Hui Shan

Artificial intelligence-assisted proteomic signatures for discriminating malignant from benign pulmonary nodules

Juan Luo, Qiongye Dong, Jianyi Yang, Hui Shan et autres

Lung cancer remains a major global health burden. Although low-dose CT (LDCT) is effective for early detection, its clinical application is limited by a high false-positive rate and the need for subsequent invasive confirmation, such as biopsy. Meanwhile, the extensive protein-level alterations …

cn (code pays fourni par la source)

Deep Plasma Proteomics-Based Diagnostic Panel for Early Detection of Amnestic Mild Cognitive Impairment

Hui Shan, Gaigai Lu, Yuyao Yuan, Qiongye Dong et autres

Amnestic mild cognitive impairment (aMCI) is often considered an early clinical stage of Alzheimer's disease (AD), but its subtle presentation leads to infrequent neurological evaluations. Early plasma biomarker screening during routine check-ups in community hospitals could enhance aMCI detection rates. Advances in …

cn (code pays fourni par la source)

A nano-bio-coordination dynamic hydrogel with photothermal effects and osteogenic activity for the treatment of osteosarcoma

Fan Wu, Weiling Yin, Hui Shan, Jie Cang et autres

• A coordination hydrogel based biomacromolecules (osteogenic peptide and gelatin) and nanomaterials (CuS 2 nanoparticles) was fabricated. • The dynamic hydrogel exhibited injectability, self-healing, biocompatibility, and a controlled degradation rate. • The CuS 2 nanoparticles exhibit photothermal effects that could effectively ablate …

cn (code pays fourni par la source)

Elucidating the Role of Intralayer Cation Ordering and Disordering in Li 0.6 [Li 0.2 Mn 0.8 ]O 2 Cathode Materials

Huaifang Shang, Qiaojian He, Lina Yan, E Xiaoye et autres

ABSTRACT Full‐manganese (Mn) Li‐rich materials have gained attention owing to the limited availability of cobalt‐ or nickel‐based cathodes commonly used in batteries, which greatly restricts their potential for large‐scale application. However, their practical implementation is hindered by the rapid voltage/capacity decay during …

Rwanda, cn (code pays fourni par la source)

Overview of small proteins encoded by bacterial dual-function small RNAs

Xia Cai, Hui Shan, Jiaojiao Wang, Jiaxin Qin et autres

Small RNAs (sRNAs) are widely used by bacteria to regulate diverse biological processes. Although they are generally considered "non-coding", some sRNAs (called dual-function sRNAs) have been found to encode small proteins, which are usually less than 50 amino acids in length and …

cn (code pays fourni par la source)

Plasma lipidomic analysis reveals disruption of ether phosphatidylcholine biosynthesis and facilitates early detection of hepatitis B-related hepatocellular carcinoma

Yuyao Yuan, Di Yin, Di Liu, Hui Shan et autres

BACKGROUND: Hepatocellular carcinoma (HCC) is the third deadliest malignant tumor worldwide. Most patients are initially diagnosed as HCC at advanced stages and are too late for radical treatment by surgery, resulting in poor prognosis. Over 50% of the HCC patients are caused …

cn (code pays fourni par la source)

DNA polymerase switch-mediated CRISPR/Cas system for photoelectrochemical detection of apurinic/apyrimidinic endonuclease 1

Xinmiao Feng, Na Zhu, Qingao We, Meitian Wang et autres

cn (code pays fourni par la source)

Identification of a cancer stem cell-like subpopulation that promotes HCC metastasis

Chunyuan Yang, Yang Li, Zhao-Hai Wang, Hui Shan et autres

Background & Aims: Cancer stem cells (CSCs) are well-established drivers of tumorigenesis, but their role in regulating tumor metastasis remains poorly understood. Here, we report the identification and characterization of a cluster of metastasis-promoting CSC-like cells in hepatocellular carcinoma (HCC). Methods: CSC-like …

cn (code pays fourni par la source)

A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22

Weize Wang, Ling Liang, Zonglin Dai, Peng Zuo et autres

Abstract The CUL3-RING E3 ubiquitin ligases (CRL3s) play an essential role in response to extracellular nutrition and stress stimuli. The ubiquitin ligase function of CRL3s is activated through dimerization. However, how and why such a dimeric assembly is required for its ligase …

cn (code pays fourni par la source)

Platelet-Rich Plasma in Young and Elderly Humans Exhibits a Different Proteomic Profile

Zhitong Jiang, Can Huang, Erliang Guo, Xiangbin Zhu et autres

As people age, their ability to resist injury and repair damage decreases significantly. Platelet-rich plasma (PRP) has demonstrated diverse therapeutic effects on tissue repair. However, the inconsistency of patient outcomes poses a challenge to the practical application of PRP in clinical practice. …

cn (code pays fourni par la source)

Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis

Shu Ge, Wenjin Chen, Chenchen Huang, Hui Shan et autres

Background: P7C3 is a novel compound that has been widely applied in neurodegenerative diseases and nerve injury repair.Here, we show that higher concentrations of P7C3 than are required for in vivo neuroprotection have the novel function of suppressing renal cell carcinoma (RCC) …

cn (code pays fourni par la source)

Design of Hierarchical Nickel-Cobalt Phosphide/Nickel Oxide with Tunable Electronic Structure and Strong Chemical Interface for Advanced Supercapacitors

Gaini Zhang, Jingqian Liu, Hui Shan, Zheng-Dong Ma et autres

The design of a reasonable heterostructure electrode to achieve enhanced areal performance for supercapacitors remains a great challenge. Here, we constructed hierarchical porous NiCoP/NiO nanocomposites anchored on Ni foam with tunable electronic and structural properties, as well as robust interfacial interaction. In …

cn (code pays fourni par la source)