Zehui He

A meta-analysis of single agent and dual immune checkpoint inhibitors in metastatic triple negative breast cancer

Phaedon D. Zavras, Hugo Lara-Martinez, Qi Nie, Ming Li et autres

Abstract Purpose : Single-agent programmed cell death-1 inhibitors or its ligand (PD-1/PD-L1i) demonstrate low response rates in metastatic triple-negative breast cancer (mTNBC), though a subset of patients may achieve durable responses. Data evaluating combined PD-1/PD-L1i and cytotoxic T-lymphocyte–associated protein 4 inhibition (CTLA-4i) …

us, ie, br (code pays fourni par la source)

Validation of prognostic scores in Hispanic patients with advanced solid tumors enrolled in a single-center phase I clinical trial program.

Darin Poei, Zehui He, Ming Li, Hadi Erfani et autres

1541 Background: Prognostic scores are commonly used to guide enrollment in early-phase oncology trials. Despite their widespread use, these models have not been specifically evaluated in Hispanic patients, to the best of our knowledge — a population historically underrepresented in clinical trials. …

us (code pays fourni par la source)

Motor skills influence social function through health-related fitness in children with autism: a cross-sectional study

Hui Shen, Zixuan Zou, Shuqi Jia, Qiang Wang et autres

Objective: To examine whether health-related physical fitness mediates the association between fundamental motor skills (FMS) and social functioning in school-age children with autism spectrum disorder (ASD). Methods: A total of 117 school-age children with ASD were recruited from special education schools. FMS …

cn, gb (code pays fourni par la source)

Effects of exercise interventions on core health outcomes in patients with SLE: systematic review and meta-analysis

Zehui He, Shuqi Jia, Mengsi Chen, Xinxin Shi et autres

OBJECTIVES: This meta-analysis evaluated the effects of exercise interventions on key health outcomes in adults with SLE, including fatigue, physical function, aerobic capacity, disease activity, depression and pain. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, …

cn, us (code pays fourni par la source)

PRAME boosts T-cell tumor immunity in specific HLA phenotypes and promotes breast cancer stemness via CCL18 chemokine signaling

Xuan Li, Yue Bi, Zehui He, P N Yu et autres

Background/objective Tumor-associated macrophages (TAMs) and chemokine CCL18 play a pivotal role in breast cancer (BC) metastasis. They also promote breast cancer stem cells (BCSCs) enrichment. The melanoma-associated antigen such as preferentially expressed antigen in Melanoma (PRAME) is abnormally expressed in many cancers …

cn (code pays fourni par la source)

Intermittent fasting (IF) during PD-1 checkpoint blockade: A pilot safety and feasibility study.

Ching Ying Lin, Fumito Ito, Adam Garsa, Andrew Lim et autres

e23008 Background: Dysregulated metabolism, including increased glycolysis and production of immunosuppressive metabolites, may contribute to immune escape. Metabolic reprogramming may thus present an opportunity to overcome T-cell dysfunction and improve outcomes. Recently clinical studies suggest intermittent fasting (IF) can enhance immune function, …

us (code pays fourni par la source)

Identifying physician perspectives of facilitators and barriers in clinical trial accrual to inform implementation strategies for advancing equitable enrollment in a large comprehensive cancer center.

Syma Iqbal, Emmeline Friedman, Vibha Kodancha, Zehui He et autres

e23030 Background: While robust infrastructure is established to support high quality clinical trials at USC Norris Comprehensive Cancer Center (NCCC), implementation strategies and maintenance of health equity goals remain critical to ensuring clinical trials align with catchment area communities. This study aims …

us (code pays fourni par la source)

Tu1201: PREVALENCE AND PROGRESSION OF GASTRIC CANCER PRECURSOR LESIONS THROUGH SERIAL ENDOSCOPIES IN A KOREAN AMERICAN POPULATION

Jennifer M.S. Koh, Erica Tran, J. Chun, Zehui He et autres

Abstract 3225: A meta-analysis of single agent versus combination immune checkpoint inhibitors in metastatic triple negative breast cancer

Phaedon D. Zavras, Hugo Lara-Martinez, Qi Nie, Julius Y. Kattoula et autres

Abstract Background: Immune checkpoint inhibitors (ICIs) are active against triple-negative breast cancer (TNBC), and approved in combination with chemotherapy, or as a single agent in patients with high tumor mutational burden and/or microsatellite instability/mismatch repair deficiency. A number of studies have been …

us, br (code pays fourni par la source)

Reproducibility Companion Paper:In-processing User Constrained Dominant Sets for User-Oriented Fairness in Recommender Systems

Yixiu Liu, Zehui He, Yuyuan Li, Zhongxuan Han et autres

In this paper, we reproduce experimental results presented in our earlier work titled "In-processing User Constrained Dominant Sets for User-Oriented Fairness in Recommender Systems" that was presented in the proceeding of the 31st ACM International Conference on Multimedia.This work aims to verify …

Performance of the EQ-5D-5L With Skin Irritation and Self-Confidence Bolt-On Items in Patients With Urticaria

Jun Feng, Nan Luo, Jie Guo, Dongmei Wang et autres

cn, sg, Ouganda (code pays fourni par la source)

Modulating metal-organic frameworks by surface engineering of stearic acid modification for follicular drug delivery and enhanced hair growth promotion

Zehui He, Zhenda Liu, Yongtai Zhang, Teng Guo et autres

Cyclodextrin metal-organic frameworks (CD-MOF) as delivery carriers have gained great attention in the biomedical field. However, limited by challenges of moisture-sensitive nature, the design and application of CD-MOF-based hair follicle delivery for androgenic alopecia (AGA) has rarely been explored. We developed the …

cn (code pays fourni par la source)