Seong-Woon Yu

Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells

Jihyun Hong, Hyun‐Kyu An, Hyeri Nam, Jieun Choi et autres

Chronic psychological stress is a well-known risk factor for neurodegenerative diseases including Alzheimer disease (AD), yet the underlying mechanisms remain unclear. We previously showed that chronic stress impairs adult hippocampal neurogenesis by triggering autophagic cell death of adult hippocampal neural stem (HCN) …

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah, et al et autres

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it …

Attenuation of Translocator Protein 18 kDa (TSPO) Up-Regulation by Peroxisome Proliferator-Activated Receptor γ Ligand in Activated Microglia

Hyojin Cho, Hyun-Jung Shim, Seong-Woon Yu

Interplay between autophagy and programmed cell death in mammalian neural stem cells

Kyung Min Chung, Seong-Woon Yu

Mammalian neural stem cells (NSCs) are of particular interest because of their role in brain development and function. Recent findings suggest the intimate involvement of programmed cell death (PCD) in the turnover of NSCs. However, the underlying mechanisms of PCD are largely …

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, Fábio Camargo Abdalla, Hagai Abeliovich, Robert T. Abraham et autres

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been …

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Guidelines for the use and interpretation of assays for monitoring autophagy.

Daniel J. Klionsky, Fábio Camargo Abdalla, Hagai Abeliovich, Robert T. Abraham et autres

Comment in :The role of the Eph/ephrin-system in atherosclerotic plaque development: a complex puzzle. [Cardiovasc Pathol. 2014]

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Role of JNK activation in pancreatic β-cell death by streptozotocin

Hwanju Cheon, Jae Min Cho, Sunshin Kim, Seung‐Hoon Baek et autres

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Outer Mitochondrial Membrane Localization of Apoptosis-Inducing Factor: Mechanistic Implications for Release

Seong-Woon Yu, Yingfei Wang, D.S. Frydenlund, Ole Petter Ottersen et autres

Poly(ADP-ribose) polymerase-1-dependent cell death (known as parthanatos) plays a pivotal role in many clinically important events including ischaemia/reperfusion injury and glutamate excitotoxicity. A recent study by us has shown that uncleaved AIF (apoptosis-inducing factor), but not calpain-hydrolysed truncated-AIF, was rapidly released from …

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Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

Seong-Woon Yu, Shaida A. Andrabi, Hongmin Wang, No Soo Kim et autres

Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce cell death in response to poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation. How PARP-1 activation leads to AIF release is not known. Here we identify PAR polymer as a cell death …

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Poly(ADP-ribose) (PAR) polymer is a death signal

Shaida A. Andrabi, No Soo Kim, Seong-Woon Yu, Hongmin Wang et autres

Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays a prominent role in various of models of cellular injury. Here, we identify poly(ADP-ribose) (PAR) polymer, a product of PARP-1 activity, as a previously uncharacterized cell death signal. PAR polymer is directly …

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Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

Hongmin Wang, Mika Shimoji, Seong-Woon Yu, Ted M. Dawson et autres

Experimental intoxication models are used to study the more common sporadic form of Parkinson's disease (PD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) animal models of PD provide a valuable and predictive tool to probe the molecular mechanisms of dopamine neuronal cell death in PD. MPTP is …

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