Christopher K. Rodesch

EPO improved neurologic outcome in rat pups late after traumatic brain injury

Michelle E. Schober, Daniela F. Requena, Christopher K. Rodesch

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Downmodulation of CCR7 by HIV-1 Vpu Results in Impaired Migration and Chemotactic Signaling within CD4+ T Cells

Peter W. Ramirez, Marylinda Famiglietti, Bharatwaj Sowrirajan, Ana Beatriz DePaula-Silva et autres

The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and …

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Erythropoietin Improved Cognitive Function and Decreased Hippocampal Caspase Activity in Rat Pups after Traumatic Brain Injury

Michelle E. Schober, Daniela F. Requena, Benjamin Block, Lizeth J. Davis et autres

UNLABELLED: Traumatic brain injury (TBI) is a leading cause of acquired neurologic disability in children. Erythropoietin (EPO), an anti-apoptotic cytokine, improved cognitive outcome in adult rats after TBI. To our knowledge, EPO has not been studied in a developmental TBI model. HYPOTHESIS: …

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Effects of Redox State on the Efficient Uptake of Cell Permeable Peptide in Mammalian Cells

Shayne Squires, Elisabeth Christians, Michael Riedel, D. H. Timothy et autres

We investigated whether a cell-penetrating peptide linked via a disulfide bond to a fluorophore-labeled cargo peptide can be used to interrogate changes in cellular redox state. A fluorescence resonance energy transfer (FRET) pair was constructed so that the cargo peptide was labeled …

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Correction to the Supporting Information of Real-Time Fluorescent Image Analysis of DNA Spot Hybridization Kinetics to Assess Microarray Spot Heterogeneity

Archana N. Rao, Christopher K. Rodesch, David W. Grainger

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to the Supporting Information of Real-Time Fluorescent Image Analysis of DNA Spot Hybridization Kinetics to Assess Microarray Spot HeterogeneityArchana N. Rao, Christopher K. Rodesch, and David W. Grainger*Cite this: Anal. Chem. 2013, 85, …

Real-Time Fluorescent Image Analysis of DNA Spot Hybridization Kinetics To Assess Microarray Spot Heterogeneity

Archana N. Rao, Christopher K. Rodesch, David W. Grainger

Current microarray assay technology predominately uses fluorescence as a detectable signal end point. This study assessed real-time in situ surface hybridization capture kinetics for single printed DNA microspots on solid array surfaces using fluorescence. The influence of the DNA target and probe …

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Erratum To: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

Eiji Morita, Virginie Sandrin, Hyo-Young Chung, Scott G. Morham et autres

Quantification of dystrophin immunofluorescence in dystrophinopathy muscle specimens

L. E. Taylor, Yuuki Kaminoh, Christopher K. Rodesch, Kevin M. Flanigan

AIMS: Duchenne muscular dystrophy (DMD) is usually associated with absent or nearly absent dystrophin expression at the sarcolemmal membrane. Quantification of very low levels of dystrophin signal in immunofluorescent studies of muscle biopsy sections presents a technical challenge. This is particularly true …

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Glutathione‐dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

Huali Zhang, Pattraranee Limphong, Joel Pieper, Qiang Liu et autres

To investigate the effects of the predominant nonprotein thiol, glutathione (GSH), on redox homeostasis, we employed complementary pharmacological and genetic strategies to determine the consequences of both loss- and gain-of-function GSH content in vitro. We monitored the redox events in the cytosol …

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Exploiting antitumor immunity to overcome relapse and improve remission duration

Lei L. Chen, Xinjian Chen, Hongxun Sang, Hongbo Zhang et autres

Cancer survivors often relapse due to evolving drug-resistant clones and repopulating tumor stem cells. Our preclinical study demonstrated that terminal cancer patient's lymphocytes can be converted from tolerant bystanders in vivo into effective cytotoxic T-lymphocytes in vitro killing patient's own tumor cells …

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P1.46 Quantification of immunofluorescent signal intensity in dystrophinopathy muscle specimens

Lauren Taylor, Yuuki Kaminoh, Christopher K. Rodesch, Kevin M. Flanigan

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Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

Eiji Morita, Leremy A. Colf, Mary Anne Karren, Virginie Sandrin et autres

The ESCRT pathway helps mediate the final abscission step of cytokinesis in mammals and archaea. In mammals, two early acting proteins of the ESCRT pathway, ALIX and TSG101, are recruited to the midbody through direct interactions with the phosphoprotein CEP55. CEP55 resides …

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