Masanori Yokoba

WCN26-6372 β-OXIDATION AND GLUCOSE METABOLISM IN THE MITOPHAGY-MEDIATED MITOCHONDRIAL QUALITY CONTROL MECHANISM IN THE RENAL CORTEX DURING THE NORMOALBUMINURIC STAGE OF DIABETES MELLITUS

Naokazu Sato, Hakumei Chin, Hiroyuki Takahashi, Yoshifumi Kurosaki et autres

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A-054 Autolysosome formation involves a quality control mechanism of mitochondria and lysosomes in the renal cortex during the normoalbuminuric stage of diabetes mellitus

Naohito Ishii, Pamela K. Carmines, Naokazu Sato, Hiroyuki Takahashi et autres

Abstract Background Oxidative stress during the normoalbuminuric stage of type 1 diabetes mellitus (DM) damages renal cortical mitochondria, which subsequently are degraded by mitochondria-selective autophagy (mitophagy) involving lysosomes. Any lysosomes damaged in DM are degraded by lysosome-selective autophagy (lysophagy) to allow mitophagy …

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Oxidative Stress-Related Mitochondrial and Lysosomal Quality Control Mechanisms in Renal Cortex During the Normoalbuminuric Stage of Diabetes Mellitus

Naohito Ishii, Pamela K. Carmines, Naokazu Sato, Yoshifumi Kurosaki et autres

Background: Oxidative stress during the normoalbuminuric stage of type 1 diabetes mellitus (DM) damages renal cortical mitochondria. Subsequent mitochondrial autophagy (mitophagy) produces autophagosomes destined for lysosomal degradation; hence, any lysosomes damaged in DM must be either repaired or degraded and removed in …

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Sniff and reverse-sniff nasal respiratory pressures after exacerbation of chronic obstructive pulmonary disease: A single-center prospective study

Tsuyoshi Ichikawa, Sakurako Tajiri, Masanori Yokoba, Yu Horimizu et autres

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The Glasgow Prognostic Score Predicts Survival in Patients with Advanced Non-Small Cell Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations Who Are Treated with Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors

Yuki Akazawa, Satoshi Igawa, Kaori Yamada, Hiroki Yamamoto et autres

INTRODUCTION: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) with sensitive EGFR mutations. The Glasgow prognostic score (GPS) is an inflammation-assessing score based on C-reactive protein and albumin concentrations. Information …

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The Glasgow prognostic score predicts survival in patients with advanced non-small cell lung cancer harboring sensitive EGFR mutations who are treated with tyrosine kinase inhibitors

Yuki Akazawa, Satoshi Igawa, Kaori Yamada, Hiroki Yamamoto et autres

Abstract Background: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) with sensitive EGFR mutations. The Glasgow prognostic score (GPS) is an inflammation-assessing score based on C-reactive protein and albumin concentrations. …

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Mitochondrial Quality Control Mechanisms and Fatty Acid Metabolism in Renal Cortex During the Normoalbuminuric Stage of Diabetes Mellitus

Naohito Ishii, Pamela K. Carmines, Yoshifumi Kurosaki, Akemi Imoto et autres

Background: Oxidative stress during the normoalbuminuric stage of type 1 diabetes mellitus (DM) damages renal cortical mitochondria; hence, we aimed to determine if oxidative stress in DM triggers 1) mitochondrial fission or fusion, 2) mitophagy, and/or 3) increased fatty acid (FA) metabolism. …

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The Glasgow Prognostic Score Predicts Outcomes of Pembrolizumab or Atezolizumab Monotherapy in Patients with Pretreated Non-Small Cell Lung Cancer

Masashi Kasajima, Satoshi Igawa, Hiroya Manaka, Kaori Yamada et autres

INTRODUCTION: Predictors of the effectiveness of immune checkpoint inhibitor (ICI) monotherapy in previously treated patients with non-small cell lung cancer (NSCLC) remain ill-defined. We investigated whether the Glasgow prognostic score (GPS) could serve as such predictors. METHODS: Eighty patients treated with pembrolizumab …

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Recovery of respiratory muscle strength, physical function, and dyspnoea after lobectomy in lung cancer patients undergoing pulmonary rehabilitation: A retrospective study

Tsuyoshi Ichikawa, Masanori Yokoba, Yu Horimizu, Saki Yamaguchi et autres

OBJECTIVE: To characterise changes in respiratory muscle strength, physical function, and dyspnoea in patients who underwent pre- and post-operative exercise intervention following lobectomy for non-small-cell lung cancer (NSCLC). METHODS: This retrospective study included NSCLC patients who underwent lobectomy via video-assisted thoracoscopic surgery …

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MO455: Fatty Acid-Associated Albumin Induces Proliferation and Senescence of Proximal Tubular Cells

Yoshifumi Kurosaki, Rikke Nielsen, Motoshi Ouchi, Asuka Morita et autres

Abstract BACKGROUND AND AIMS Proteinuria is a major risk factor for the progression of chronic kidney disease. Protein overload in the proximal tubular epithelial cells causes oxidative stress, lysosomal dysfunction, inflammation and apoptosis, resulting in proximal tubule dysfunction. Recent studies have focussed …

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In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells

Yoshifumi Kurosaki, Akemi Imoto, Fumitaka Kawakami, Motoshi Ouchi et autres

Bardoxolone methyl [methyl-2-cyano-3, 12-dioxooleana-1, 9(11)dien-28-oate (CDDO-Me)], an activator of the nuclear factor erythroid-derived 2-related factor2 pathway, is a potential therapeutic candidate for the treatment of kidney diseases. However, its effect against cellular senescence remains unclear. This study aimed to investigate whether CDDO-Me …

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A Prospective Observational Study of Osimertinib for Chemo-Naive Elderly Patients with EGFR Mutation-Positive Non-Small Cell Lung Cancer

Satoshi Igawa, Masashi Kasajima, Taihei Ono, Takahiro Ozawa et autres

Background: The clinical outcomes of elderly patients with EGFR -mutated non-small cell lung cancer (NSCLC) who are treated with osimertinib have not been sufficiently evaluated. This study aimed to assess the efficacy and safety of osimertinib in elderly chemotherapy-naive patients with NSCLC …

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