treatment. For this purpose, determination …

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