Omar Alijevic

Correction: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Mohamed Bilal Fares, Omar Alijevic, Stéphanie Johne, Cassia Overk et autres

Correction on: Error in figure/tableIn the published article, there was an error in Figure 3C as published whereby micro-repeats appeared in the panel corresponding to the hippocampus of the vehicle non-tg control image. The corrected Figure 3 and its caption appear below. …

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Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Mohamed Bilal Fares, Omar Alijevic, Stéphanie Johne, Cassia Overk et autres

Introduction Alpha-synuclein (α-Syn) aggregation, transmission, and contribution to neurotoxicity represent central mechanisms underlying Parkinson’s disease. The plant alkaloid “nicotine” was reported to attenuate α-Syn aggregation in different models, but its precise mode of action remains unclear. Methods In this study, we investigated …

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Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids

Omar Alijevic, Oihane Jaka, Ainhoa Alzualde, Diana Maradze et autres

Alkaloids that target nicotinic acetylcholine receptors (nAChR) are of great interest because of the critical role they play in mood and anxiety. However, understanding of the neuropharmacological effects of nicotinic alkaloids, such as cotinine and anatabine, is very limited. In this study, …

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Changes in H+, K+, and Ca2+ Concentrations, as Observed in Seizures, Induce Action Potential Signaling in Cortical Neurons by a Mechanism That Depends Partially on Acid-Sensing Ion Channels

Omar Alijevic, Zhong Peng, Stephan Beat Kellenberger

Acid-sensing ion channels (ASICs) are activated by extracellular acidification. Because ASIC currents are transient, these channels appear to be ideal sensors for detecting the onset of rapid pH changes. ASICs are involved in neuronal death after ischemic stroke, and in the sensation …

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Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish

Ainhoa Alzualde, Oihane Jaka, Diogo A. R. S. Latino, Omar Alijevic et autres

Alkaloids are a structurally complex group of natural products that have a diverse range of biological activities and significant therapeutic applications. In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine receptor (nAChR)-activating alkaloids with reported neuropharmacological effects but whose …

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Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures

Mehmet Kesımer, Matthew R. Redinbo, Ashley G. Henderson, Sompop Bencharit et autres

The epithelial sodium channel (ENaC) is responsible for Na+ and fluid absorption across colon, kidney, and airway epithelia. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is a secreted, innate defense protein and an autocrine inhibitor of ENaC that is highly …

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Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons

Omar Alijevic, Olivier Bignucolo, Echrak Hichri, Zhong Peng et autres

channels. They are involved in fear behavior, learning, neurodegeneration after ischemic stroke and in pain sensation. ASIC activation has so far been studied only with fast pH changes, although the pH changes associated with many roles of ASICs are slow. It is …

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Pharmacological Characterization of Natural Tobacco Alkaloids in the Presence of Positive Allosteric Modulators Against Human α4β2 and α7 Nicotinic Acetylcholine Receptors

Omar Alijevic, Damian Mc Hugh, Anatoly A. Mazurov, Julia Hoeng et autres

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Human α4β2 and α7 Nicotinic Acetylcholine Receptor Profiles of NS3861 Reveal Its Broad Activity in Functional Electrophysiology Assays

Damian Mc Hugh, Omar Alijevic, Julia Hoeng

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An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors

Omar Alijevic, Damian McHugh, Lucien Rufener, Anatoly A. Mazurov et autres

Nicotinic acetylcholine receptor (nAChR) subtype-selective pharmacological profiles of tobacco alkaloids are essential for understanding the physiological effects of tobacco products. In this study, automated electrophysiology was used to functionally characterize the effects of distinct groups of tobacco alkaloids on human α4β2 and …

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Analysis of ASIC1a function and signalling

Omar Alijevic, Olivier Bignucolo, Echrak Hichri, Zhong Peng et autres

The deposited files include the dataset of the experimental part of the submitted manuscript on the function of ASIC1a, as well as Matlab scripts of kinetic models that are part of the study.

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Analysis of ASIC1a function and signalling

Omar Alijevic, Olivier Bignucolo, Echrak Hichri, Zhong Peng et autres

The deposited files include the dataset of the experimental part of the submitted manuscript on the function of ASIC1a, as well as Matlab scripts of kinetic models that are part of the study.

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