Sakurako Tajiri

A randomized double-blind placebo-controlled trial of an inhibitor of plasminogen activator inhibitor-1 (TM5614) in mild to moderate COVID-19

Toyohiro Hirai, Koichiro Asano, Isao Ito, Yasunari Miyazaki et autres

An inhibitor of plasminogen activator inhibitor (PAI)-1, TM5614, inhibited thrombosis, inflammation, and fibrosis in several experimental mouse models. To evaluate the efficacy and safety of TM5614 in human COVID-19 pneumonia, phase IIa and IIb trials were conducted. In an open-label, single-arm trial, …

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Heart rate reduction during favipiravir therapy for hospitalized COVID-19 patients: experience from 6 cases

Megumi Shimada, Sakurako Tajiri, Raisuke Nishiyama, Hiroyuki Kato et autres

Favipiravir is an RNA polymerase inhibitor that was developed in Japan, and its antiviral effect is expected to be useful against coronavirus disease 2019 (COVID-19). We examined the therapeutic effect of favipiravir use for 6 patients with COVID-19. We analyzed body temperature, …

Sniff and reverse-sniff nasal respiratory pressures after exacerbation of chronic obstructive pulmonary disease: A single-center prospective study

Tsuyoshi Ichikawa, Sakurako Tajiri, Masanori Yokoba, Yu Horimizu et autres

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Dynamic Analysis of Aerosol Release from a Pressurized Metered Dose Inhaler Combined with a Valved Holding Chamber Using Simplified Laser Photometry

Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Sakurako Tajiri et autres

Background: A pressurized metered dose inhaler combined with a valved holding chamber (pMDI+VHC) is used to prevent upper airway complications and improve the efficiency of inhaled drug delivery; however, the aerodynamic behavior of the released particles has not been well investigated. This …

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Combination of computed tomography imaging pattern and severity of respiratory failure as factors associated with prognosis for acute exacerbation of idiopathic chronic fibrosing interstitial pneumonia

Keito Enokida, Takahisa Takihara, Yukihiro Horio, Noriko Nakamura et autres

BACKGROUND AND OBJECTIVES: The prognosis of idiopathic chronic fibrotic interstitial pneumonitis (CFIP) in patients with acute exacerbation (AE) is variable. We examined whether the imaging pattern on thoracic computed tomography (CT) or the severity of respiratory failure with AE-CFIP is associated with …

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In Vitro Comparison of Two Blister-Type Inhalers

Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Sakurako Tajiri et autres

BACKGROUND: Ellipta is a respiratory device that is a successor of the Diskus. A major difference between the devices is that Ellipta, especially the 2-strip type, includes a pair of blisters rather than a single blister as contained in Diskus. This study …

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Prognosis of acute exacerbation in idiopathic pulmonary fibrosis with pulmonary emphysema: a retrospective cohort study in Japan

Yukihiro Horio, Takahisa Takihara, Fuminari Takahashi, Keito Enokida et autres

OBJECTIVES: To analyse the clinical characteristics and prognosis of acute exacerbation (AE) in patients with idiopathic pulmonary fibrosis (IPF) and pulmonary emphysema. DESIGN: A multicentre retrospective cohort study SETTING: Two university hospitals in Japan PARTICIPANTS: Patients admitted to hospitals due to AE …

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Daily inhaled flow profiles and drug release from dry powder inhalers in patients with bronchial asthma

Sakurako Tajiri, Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino et autres

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[CHARACTERISTICS OF BUDEFORU® FOR BUDESONIDE AND FORMOTEROL MIXTURE].

Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Sakurako Tajiri et autres

BACKGROUND: (SMB), is widely used in Japan. Although appearance of BF resembles to SMB, several differences in length, weight, and side-hole sizes are seen with precise inspection. As particle releases from the inhalation device is strongly influenced by its mechanical characteristics, we …

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Daily Inspiratory Flow Patterns and Drug Release from Dry Powder Inhalers in Patients with Bronchial Asthma

Sakurako Tajiri, Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino et autres

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Optimal Inhalation Flow Pattern from Turbuhaler Predicted by Laser Photometry

Tetsuri Kondo, Makoto Hibino, Toshimori Tanigaki, Sakurako Tajiri et autres

Background: The emitted dose (ED) from most dry powder inhalers (DPIs) is almost independent of peak inspiratory flow (PIF) above a certain value, which is specific to the individual DPI. However, the ED of the Turbuhaler ® (TBH) increases linearly with PIF …

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Correcting Photo Reflection Method Output and Its Application in the Dynamic Analysis of Particle Release from Dry Powder Inhalers

Tetsuri Kondo, Makoto Hibino, Toshimori Tanigaki, Sakurako Tajiri et autres

Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalation flow rates …

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