Hassan Hammoud

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot et autres

Homozygosity for rare loss-of-function IL23R variants abolishes IL-23-dependent IFN-γ production by lymphocytes, including NK and innate-like T cells, thereby underlying clinical disease due to weakly virulent mycobacterial species. We report selective enrichment in homozygosity for four hypomorphic IL23R variants in our cohort …

fr, us, gb, au, de, Maroc, pk, co, it, tr, ar, lb, es, be, ir, in, ie (code pays fourni par la source)

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Q. Philippot et autres

Abstract Homozygosity for rare loss-of-function IL23R variants abolishes IL-23–dependent IFN-γ production by lymphocytes, including NK and innate-like T cells, thereby underlying clinical disease due to weakly virulent mycobacterial species. We report selective enrichment in homozygosity for four hypomorphic IL23R variants in our …

fr, gb, us, au, de, Maroc, pk, co, it, tr, ar, lb, es, be, ir (code pays fourni par la source)

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Fahd A. Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada-Velez et autres

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is globally very rare, except for IFNAR1 and IFNAR2 deficiency in Western Polynesia …

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Fahd A. Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada‐Vélez et autres

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is globally very rare, except for IFNAR1 and IFNAR2 deficiency in Western Polynesia …

sa, us, au, fr, ca, br, tr, mx, lb, sg, ae, hk, il, th, be, gb (code pays fourni par la source)

Paths to improve voluntary blood donation in mixed public/private blood donation systems such as in Lebanon?

Tarek Bou Assi, Antoine B. Haddad, Nathalie Ghanem, Reve Chahine et autres

lb, fr (code pays fourni par la source)

Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia

Hassan Hammoud, Khadija Elhabazi, Raphäelle Quillet, Isabelle Bertin et autres

Neuropeptide FF receptors (NPFF1R and NPFF2R) and their endogenous ligand neuropeptide FF have been shown previously to display antiopioid properties and to play a critical role in the adverse effects associated with chronic administrations of opiates including the development of opioid-induced hyperalgesia …

fr (code pays fourni par la source)

Multimodal Clinical Pathway With Adductor Canal Block Decreases Hospital Length of Stay, Improves Pain Control, and Reduces Opioid Consumption in Total Knee Arthroplasty Patients: A Retrospective Review

Terry Allan Ellis, Hassan Hammoud, Philip Dela Merced, Nishankkumar Patel Nooli et autres

us (code pays fourni par la source)

Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels

Omar Alijevic, Hassan Hammoud, Anand Vaithia, Viktor Trendafilov et autres

Acid-sensing ion channels (ASICs) are neuronal Na + -selective ion channels that open in response to extracellular acidification. They are involved in pain, fear, learning, and neurodegeneration after ischemic stroke. 2-Guanidine-4-methylquinazoline (GMQ) was recently discovered as the first nonproton activator of ASIC3. …

ch, fr (code pays fourni par la source)

Cover Picture: Unusual O‐Bridged Symmetric Quinoline‐Based Ligand for the Formation of Luminescent Mono‐Aqua Lanthanide Complexes (ChemistrySelect 21/2016)

Hassan Hammoud, Ana de Bettencourt‐Dias, Martine Schmitt, Jorge H. S. K. Monteiro et autres

The cover picture shows the ultraviolet (UV) irradiation of a novel sophisticated chromophore-containing ligand chelated to luminescent trivalent lanthanide metal ion i.e., Europium(III) or Terbium(III). This ligand is based on two O-bridged quinolines bearing carboxylate moieties to reinforce both the coordination to …

fr, us (code pays fourni par la source)

ChemInform Abstract: Synthesis of Hydroxybenzofurans by Condensation of Quinones with Benzoylacetone: Revised Structure of the Adducts.

Hassan Hammoud, Qian Zhao, Laurent Désaubry

Abstract In contrast to a previous report the title transformation does not provide 3‐acyl‐5‐hydroxybenzofurans, but the 2‐methyl‐3‐benzoyl isomers of the latter.

fr (code pays fourni par la source)

Unusual O‐Bridged Symmetric Quinoline‐Based Ligand for the Formation of Luminescent Mono‐Aqua Lanthanide Complexes

Hassan Hammoud, Ana de Bettencourt‐Dias, Martine Schmitt, Jorge H. S. K. Monteiro et autres

Abstract A novel ligand based on a O‐bridged symmetrical bis‐quinoline containing carboxylate moieties has been synthesized and its coordination and sensitization ability for lanthanide ions has been studied in aqueous solution. The efficient 7‐step methodology developed starts from commercial 8‐methylquinoline. This new …

fr, us (code pays fourni par la source)

Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts

Hassan Hammoud, Qian Zhao, Laurent Désaubry

fr (code pays fourni par la source)