Platelet-Rich Plasma in Young and Elderly Humans Exhibits a Different Proteomic Profile
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Le résumé fourni par la source
As people age, their ability to resist injury and repair damage decreases significantly. Platelet-rich plasma (PRP) has demonstrated diverse therapeutic effects on tissue repair. However, the inconsistency of patient outcomes poses a challenge to the practical application of PRP in clinical practice. Furthermore, a comprehensive understanding of the specific impact of aging on PRP requires a systematic investigation. We derived PRP from 6 young volunteers and 6 elderly volunteers, respectively. Subsequently, 95% of high-abundance proteins were removed, followed by mass spectrometry analysis. Data are available via ProteomeXchange with the identifier PXD050061. We detected a total of 739 proteins and selected 311 proteins that showed significant differences, including 76 upregulated proteins in the young group and 235 upregulated proteins in the elderly group. Functional annotation and enrichment analysis unveiled upregulation of proteins associated with cell apoptosis, angiogenesis, and complement and coagulation cascades in the elderly. Conversely, IGF1 was found to be upregulated in the young group, potentially serving as the central source of enhanced cell proliferation ability. Our investigation not only provides insights into standardizing PRP preparation but also offers novel strategies for augmenting the functionality of aging cells or tissues.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Platelet-Rich Plasma in Young and Elderly Humans Exhibits a Different Proteomic Profile
- Date Crossref
- 15/04/2024
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Peking University Shenzhen Hospital Department of Cardiovascular Surgery pays non établi dans la noticeÉtablissement de santé
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University of Hong Kong - Shenzhen Hospital pays non établi dans la noticeÉtablissement de santé
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Harbin Medical University Department of Thoracic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Harbin Medical University pays non établi dans la noticeÉtablissement de santé
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Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center Department of Cardiovascular Surgery pays non établi dans la noticeUniversité ou école supérieure
Department of Cardiovascular Surgery — Peking University Shenzhen Hospital, University of Hong Kong - Shenzhen Hospital et Department of Thoracic Surgery — Harbin Medical University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.