Hyeri Nam

A human telomerase reverse transcriptase-derived peptide GV1001 rescues neurodegeneration in a mouse model of Alzheimer disease

Younghwan Lee, Hyeri Nam, J D Lee, Yeo Jin Ko et autres

GV1001 is a peptide consisting of 16 amino acids derived from the catalytic subunit of human telomerase reverse transcriptase. A recent phase II clinical trial in patients with Alzheimer disease (AD) showed that GV1001 effectively improved memory impairment with proven safety, leading …

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Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells

Jihyun Hong, Hyun‐Kyu An, Hyeri Nam, Jieun Choi et autres

Chronic psychological stress is a well-known risk factor for neurodegenerative diseases including Alzheimer disease (AD), yet the underlying mechanisms remain unclear. We previously showed that chronic stress impairs adult hippocampal neurogenesis by triggering autophagic cell death of adult hippocampal neural stem (HCN) …

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Presenilin 2 N141I Mutation Induces Hyperimmunity by Immune Cell-specific Suppression of REV-ERBα without Altering Central Circadian Rhythm

Hyeri Nam, Boil Kim, Young Hwan Lee, Han Kyoung Choe et autres

Circadian rhythm is a 24-hour cycle of behavioral and physiological changes.Disrupted sleep-wake patterns and circadian dysfunction are common in patients of Alzheimer Disease (AD) and are closely related with neuroinflammation.However, it is not well known how circadian rhythm of immune cells is …

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Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Hyeri Nam, Young Hwan Lee, Boil Kim, Ji-Won Lee et autres

Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigate how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-in (KI) …

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Dataset related to publication: Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Hyeri Nam, Seong‐Woon Yu

The datasets include raw data and analyzed DMR ratio from methylation sequencing.

kr (code pays fourni par la source)

Dataset related to publication: Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Hyeri Nam, Seong‐Woon Yu

The datasets include raw data and analyzed DMR ratio from methylation sequencing.

kr (code pays fourni par la source)

GSK3B induces autophagy by phosphorylating ULK1

Hye Young Ryu, Eun-Jung Kim, Hyeonjeong Jeong, Bo Kyoung Yeo et autres

Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian homolog of the yeast kinase Atg1, has an essential role in autophagy induction. In nutrient and growth factor signaling, ULK1 activity is regulated by various posttranslational modifications, including phosphorylation, acetylation, and ubiquitination. We previously …

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Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Hyeri Nam, Young Hwan Lee, Boil Kim, Ji‐Won Lee et autres

Abstract Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigated how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-in …

kr (code pays fourni par la source)

Cx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion

Young Hwan Lee, Ji‐Won Lee, Hyeri Nam, Seong‐Woon Yu

Abstract Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a Gαi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system including microglia, as well as intestinal and kidney macrophages. Cx3cr1CreERT2 mice express Cre recombinase …

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Translocator protein (TSPO): the new story of the old protein in neuroinflammation

Young Hwan Lee, Young‐Jin Park, Hyeri Nam, Ji‐Won Lee et autres

Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic …

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TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

Ji‐Won Lee, Hyeri Nam, Eun-Jung Kim, Yoonjeong Jeon et autres

Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and inflammation, as well as metabolism and cell survival. Diverse immune and inflammatory signals induce autophagy in macrophages through pattern …

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Suppression of autophagy through TLR4/PI3K/FoxO3 signaling impairs phagocytic degradation of microglia

Hyeri Nam