Mei Zi Yang

Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis

Wenhua He, Ling Ding, Zhijun Liu, Ming’e Hua et autres

Importance: Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective: To examine whether low-molecular-weight heparin (LMWH) combined with insulin is superior to insulin alone in improving clinical …

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Efficacy and safety of indwelling double-pigtail stents after endoscopic necrosectomy in patients with necrotizing pancreatitis complicated with disconnected pancreatic duct syndrome: A follow-up study

Zhengang Zhou, Qian Liao, Jingwen Rao, Tianming Lai et autres

ABSTRACT Background and Objectives Disconnected pancreatic duct syndrome (DPDS) is a significant cause of pancreatic fluid collection (PFC) recurrence in patients with necrotizing pancreatitis (NP). Effective management strategies for DPDS are crucial to improve patient outcomes. This study aimed to evaluate the …

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Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling

Qishan Chen, Ya Yu, Qiaohang Zhao, Danqing Yu et autres

The global incidence of obesity-related metabolic disorders and their comorbidities continue to increase along with a demand for innovative therapeutic interventions. An in-depth understanding of de novo thermogenic adipogenesis is vital to harness the potential of these adipocytes. Here, we combine genetic …

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IDDF2025-ABS-0207 Therapeutic inhibition of pancreatic triglyceride lipase ameliorates hypertriglyceridemic pancreatitis in mice

Wenhua He, Jingwen Rao, Mei Zi Yang, Yin Zhu

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Novel roles of Nrf3–Trim5 axis in vascular smooth muscle cell dysfunctions and neointimal hyperplasia

Qishan Chen, Shasha Sun, Zhenning Shi, Leyu Wang et autres

AIMS: Neointimal hyperplasia (NIH) characterized by vascular smooth muscle cell (VSMC) dysfunctions plays a critical role in many vascular diseases including atherosclerosis and restenosis, which leads to serious ischaemic complications and has limited therapeutic approaches. Our previous studies confirm a critical role …

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Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2

Qishan Chen, Ancheng Zheng, Xiaolei Xu, Zhenning Shi et autres

BACKGROUND: Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in regulating redox signaling and tissue homeostasis. Here, we aimed to evaluate the role and mechanism …

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Esipuhe / Förord

Niina Hynninen, Irina Herneaho, Eeva Sippola, Johanna Isosävi et autres

Tieteellisten seurain valtuuskunta

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Perspectives on Language and Participation

Niina Hynninen, Irina Herneaho, Johanna Isosävi, Mei Zi Yang

Language plays a key role in enabling and restricting participation in society. Considering the increasing linguistic diversity in education, working life and society at large, it is important to understand what it requires from individuals to participate and for institutions to support …

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General evaluation model for complex environment system

Mei Zi Yang, Yong Xing Wang, Juan Wu, J. J. Song et autres

Establishing an effective evaluation model to analyze the actual environmental level of the multi-indicator systems is an urgent challenge. However, due to the complexity of the environmental system, the factors that determine the practical system are usually interrelated. To solve this problem, …

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BDNF levels in adipose tissue and hypothalamus were reduced in mice with MSG-induced obesity

Yong Jun Jin, Peng Cao, Wei Bian, Ming E. Li et autres

OBJECTIVES: To observe the expression of brain-derived neurotrophic factor (BDNF) in hypothalamic and adipose tissue in mice with monosodium glutamate (MSG)-induced obesity. METHODS: The effects of hypothalamic lesions, specifically arcuate nucleus (ARC) lesions, induced by MSG injection were studied in male ICR …

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Phage-display library biopanning and bioinformatic analysis yielded a high-affinity peptide to inflamed vascular endothelium both in vitro and in vivo

Min Yang, Chenwu Liu, Maochang Niu, Yonghe Hu et autres

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Simultaneous Determination of Glutamate, Glycine, and Alanine in Human Plasma Using Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate and High-Performance Liquid Chromatography

Qing Zhong Li, Qing Xian Huang, Shu Cui Li, Mei Zi Yang et autres

A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method has been validated for determining concentrations of glutamate, glycine, and alanine in human plasma. Proteins in plasma were precipitated with perchloric acid, followed by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). Simultaneous analysis of …

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