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Profil bibliographique

Elisabeth Christians

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

79Publications signalées
3833Citations signalées
0Affiliations récentes

Les domaines associés

Heat shock proteins researchGenetics, Aging, and Longevity in Model OrganismsReproductive Biology and FertilityAnimal Genetics and ReproductionEndoplasmic Reticulum Stress and Disease

Les publications récentes

Accès ouvert 2022 article OpenAlex

Acquisition of the spindle assembly checkpoint and its modulation by cell fate and cell size in a chordate embryo

Marianne Roca, Lydia Besnardeau, Elisabeth Christians, Alex McDougall et autres

The spindle assembly checkpoint (SAC) is a surveillance system that preserves genome integrity by delaying anaphase onset until all chromosomes are correctly attached to spindle microtubules. Recruitment of SAC proteins to unattached kinetochores generates an inhibitory signal that prolongs mitotic duration. Chordate …

fr (code pays fourni par la source)

5 citations Development
Accès ouvert 2022 preprint OpenAlex

Acquisition of the Spindle Assembly Checkpoint and its modulation by cell fate and cell size in a chordate embryo

Marianne Roca, Lydia Besnardeau, Elisabeth Christians, Alex McDougall et autres

Abstract The spindle assembly checkpoint (SAC) is a surveillance system which preserves genome integrity by delaying anaphase onset until all chromosomes are correctly attached to spindle microtubules. Recruitment of SAC proteins to unattached kinetochores generates an inhibitory signal that prolongs mitotic duration. …

fr, de (code pays fourni par la source)

1 citation bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2020 article OpenAlex

The Spindle Assembly Checkpoint Functions during Early Development in Non-Chordate Embryos

Janet Chênevert, Marianne Roca, Lydia Besnardeau, Antonella Ruggiero et autres

In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. …

fr, gb, it (code pays fourni par la source)

16 citations Cells
Accès ouvert 2019 article OpenAlex

Totipotency continuity from zygote to early blastomeres: a model under revision

Michele Boiani, Ellen Casser, Georg Fuellen, Elisabeth Christians

The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. However, if one asks about the totipotency of blastomeres after one or two zygotic divisions, opinions differ. As it is impossible to determine …

de, fr (code pays fourni par la source)

29 citations Reproduction
Accès ouvert 2019 preprint OpenAlex

The spindle assembly checkpoint functions during early development in non-chordate embryos

Janet Chênevert, Marianne Roca, Lydia Besnardeau, Antonella Ruggiero et autres

In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation. This control mechanism monitors proper attachment of chromosomes to spindle microtubules and delays mitotic progression if connections are erroneous or absent. The SAC operates in all eukaryotic cells tested so …

fr (code pays fourni par la source)

3 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2016 article OpenAlex

The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility

Katie A. Mitzelfelt, Pattraranee Limphong, Melinda J. Choi, Frances D. L. Kondrat et autres

Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to multisystem disorders featuring variable combinations of cataracts, cardiomyopathy, and skeletal myopathy. This study …

us, br, gb, cn, fr (code pays fourni par la source)

18 citations Journal of Biological Chemistry
Accès ouvert 2015 article OpenAlex

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome

Julianne H. Grose, Kelsey Murphey Langston, Xiaohui Wang, Shayne Squires et autres

Small Heat Shock Proteins (sHSPs) are molecular chaperones that transiently interact with other proteins, thereby assisting with quality control of proper protein folding and/or degradation. They are also recruited to protect cells from a variety of stresses in response to extreme heat, …

us (code pays fourni par la source)

13 citations PLoS ONE

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