Accès ouvert
2025
article
OpenAlex
Jihyun Hong, Hyun‐Kyu An, Hyeri Nam, Jieun Choi et autres
Chronic psychological stress is a well-known risk factor for neurodegenerative diseases including Alzheimer disease (AD), yet the underlying mechanisms remain unclear. We previously showed that chronic stress impairs adult hippocampal neurogenesis by triggering autophagic cell death of adult hippocampal neural stem (HCN) …
kr
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Accès ouvert
2023
article
OpenAlex
So-Young An, Hyun‐Kyu An, Kyoung-Sook Kim, Young‐Choon Lee et autres
Abstract In current study, we addressed the anti-cancer effect of oleifolioside A and its mechanism on the regulation of cell death in HCT-116 human colorectal cancer cells. Oleifolioside A inhibited HCT-116 cell proliferation and caused apoptosis associated with sequential activation of caspases …
kr
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Accès ouvert
2023
article
OpenAlex
Seol-Hwa Jeong, Hyun‐Kyu An, Shinwon Ha, Seong‐Woon Yu
Autophagy is a cellular catabolic process that degrades and recycles cellular materials. Autophagy is considered to be beneficial to the cell and organism by preventing the accumulation of toxic protein aggregates, removing damaged organelles, and providing bioenergetic substrates that are necessary for …
kr
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Accès ouvert
2022
article
OpenAlex
Hyeri Nam, Young Hwan Lee, Boil Kim, Ji-Won Lee et autres
Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigate how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-in (KI) …
kr
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Accès ouvert
2021
article
OpenAlex
Hye Young Ryu, Eun-Jung Kim, Hyeonjeong Jeong, Bo Kyoung Yeo et autres
Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian homolog of the yeast kinase Atg1, has an essential role in autophagy induction. In nutrient and growth factor signaling, ULK1 activity is regulated by various posttranslational modifications, including phosphorylation, acetylation, and ubiquitination. We previously …
kr
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Accès ouvert
2020
preprint
OpenAlex
Hyeri Nam, Young Hwan Lee, Boil Kim, Ji‐Won Lee et autres
Abstract Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigated how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-in …
kr
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Eunhee Kim, Sungwoong Jeon, Hyun‐Kyu An, Mehrnoosh Kianpour et autres
There has been a great deal of interest in the development of technologies for actively manipulating neural networks in vitro, providing natural but simplified environments in a highly reproducible manner in which to study brain function and related diseases. Platforms for these …
kr
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Accès ouvert
2019
article
OpenAlex
Hyun‐Kyu An, Kyung Min Chung, HyunHee Park, Jihyun Hong et autres
CASP9 (caspase 9) is a well-known initiator caspase which triggers intrinsic apoptosis. Recent studies also suggest various non-apoptotic roles of CASP9, including macroautophagy/autophagy regulation. However, the involvement of CASP9 in autophagy and its molecular mechanisms are not well understood. Here we report …
kr
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2019
article
OpenAlex
Caroline Jeeyeon Hong, Jihye Yeon, Bo Kyoung Yeo, Hanwoong Woo et autres
Abstract Fas‐apoptotic inhibitory molecule 2 (FAIM2) is a member of the transmembrane BAX inhibitor motif–containing (TMBIM) family. TMBIM family is comprised of six anti‐apoptotic proteins that suppress cell death by regulating endoplasmic reticulum Ca 2+ homeostasis. Recent studies have implicated two TMBIM …
kr
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Accès ouvert
2019
article
OpenAlex
Jihyun Hong, Hyun‐Kyu An, Hyun-Hee Park, Seong‐Woon Yu
S375dysregulation of miRNAs are implicated in the pathophysiology of neurodegenerative disease and neurological disorders.Our findings, derived via miRNA-seq, indicate that expression of a subset of microRNAs are altered in postischemic CA1 including miR-34b/c, miR-21, miR-331, miR-181 and miR-29.Ingenuity pathway analysis reveals that …
kr
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Accès ouvert
2019
article
OpenAlex
Seonghee Jung, Seongwon Choe, Hanwoong Woo, Hyeonjeong Jeong et autres
S487induced by intraperitoneal injection of cisplatin 2 mg/kg twice a week for 5 consecutive weeks.The cisplatin-treated rats had reduced body weight, decreased heat sensitivity and slow nerve conduction velocity, indicating neuropathy.In the co-treatment group, curcumin 200 mg/kg/day was given once daily by …
kr
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Accès ouvert
2019
article
OpenAlex
Seonghee Jung, Seongwon Choe, Hanwoong Woo, Hyeonjeong Jeong et autres
Macroautophagy/autophagy is generally regarded as a cytoprotective mechanism, and it remains a matter of controversy whether autophagy can cause cell death in mammals. Here, we show that chronic restraint stress suppresses adult hippocampal neurogenesis in mice by inducing autophagic cell death (ACD) …
kr
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