Accès ouvert
2026
article
OpenAlex
Oksana Sirenko, Astrid Michlmayr, Prathyushakrishna Macha, Sandra Grund‐Gröschke et autres
Attrition in the therapeutic pipeline can often be attributed to a lack of translational efficacy from pre-clinical to clinical phases. Organoids show great promise as a game-changer in disease modeling and drug screening, as they better resemble tissue structure and functionality, and …
gb
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Accès ouvert
2025
article
OpenAlex
Dominik Patrick Elmer, Georg Stockmaier, Sandra Grund‐Gröschke, Victoria Strobl et autres
BACKGROUND: Pharmacological targeting of Hedgehog (HH)/GLI has proven effective for certain blood, brain and skin cancers including basal cell carcinoma (BCC). However, limited response rates and the development of drug resistance call for improved anti-HH therapies that take synergistic crosstalk mechanisms and …
at, de
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Accès ouvert
2024
article
OpenAlex
Martin Wermke, Tobias A.W. Holderried, Jason J. Luke, Van Karlyle Morris et autres
Rationale of the trial Although the use of engineered T cells in cancer immunotherapy has greatly advanced the treatment of hematological malignancies, reaching meaningful clinical responses in the treatment of solid tumors is still challenging. We investigated the safety and tolerability of …
de, us
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Accès ouvert
2023
article
OpenAlex
Jan Pěnčík, Cécile Philippe, Michaela Schlederer, Emine Atas et autres
Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in mPCa. Here …
us, at, ch, cz, se, es, de, gb, it, fr
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2022
preprint
OpenAlex
Jan Pěnčík, Cécile Philippe, Michaela Schlederer, Matteo Pecoraro et autres
Abstract Prostate cancer (PCa) lethality is driven by its progression to a metastatic castration-resistant state, yet the signaling mechanisms underlying metastatic spread remain unknown. Here we show that STAT3 converges with the LKB1/mTORC1 and CREB to control metastatic disease in PCa mouse …
at, ch, us, cz, se, es, gb, de, it, fr
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Accès ouvert
2021
article
OpenAlex
Elisabeth Peer, Sophie Karoline Aichberger, Filip Vilotic, Wolfgang Gruber et autres
(1) Background: Aberrant activation of the hedgehog (HH)-GLI pathway in stem-like tumor-initiating cells (TIC) is a frequent oncogenic driver signal in various human malignancies. Remarkable efficacy of anti-HH therapeutics led to the approval of HH inhibitors targeting the key pathway effector smoothened …
at, de
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Accès ouvert
2021
preprint
OpenAlex
Elisabeth Peer, Sophie Karoline Aichberger, Filip Vilotic, Wolfgang Gruber et autres
Abstract (1) Background Aberrant activation of the Hedgehog (HH)/GLI pathway in stem-like tumor initiating cells (TIC) is a frequent oncogenic driver signal in various human malignancies. Remarkable efficacy of anti-HH therapeutics led to the approval of HH inhibitors targeting the key pathway …
at
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Sandra Grund‐Gröschke, Daniela Ortner, Antal Balázs Szenes-Nagy, Nadja Zaborsky et autres
Genetic activation of hedgehog/glioma-associated oncogene homolog (HH/GLI) signaling causes basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug …
at
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Accès ouvert
2020
article
OpenAlex
Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber et autres
Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential biomarkers for risk stratification, by utilizing a gene co-expression network of transcriptomics data in addition to laser-microdissected proteomics …
at, de, ch
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Accès ouvert
2019
article
OpenAlex
Sandra Grund‐Gröschke, Georg Stockmaier, Fritz Aberger
Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metastasis and metabolic rewiring. Several HH pathway inhibitors have already been approved for medical therapy of advanced and metastatic …
at
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Accès ouvert
2019
preprint
OpenAlex
Sandra Grund‐Gröschke, Daniela Ortner, Antal Balázs Szenes-Nagy, Nadja Zaborsky et autres
Abstract Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) proved an efficient medical therapy of BCC, although lack of durable responses and frequent …
at, sk
(code pays fourni par la source)