Benoît Paquette

Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer

Benoît Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher et autres

The relapse rate for early-stage triple-negative breast cancer (TNBC) is significantly higher than that of other breast cancer subtypes. To reduce the relapse rate, we evaluated the relevance of targeting Rab4A to inhibit the increase in cancer cell invasion induced by radiotherapy …

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Employing a Combination of Chemoattractants to Trap Glioblastoma Cells in a Macroporous Hydrogel

Sahar Naasri, Hélène Therriault, Lisa Delattre, Nick Virgilio et autres

Background: A new paradigm for treating glioblastoma multiforme (GBM) cells was proposed. Instead of trying to eliminate cancer cells infiltrated in the brain, this new treatment is based on attracting them into a macroporous gel-based trap, where they are retained and then …

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Development of metastases in mice induced by plasma sample collected during radiotherapy in patient with triple-negative breast cancer: Role of Rab4A

Benoît Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher et autres

ABSTRACT The relapse rate in early-stage triple-negative breast cancer (TNBC) is significantly higher than in other breast cancer subtypes. This study assessed the relevance to target RAB4A to prevent the development of metastases that occur after treatment. The ability of cancer cells …

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Thermally sensitive and tunable water-soluble polymer molds for the preparation of porous hydrogels

Lisa Delattre, Arthur Lassus, Grégory De Crescenzo, Nathalie Faucheux et autres

ABSTRACT Porous hydrogels are highly sought-after biomaterials for regenerative medicine and 3D cell culture media. For such purposes, direct contact between the hydrogels and organic solvents during the synthesis step must be avoided as much as possible. In this work, porous water-soluble …

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Thermally Sensitive and Tunable Water-Soluble Polymer Molds for the Preparation of Porous Hydrogels

Lisa Delattre, Arthur Lassus, Grégory De Crescenzo, Nathalie Faucheux et autres

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CXCL12 impact on glioblastoma cells behaviors under dynamic culture conditions: Insights for developing new therapeutic approaches

Wiam El Kheir, Sahar Naasri, Bernard Marcos, Nick Virgilio et autres

Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor, with an average survival time of 14 to 20 months. Its capacity to invade brain parenchyma leads to the failure of conventional treatments and subsequent tumor recurrence. Recent studies have explored new …

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Combination of radiotherapy and immunotherapy in duality with the protumoral action of radiation

Benoît Paquette, Ayman Oweida

Radiotherapy is widely used to treat various cancers. Its combination with immune checkpoint inhibitors is intensively studied preclinically and clinically. Although the first results were very encouraging, the number of patients who respond positively remains low, and the therapeutic benefit is often …

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The role of pore size and mechanical properties on the accumulation, retention and distribution of F98 glioblastoma cells in macroporous hydrogels

Lisa Delattre, Sahar Naasri, Angéla Giraldo Solano, Hélène Therriault et autres

Glioblastoma (GBM) accounts for half of all central nervous system tumors. Once the tumor is removed, many GBM cells remain present near the surgical cavity and infiltrate the brain up to a distance of 20-30 mm, resulting in recurrence a few months …

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Macroporous chitosan/alginate hydrogels crosslinked with genipin accumulate and retain glioblastoma cancer cells

Lauriane Parès, Sahar Naasri, Lisa Delattre, Hélène Therriault et autres

Grade IV multiforme glioblastoma (GBM) is an aggressive cancer that remains incurable due to the GBM cells invading and proliferating in the surrounding healthy tissues, even after tumor resection. A new therapeutic paradigm to treat GBM is to attract and accumulate GBM …

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173 Plasma Collected During Radiotherapy in Triple-Negative Breast Cancer Patient Stimulates Development of Lung Metastases in a Mouse Model

Benoît Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher

175 Eliminate Cancer Cells Infiltrated in the Brain by Attracting Them Into a Macroporous Hydrogel Trap

Benoît Paquette, Caroline Safi, Sahar Naasri, Angéla Giraldo Solano et autres

Impact of simulated brain interstitial fluid flow on the chemokine CXCL12 release from an alginate-based hydrogel in a new 3D in vitro model

Wiam El Kheir, Anaïs Dumais, Bernard Marcos, Nick Virgilio et autres

Introduction: Extensive investigation has been undertaken regarding drug delivery systems for the management of glioblastoma multiforme (GBM). The infiltrative behavior of GBM cells within the brain tissue is primarily attributed to their heterogeneity, the movement of interstitial fluid (IFF), and the presence …

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