Asmaa Badr

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

Mostafa Eltobgy, Mohamed Α. Shamseldin, Owen Whitham, Heba M. Amer et autres

Abstract Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired interferon responses, and defective T-cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key mediator of the non-canonical inflammasome, has been shown to mediate an …

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AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

Heba M. Amer, Mohamed M. Shamseldin, Sarah Faber, Mostafa Eltobgy et autres

Long COVID (LC) following SARS-CoV-2 infection affects millions of individuals world-wide and manifests with a variety of symptoms including cognitive dysfunction also known as "brain fog". This is characterized by difficulties in executive functions, planning, decision-making, working memory, impairments in complex attention, …

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Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease

Asmaa Badr, Kylene P. Daily, Mostafa Eltobgy, Shady Estfanous et autres

Neuroinflammation and accumulation of Amyloid Beta (Aβ) accompanied by deterioration of special memory are hallmarks of Alzheimer's disease (AD). Effective preventative and treatment options for AD are still needed. Microglia in AD brains are characterized by elevated levels of microRNA-17 (miR-17), which …

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Targeting microglia with mannose-coated nanoparticles to improve pathology and behavior in a mouse model of Alzheimer’s disease.

Asmaa Badr, Kylene P. Daily, Amal O. Amer

Abstract Neuroinflammation is a hallmark of Alzheimer’s disease (AD) pathobiology. Microglia in AD brains show elevated levels of microRNA-17 (miR-17), which maintains a balance between pro- and anti-inflammatory cytokine production. Microglia play an essential role in the production of cytokines; however, the …

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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous et autres

Abstract Alzheimer’s disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune …

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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer’s disease The Ohio State University College of Medicine

Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous et autres

Abstract Alzheimer’s Disease (AD) is the 6th leading cause of death in the US. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune …

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Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

Mostafa Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous et autres

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health concern, and new treatment strategies are needed. Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4) and its mouse …

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CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages

Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kaitlin Hamilton et autres

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore, the role of CFTR in maintaining the …

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Renal arterial resistive index as a noninvasive biomarker of disease activity in lupus nephritis patients

Mona H. Abd Elsamea, Asmaa Badr, Hamdy Ibrahim, Esraa A. Talaat

To evaluate the renal resistive index (RI) in lupus nephritis (LN) patients and to study its association with clinical features, laboratory investigations and LN pathological classes in systemic lupus erythematosus (SLE) patients. The study included 45 SLE patients and 25 matched controls. …

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Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases

Ashley E. Russell, Asmaa Badr, Ali Rai, Cierra Carafice et autres

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Evaluation of serum calprotectin level as a biomarker of disease activity in rheumatoid arthritis and osteoarthritis patients

Mona H. Abd Elsamea, Safaa Mahran, Asmaa Badr, Dalia Tarik Kamal et autres

To measure the levels of serum calprotectin (CLP) in rheumatoid arthritis (RA) and osteoarthritis (OA) patients and to assess its association with disease activity, severity and functional status. A total of 30 RA and30 OA patients and 30 controlswere included. Rheumatoid factor …

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Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

Mostafa Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous et autres

Abstract SARS-CoV-2 is a worldwide health concern, and new treatment strategies are needed 1 . Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4), and its mouse homologue, caspase-11 (CASP11), …

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