Ling Liang

Corrigendum to “Magnetic nanoparticles amplification-based terahertz and fluorescence dual-mode assays for efficient isolation and sensitive detection of circulating tumor cells” [Talanta 298 (2026) 128894]

Yi Zhou, Mei Xin, Ling Liang, Fengxin Xie et autres

cn (code pays fourni par la source)

A regulatory adaptor for RAD51’s AAA+ unfoldase promotes homologous recombination–mediated DNA repair and genome stability

Tao Zhou, Ming Pang, Xinxin Liang, Zenan Zhou et autres

DNA double-strand breaks, including those arising from DNA interstrand crosslinks, are highly cytotoxic forms of DNA damage. Their precise repair by homologous recombination (HR) is essential for maintaining genomic stability. During HR, timely disassembly of the core machinery, RAD51 nucleoprotein filaments, is …

cn, jp (code pays fourni par la source)

Hippocampal neuronal progranulin mediates estrogen‑deficiency‑induced affective vulnerability and lysosomal-autophagic dysfunction

Ni Lin, Ting-Hui Chen, Si-qi Jia, Qifan Yang et autres

Perimenopausal women typically face a heightened risk of emotional disturbances, including anxiety and depression. The estrogen decline increases vulnerability to mood disorders, but the molecular mechanisms underlying stress resilience remain unclear. Here, we identify hippocampal neuronal progranulin (PGRN), a secreted neuroprotective glycoprotein, …

cn, me (code pays fourni par la source)

Author Correction: Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover

Chuanda Zhu, Lu Qin, Zonglin Dai, Peng Zuo et autres

Following publication, some text has been updated for clarity. In the abstract, “Our structures reveal that midnolin binds to the proteasome via the RPN1 subunit by its C-terminal helix, and its ubiquitin-like domain interacts with the RPN11 deubiquitinase in a non-catalytic role” …

cn (code pays fourni par la source)

Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover

Chuanda Zhu, Lu Qin, Zonglin Dai, Peng Zuo et autres

The 26S proteasome typically degrades proteins marked by ubiquitin chains. However, a distinct, ubiquitin-independent degradation pathway for nuclear proteins exists, mediated by the adaptor protein midnolin, yet its molecular mechanism remains poorly understood. Here, we present nine cryo-electron microscopy structures of the …

cn (code pays fourni par la source)

ECSCR functions as a potential tumor suppressor in breast cancer cells

Sen Lian, Yi Huang, Ling Liang, Yiping Yang et autres

Breast cancer is the most commonly diagnosed malignancy among women worldwide. Triple-negative breast cancer (TNBC), a particularly aggressive subtype, is unresponsive to endocrine and targeted therapies. It is characterized by high rates of invasion and recurrence, a poor prognosis, and limited treatment …

cn (code pays fourni par la source)

Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation

Nan Zhao, Xiandong Zhou, Zhiwei Li, Ling Liang et autres

cn (code pays fourni par la source)

Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk

Ling Liang, Xin Nie, Nan Zhao, Menggeng Li et autres

Background Solar ultraviolet A (UVA) induces skin photodamage primarily by triggering endoplasmic reticulum (ER) stress, leading to misfolded protein accumulation and apoptosis. Coreopsis tinctoria Nutt. [Asteraceae] (CT), a medicinal chrysanthemum with antioxidant properties, has potential protective effects against UVA-induced skin injury. This …

cn, hk (code pays fourni par la source)

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

Fang Zhou, Robert J. Ju, Chenlu Kang, Jiayi Li et autres

Cells in highly crowded environments are exposed to fluctuating mechanical forces. While cells can activate the cortical migration machinery to escape from undesirable compressive stress, the consequence to less motile cells and of prolonged extensive confinement is yet to be uncovered. Here, …

cn, au, us (code pays fourni par la source)

Learn from nature: Biomimetic nanocarriers for intracellular protein delivery

Chuanda Zhu, Yicheng Pu, Ling Liang

Nanocarriers have been regarded as the most potential therapeutic weapons to combat tumors and genetic diseases using protein drugs. However, nanocarriers often face many challenges during the delivery process. Due to the existence of cell membrane barriers, nanocarriers may be restricted extracellularly …

cn (code pays fourni par la source)

Magnetic nanoparticles amplification-based terahertz and fluorescence dual-mode assays for efficient isolation and sensitive detection of circulating tumor cells

Yi Zhou, Mei Xin, Ling Liang, Fengxin Xie et autres

Sensitive, specific and accurate detection of circulating tumor cells (CTCs) is critical for early cancer diagnosis and prognosis evaluation. Here, we developed an innovative dual-mode sensing platform that integrates terahertz (THz) and fluorescence (FL) technologies for the accurate quantification of CTCs. This …

cn (code pays fourni par la source)

Correction to “Subcutaneous Implantable Microneedle System for the Treatment of Alzheimer’s Disease by Delivering Donepezil”

Ze Qiang Zhao, Ling Liang, Liu Fu Hu, Yu Ting He et autres