Xinxin Shi

Clinically Accessible Phenotypes Refine Cardiovascular Risk Stratification Beyond Contemporary Clinical Equations

Hongxi Yang, Ju Guo, Xinxin Shi, Kejia Ma et autres

BACKGROUND Contemporary cardiovascular risk equations guide prevention, yet cardiovascular risk remains distributed beyond the highest-risk groups. Whether broader baseline phenotyping can improve risk stratification and whether this information can be reduced to clinically accessible measures is uncertain. OBJECTIVES To assess whether baseline …

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Analysis of the biofidelity of aPLI under low-speed collision conditions

Xinxin Shi, Bin Ye, Yongcheng Long, Zhenfei Zhan et autres

To evaluate the applicability and limitations of the advanced pedestrian legform impactor (aPLI) under reduced-speed pedestrian lower-limb impact conditions. Finite element simulations were conducted to compare the kinematic and injury responses of the aPLI with two human body models, THUMS and GHBMC. …

Analysis of the biofidelity of aPLI under low-speed collision conditions

Xinxin Shi, Bin Ye, Yongcheng Long, Zhenfei Zhan et autres

To evaluate the applicability and limitations of the advanced pedestrian legform impactor (aPLI) under reduced-speed pedestrian lower-limb impact conditions. Finite element simulations were conducted to compare the kinematic and injury responses of the aPLI with two human body models, THUMS and GHBMC. …

Efficacy and safety of Lingbao Huxin Dan in the treatment of sick sinus syndrome: a randomized, single-blind, placebo-controlled, crossover trial

Yue Wu, Yucheng Wang, Xing Zhou, Zhijun Wang et autres

Background Permanent pacemaker implantation is the standard treatment for symptomatic sick sinus syndrome (SSS), but it does not reverse the underlying sinus node dysfunction. Lingbao Huxin Dan (LBHXD) may benefit patients with bradyarrhythmia. However, robust clinical evidence regarding its efficacy and safety …

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Differences in inpatient hypertension management practices between specialists and non-specialists in Zhejiang Province, China

Yue Wu, Cheng Tong, Yi-Xiang Wang, Dongming Lin et autres

Objective To investigate the differences in management practices for hospitalised hypertensive patients between cardiovascular specialists and non-specialists, identify key determinants affecting the quality of blood pressure (BP) control, and offer evidence-based recommendations to support the standardisation of hypertension management protocols. Methods A …

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Dynamic dose–time proteomic profiling of cadmium exposure in rat prefrontal cortex

Hu Z, Feng Han, HAO GAO, Sheng Wan et autres

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Effects of exercise interventions on core health outcomes in patients with SLE: systematic review and meta-analysis

Zehui He, Shuqi Jia, Mengsi Chen, Xinxin Shi et autres

OBJECTIVES: This meta-analysis evaluated the effects of exercise interventions on key health outcomes in adults with SLE, including fatigue, physical function, aerobic capacity, disease activity, depression and pain. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, …

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Signaling pathway of DNA replication and toll-like receptors was inhibited in C6/36 cells infected with Japanese encephalitis virus

Yan Ming Gao, Xinxin Shi, Bing Li, Ning Shi et autres

BACKGROUND: The Aedes albopictus C6/36 cell line is model system for studying mosquito-borne viruses. These cells exhibit high permissiveness to Japanese encephalitis virus (JEV), supporting robust viral replication and producing a significant viral load. METHODS: Given C6/36 cells established susceptibility, this study …

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TaPYR10 Coordinates Abscisic Acid Sensing and Downstream Gene Activation to Deliver Drought Resilience and Yield Benefits in Wheat

Yingjia Zhao, Jingting Zhang, Chengjin Guo, Yanyang Zhang et autres

Abscisic acid (ABA) receptors (PYR) are essential components of the ABA signalling pathway. This study reported wheat PYR gene, TaPYR10, in modulating plant adaptation to drought stress. TaPYR10 contains conserved PYR motifs and targeted nucleus. TaPYR10 transcripts were upregulated in response to …

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The MAPK regulatory module TaMPKKK18 ‐ 3B / TaMPKK1 .2‐ 6B / TaMPK2 ‐ 1D / TaNAC2 ‐ 5B regulates low‐P stress response in Triticum aestivum

Yanyang Zhang, Xiangqiang Li, Li Yan Guo, Xiaoxin Fu et autres

The mitogen-activated protein kinase (MAPK) signaling cascades play crucial roles in mediating abiotic stress responses. This study characterized TaMPKKK18-3B, a member of the MAPK kinase kinase family, in mediating low-P stress response in Triticum aestivum. TaMPKKK18-3B contains conserved motifs shared by MAPKKK …

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The impact of SULT1E1-mediated sleep characteristics on lung cancer risk: A mediation Mendelian randomization analysis study

Xinxin Shi, Hengheng Zhang, Yuanfang Xin, Yumei Guan et autres

The interplay between sleep characteristics, estrogen sulfotransferase (SULT1E1), and lung cancer may involve complex interactions. While prior research has predominantly examined the association of SULT1E1 with breast cancer and the individual effects of sleep characteristics on lung cancer, the potential multifaceted interactions …

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Evaluation of Efficacy and Safety of Immunotherapy in Unresectable Locally Advanced or Metastatic Gastric Cancer: A Network Meta-Analysis

Yumei Guan, Shuqin Cao, Xinxin Shi, Xinzhang Li et autres

Background: The therapeutic efficacy and safety profile of immune checkpoint inhibitors (ICIs) across various treatment phases for unresectable locally advanced or metastatic gastric cancer (GC) remain inadequately characterized. This investigation seeks to delineate optimal immunotherapy strategies through a comprehensive Network Meta-Analysis (NMA). …

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