Yue-Zhong Wu

Assessment of EBV DNA methlyation to guide antiviral use in EBV-associated lymphoma

Christoph Weigel, Haley Klimaszewski, Kurtis M. Host, Yue-Zhong Wu et autres

Abstract Intro/Objective: Epstein-Barr Virus (EBV), an oncogenic herpesvirus, can drive human lymphoma development. EBV uses DNA methylation to silence its genome, switching from a lytic (active) to a latent (dormant) state, and it's widely understood that EBV remains latent in lymphoma. Current …

us (code pays fourni par la source)

Abstract A006: Assessment of EBV DNA methylation to guide antiviral use in EBV-associated lymphoma

C. Noël, Christoph Weigel, Haley Klimaszewski, Ada C. Sher et autres

Abstract Introduction/Objective: Epstein-Barr Virus (EBV) is an oncogenic herpesvirus driving development of human lymphomas. EBV uses DNA methylation to silence its genome and switch from a lytic (actively replicating) to a latent (dormant) state. Clinical treatment decisions for EBV-associated (EBV+) lymphomas are …

us (code pays fourni par la source)

Abstract 3242: DNA methylation profiling of Epstein-Barr virus (EBV) in lymphoproliferative disease reveals diagnostic and therapeutic applications

Christoph Weigel, Haley Klimaszewski, Ada C. Sher, Kurtis M. Host et autres

Abstract Introduction: Epstein-Barr Virus (EBV) is an oncogenic herpesvirus linked to hematologic malignancies. EBV enters latency within host cells and can undergo lytic activation, resulting in release of infectious virions. Latent EBV mediates malignant transformation, while lytic EBV is a frequent complication …

us (code pays fourni par la source)

DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia

Brian Giacopelli, Min Wang, Ada C Cleary, Yue-Zhong Wu et autres

Acute myeloid leukemia (AML) is a molecularly complex disease characterized by heterogeneous tumor genetic profiles and involving numerous pathogenic mechanisms and pathways. Integration of molecular data types across multiple patient cohorts may advance current genetic approaches for improved subclassification and understanding of …

us, de (code pays fourni par la source)

Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia

Brian Giacopelli, Qiuhong Zhao, Amy S. Ruppert, Akwasi Agyeman et autres

Alterations in global DNA methylation patterns are a major hallmark of cancer and represent attractive biomarkers for personalized risk stratification. Chronic lymphocytic leukemia (CLL) risk stratification studies typically focus on time to first treatment (TTFT), time to progression (TTP) after treatment, and …

us, de, ch (code pays fourni par la source)

Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia

Alison R. Walker, Hongyan Wang, Katherine Walsh, Bhavana Bhatnagar et autres

Targeting aberrant tyrosine kinase activity may impact clinical outcome in acute myeloid leukemia (AML). We conducted a phase I study of the tyrosine kinase inhibitor midostaurin with bortezomib alone and in combination with chemotherapy in patients with AML. Patients on dose levels …

us (code pays fourni par la source)

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

Houda Alachkar, Ramasamy Santhanam, Kati Maharry, Klaus H. Metzeler et autres

Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue remodeling, is associated with a variety of diseases including cancer, but the contribution of SPARC to malignant growth remains controversial. We …

us (code pays fourni par la source)

Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score

Guido Marcucci, Pearlly S. Yan, Kati Maharry, David Frankhouser et autres

PURPOSE: Molecular risk stratification of acute myeloid leukemia (AML) is largely based on genetic markers. However, epigenetic changes, including DNA methylation, deregulate gene expression and may also have prognostic impact. We evaluated the clinical relevance of integrating DNA methylation and genetic information …

de (code pays fourni par la source)

Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation

Anjali Mishra, Shujun Liu, Gregory H. Sams, Douglas P. Curphey et autres

us (code pays fourni par la source)

Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia

Pearlly S. Yan, David Frankhouser, Mark W. Murphy, Hok-Hei Tam et autres

The outcome of older (≥ 60 years) acute myeloid leukemia (AML) patients is poor, and novel treatments are needed. In a phase 2 trial for older AML patients, low-dose (20 mg/m(2) per day for 10 days) decitabine, a DNA hypomethylating azanucleoside, produced …

us (code pays fourni par la source)

DNA methylation changes in a human cell model of breast cancer progression

Sandra V. Fernandez, Kara E. Snider, Yue-Zhong Wu, Irma H. Russo et autres

us, de (code pays fourni par la source)

Identification of Novel Methylation Markers in Cervical Cancer Using Restriction Landmark Genomic Scanning

Sophia Wang, Dominic J. Smiraglia, Yue-Zhong Wu, Srimoyee Ghosh et autres

Aberrant methylation of CpG islands in gene promoters often represents an early clonal event in carcinogenesis. Accordingly, defining methylation profiles may be useful for developing marker panels for early detection or predicting the risk of cancer precursors. To identify specific genes frequently …

us (code pays fourni par la source)