Jianjiang Xu

Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Chuyue Yu, Xichen Wan, Jinsong Wei, Zhaoting Xu et autres

Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of the ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages …

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Cenegermin for the Treatment of Moderate or Severe Neurotrophic Keratopathy: Results from a Prospective, Phase IV, Open-Label Study in China

Su‐Xia Li, Jianjiang Xu, Zhiqiang Pan, Giacomo Siri et autres

INTRODUCTION: Neurotrophic keratopathy (NK) is a rare degenerative disease that can lead to epithelial breakdown, corneal ulceration, and potentially perforation and vision loss. Cenegermin is a recombinant human nerve growth factor approved for stage 2/3 NK, though data on its efficacy outside …

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Demographic Characteristics, Contributing Risk Factors, and Prognosis of Acanthamoeba Keratitis in Eastern China: An in vivo Confocal Microscopy-Based Fifteen-Year Study

Chuwei Lu, Jiajia Wang, Jiaxu Hong, Jianjiang Xu et autres

Purpose: keratitis (AK) in Eastern China in the recent 15 years using in vivo confocal microscopy (IVCM). Patients and Methods: This single-center, retrospective study included 145 patients (147 eyes) diagnosed with AK based on IVCM findings at the Eye & ENT Hospital …

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[The standardization of the diagnosis and treatment of infectious corneal epitheliopathy].

Jianjiang Xu, Qihua Le

confocal microscopy, and molecular diagnostics (tear virus antibodies, metagenomic sequencing). The tripartite evidence chain of "history-imaging-pathogen" is proposed to transcend morphology-dependent empiricism, with strict caution against glucocorticoid use before etiological confirmation. Standardized precision diagnosis at the epithelial stage is pivotal for early …

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Identification of novel biomarkers and associated immunoregulatory network in pterygium through integrated transcriptome analysis and machine learning approaches

Ning Lyu, Jun Xiang, Jiawen Wu, Yidan Fan et autres

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Corneal Topography Parameters and Tear Film Break-up Characteristics in Keratoconus Patients

Dan Wu, Jiaxu Hong, Suqian Wu, Jianjiang Xu

Aims/Background Previous studies have found that keratoconus (KC) patients are highly susceptible to dry eye disease (DED); however, the specific relationship between KC and DED has not been thoroughly investigated. This study aims to investigate the corneal topography parameters and tear film …

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The effectiveness of mindful walking based on the timing it right framework in patients with atrial fibrillation and chronic heart failure

Qin Lu, Jingjing Lu, Yeping Zheng, Xia Zhao et autres

Objective To explore the effects of mindful walking (MFW) based on the Timing It Right (TIR) framework on anxiety, depression, and cardiopulmonary function in patients with atrial fibrillation combined with chronic heart failure. Methods A total of 86 patients with atrial fibrillation …

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Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Chuyue Yu, Xichen Wan, Jinsong Wei, Xingru Wu et autres

Abstract Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages …

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Efficacy and Safety of Shexiang Tongxin Dropping Pill in Angina Patients with Coronary Slow Flow Phenomenon: A Multi-center, Randomized, Double-blind, Placebo-controlled Phase IV Trial

Na Li, Zhiqing He, Yasha Chen, Liansheng Wang et autres

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Efficacy and safety of Shexiang Baoxin Pill in patients with angina and non-obstructive coronary arteries: A multicenter, randomized, double-blind, placebo-controlled, phase Ⅳ clinical trial

Zhiqing He, Na Li, Xianhao Meng, Jingping Wang et autres

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Prospective evaluation of iris-trabecular contact using anterior segment optical coherence tomography and early intraocular pressure changes in eyes following penetrating keratoplasty

Yue Li, Yujin Zhao, Jiaxu Hong, Jianjiang Xu

BACKGROUND: To explore the changes of iris-trabecular contact (ITC) and intraocular pressure (IOP) in patients who underwent penetrating keratoplasty (PK) during early postoperative period. METHODS: This prospective study finally included 46 eyes of 46 patients who underwent PK or triple surgery. Slit …

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Application of Peplau's interpersonal relationship theory combined with case management in rehabilitation of patients after primary percutaneous coronary intervention

Lu Qin, Zhenliang Chu, Yeping Zheng, Jingjing Lu et autres

Objective To explore the effect of Peplau's interpersonal relationship theory (PIRT) combined with case management (CM) on exercise-based cardiac rehabilitation (EBCR), self-efficacy of rehabilitation and risk factors in patients after primary percutaneous coronary intervention (PCI). Methods The convenience sampling method was used …

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