Qihua Le

Mucoadhesive recombinant human catalase for dry eye disease: From protein engineering to first-in-human study

Ming Shao, Yiteng Lu, Wenjie Xie, Annan Lu et autres

cn (code pays fourni par la source)

Morphological alterations of corneal nerve after short-term scleral lens therapy for severe dry eye: an in vivo confocal microscopic study

Xiaohan Chen, Chuwei Lu, Xueyi Zhou, Xueyi Zhou et autres

cn (code pays fourni par la source)

Three-dimensional assessment of posterior polymorphous corneal dystrophy with swept-source optical coherence tomography

Jini Qiu, Lijia Tian, Yuhong Chen, Qihua Le et autres

Background: Posterior polymorphous corneal dystrophy (PPCD), also known as Schlichting dystrophy, can present as either autosomal dominant or isolated unilateral cases, with a similar phenotype but without a hereditary pattern. This study aimed to investigate the characteristics of PPCD using wide-field, high-resolution, …

cn (code pays fourni par la source)

In Vivo Biomarkers Of Limbal Stem Cell Deficiency

Qihua Le, Sophie X. Deng, Clémence Bonnet

us, fr (code pays fourni par la source)

Dual-action oral platform for integrated systemic and gut-targeted treatment of acute kidney injury

Jing-Yu Yeh, Cam-Hoa Mac, Po-Hsi Lin, Linh Dieu Nguyen et autres

tw, vn (code pays fourni par la source)

Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease

Yiteng Lu, Xichen Wan, Han Ye, Yuqing Wu et autres

Purpose: To investigate the pathogenetic role of sphingomyelin synthase 2 (SMS2) in dry eye disease (DED). Methods: Human corneal epithelial cells (HCECs) were exposed to oxidative stress (H₂O₂), hyperosmolarity, or inflammatory stimuli to evaluate SMS2 expression. SMS2 was silenced via small interfering …

cn (code pays fourni par la source)

Identification of a blink frequency threshold for maintaining tear film stability in young adults with dry eye symptoms

Yu Chai, Mingrui Cheng, Xinhua Liu, Yiteng Lu et autres

To determine the critical blink frequency threshold for maintaining tear film stability in young participants with dry eye symptoms. In this two-phase study, 45 young participants (aged 19-28 years) with dry eye symptoms (Ocular Surface Disease Index, OSDI ≥ 13) underwent spontaneous …

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Dynamic ocular surface secretome analysis in keratoconus patients under scleral lens intervention

Lang Zeng, Chien‐Min Lu, Xueyi Zhou, Zhi Chen et autres

To characterize the temporal dynamics of the ocular surface secretome in response to scleral lens (SL) wear in keratoconus and to explore potential molecular mechanisms. Ocular surface secretions were collected from four patients with keratoconus at baseline, 1 hour, and 1 month …

cn (code pays fourni par la source)

Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Chuyue Yu, Xichen Wan, Jinsong Wei, Zhaoting Xu et autres

Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of the ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages …

cn, th (code pays fourni par la source)

Demographics, Prevalence, and Characteristics of Limbal Stem Cell Deficiency in Southern California

Clémence Bonnet, Qihua Le, Daniel Cordova, Sheyla González et autres

PURPOSE: To report the prevalence, incidence, demographic characteristics, and clinical presentation of limbal stem cell deficiency (LSCD). METHODS: Retrospective review of medical records of patients with a diagnosis of LSCD at tertiary eye hospitals affiliated with the University of California, Los Angeles …

us (code pays fourni par la source)

Proteomic analysis of tear fluid: Comparative short-term effects of scleral lenses and rigid corneal lenses wear in ametropic healthy adults

Zhe Zhang, Li Zeng, Qihua Le, Yu Yu et autres

cn (code pays fourni par la source)

Demographic Characteristics, Contributing Risk Factors, and Prognosis of Acanthamoeba Keratitis in Eastern China: An in vivo Confocal Microscopy-Based Fifteen-Year Study

Chuwei Lu, Jiajia Wang, Jiaxu Hong, Jianjiang Xu et autres

Purpose: keratitis (AK) in Eastern China in the recent 15 years using in vivo confocal microscopy (IVCM). Patients and Methods: This single-center, retrospective study included 145 patients (147 eyes) diagnosed with AK based on IVCM findings at the Eye & ENT Hospital …

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