Till Reinhardt

Metronidazole and ether derivatives target Helicobacter pylori via simultaneous stress induction and inhibition

Michaela K. Fiedler, Marianne S. I. Pandler, Ruolan Gong, Sonja Fuchs et autres

Abstract Metronidazole is a front-line drug for the treatment of Helicobacter pylori infections. However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies are required to overcome resistance. Here we performed activity-based protein profiling with …

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Dual-targeting 5-nitroimidazole ethers eradicate H. pylori by induction of stress and disabling its adaptive response

Stephan A. Sieber, Michaela K. Fiedler, Ruolan Gong, Sonja Fuchs et autres

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Chemische Proteomik enthüllt menschliche Off‐Targets der durch Fluorchinolone induzierten mitochondrialen Toxizität

Till Reinhardt, Yassmine El Harraoui, Robin Alexander Rothemann, A. Jauch et autres

Abstract Fluorchinolone (FQs) sind eine wichtige Klasse potenter Breitbandantibiotika. Ihre allgemeine Verwendung wird jedoch zunehmend durch unerwünschte Nebenwirkungen eingeschränkt. Während allgemeine Mechanismen für die Fluorchinolon‐assoziierte Behinderung (FQAD) identifiziert wurden, sind die zugrundeliegenden molekularen Ziele der Toxizität nach wie vor schwer fassbar. In …

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Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Till Reinhardt, Yassmine El Harraoui, Robin Alexander Rothemann, A. Jauch et autres

Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …

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Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity

Till Reinhardt, Nina C. Bach, Robin Alexander Rothemann, A. Jauch et autres

Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …

de (code pays fourni par la source)

Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity

Till Reinhardt, Nina C. Bach, Robin Alexander Rothemann, A. Jauch et autres

Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …

de (code pays fourni par la source)

Indolin-2-one Nitroimidazole Antibiotics Exhibit an Unexpected Dual Mode of Action

Till Reinhardt, Kyu M. Lee, Lukas Niederegger, Corinna R. Hess et autres

High Resolution Image Download MS PowerPoint Slide Nitroimidazoles such as metronidazole are used as anti-infective drugs against anaerobic bacteria. Upon in vivo reduction of the nitro group, reactive radicals damage DNA and proteins in the absence of oxygen. Unexpectedly, a recent study …

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Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

Martina Meßner, Melanie M. Mandl, Mathias W. Hackl, Till Reinhardt et autres

The human mitochondrial ClpXP protease complex (HsClpXP) has recently attracted major attention as a target for novel anti-cancer therapies. Despite its important role in disease progression, the cellular role of HsClpXP is poorly characterized and only few small molecule inhibitors have been …

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Structure of mature activin A with small molecule 2

Joseph McLoughlin, P.B. Brear, Till Reinhardt, David R. Spring et autres

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion

Sarah L. Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton et autres

Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable multidirectional fragment growth, limiting the efficiency of the hit evolution process. Diversity-oriented synthesis …

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NDT of spot welds by imaging analysis of the residual magnetic flux density – Investigation on the influence of electrode indentation on the measurement results

Christian Mathiszik, Till Reinhardt, Jörg Zschetzsche, Uwe Füssel

Nondestructive testing (NDT) of spot welds still poses a great challenge for industrial mass production like automotive body manufacturing or rail vehicle constructions. In these production areas, ultrasonic-based NDT methods with pulse-echo technology have become established. Hitherto, these methods require a lot …

Synthesis of Double-Bond-Substituted Hemithioindigo Photoswitches

Aaron Gerwien, Till Reinhardt, Péter Mayer, Henry Dube

A very short, high yielding, and convergent synthesis with broad substrate scope, enabling access to a very diverse range of hemithioindigos with 4-fold substituted double-bonds, is presented. With this method, carbon as well as nitrogen, oxygen, or sulfur based substituents can easily …

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