Accès ouvert
2026
article
OpenAlex
Mostafa M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham, Heba M. Amer et autres
Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key effector of the noncanonical inflammasome, has been shown to mediate an …
us, Égypte, it, Ouganda
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Accès ouvert
2026
preprint
OpenAlex
Owen D Whitham, Mostafa Eltobgy, Mohamed M. Shamseldin, Asmaa Badr et autres
Abstract Legionella pneumophila ( L. pneumophila ) is the causative agent of Legionnaires’ disease, a severe bacterial pneumonia. Difficulty in diagnosing Legionnaires’ disease leads to an underreporting of cases and delayed treatment. Rapid-acting, broad-spectrum therapies are needed to treat pathology while avoiding …
us, Égypte
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Mostafa M. Eltobgy, Mohamed Α. Shamseldin, Owen Whitham, Heba M. Amer et autres
Abstract Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired interferon responses, and defective T-cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key mediator of the non-canonical inflammasome, has been shown to mediate an …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mohamed Α. Shamseldin, Mostafa M. Eltobgy, Heba M. Amer, Owen Witham et autres
Abstract Description SARS-CoV2 devastated the world in 2019, with over 774 million cases and around 7 million deaths. Our lab has previously reported the role Caspase-4/11 plays in the innate immune response against SARS-CoV2, associating it with exacerbated lung pathology and immunothrombosis, …
us
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Accès ouvert
2025
article
OpenAlex
Jiayu Xu, Michelle Chamblee, Fei Jiang, Mahesh KC et autres
Negative-sense RNA viruses have been widely used as viral vectors for vaccine delivery. However, little is known about coronaviruses as vectors for delivering vaccines. Here, we have developed safe SARS-CoV-2 Omicron JN.1-based live attenuated vaccine candidates by combining a mutation (D130A) in …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Heba M. Amer, Mohamed M. Shamseldin, Sarah Faber, Mostafa M. Eltobgy et autres
Long COVID (LC) following SARS-CoV-2 infection affects millions of individuals world-wide and manifests with a variety of symptoms including cognitive dysfunction also known as "brain fog". This is characterized by difficulties in executive functions, planning, decision-making, working memory, impairments in complex attention, …
us
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Accès ouvert
2024
article
OpenAlex
Asmaa N. Badr, Kylene P. Daily, Mostafa M. Eltobgy, Shady Z. K. Estfanous et autres
Neuroinflammation and accumulation of Amyloid Beta (Aβ) accompanied by deterioration of special memory are hallmarks of Alzheimer's disease (AD). Effective preventative and treatment options for AD are still needed. Microglia in AD brains are characterized by elevated levels of microRNA-17 (miR-17), which …
us
(code pays fourni par la source)