Zheng Fang

PELSA-Decipher: A Software Tool for the Processing and Interpretation of Ligand–Protein Interaction Data Sets Acquired by PELSA

Haiyang Zhu, Keyun Wang, Kejia Li, Zheng Fang et autres

Understanding protein-ligand interactions is fundamental to life sciences, including the elucidation of drug action mechanisms and regulatory processes in cellular metabolism and signaling. Recently, a robust ligand modification-free method, termed peptide-centric local stability assay (PELSA), has been developed to identify the protein …

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Application and Evaluation of Indocyanine Green Fluorescence Imaging in Pediatric Testicular Torsion Surgery

Ting Zhang, Mingcui Fu, Xu Cao, Hongliang Xia et autres

Objectives To assess the feasibility of ICG-NIRF imaging technology in evaluating testicular blood supply during pediatric testicular torsion surgery and guiding intraoperative surgical decision-making. Methods A retrospective study was performed on patients diagnosed with testicular torsion and treated surgically at our hospital …

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Theoretical study of XUV pulse shaping due to the modulation of an IR pulse in macroscopic systems

Haohan Shi, Yu He, Youda Wang, Zheng Fang et autres

Abstract Propagation effects are widely recognized as the origin of complex features observed in macroscopic absorption spectra. Here, we examine the evolution of spectral reshaping driven by laser-imposed initial phase modulation during pulse propagation. We present an analytical framework that elucidates the …

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Seminal plasma proteomics of asymptomatic COVID-19 patients reveals disruption of male reproductive function

Jialyu Huang, Yufang Su, Jiawei Wang, Zheng Fang et autres

BACKGROUND: A considerable proportion of males suffer from asymptomatic SARS-CoV-2 infection, while the effect on reproductive function and underlying pathomechanisms remain unclear. RESULTS: The total sperm count decreased evidently after asymptomatic infection, yet all semen samples were tested to be SARS-CoV-2 RNA …

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PELSA-Decipher: a software tool for the processing and interpretation of ligand-protein interaction dataset acquired by PELSA

Haiyang Zhu, Keyun Wang, Kejia Li, Zheng Fang et autres

Abstract Knowledge of protein-ligand interactions is essential for comprehending various aspects of life science, including drug mechanisms of action, regulatory processes in cellular metabolism and signaling, etc. Recently, a robust ligand modification-free method, termed as peptide-centric local stability assay (PELSA), is developed …

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[The role of tumor-associated macrophages in the development and progression of cervical cancer].

Siyi Mao, Zheng Fang, Yiming Xu, Kun Yang et autres

Cervical cancer (CC) has been a hot topic in the field of gynecological cancer due to its high morbidity and mortality. As one of the major components, tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), differentiating into M1 …

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Hitless two-dimensional focal plane switch array based on Mach-Zehnder interferometer-embedded micro-ring resonators

Zichao Zhao, Zeyu Yu, Qishen Liang, Zhaoyang Zhang et autres

Empowered by compact micro-ring (MRR) arrays, wavelength-division-multiplexing (WDM)-based focal plane switch array (FPSA) chip is a promising solution for light detection and ranging (LiDAR) due to its parallelism and high-level integration. However, an MRR channel with a shifting central wavelength may interrupt …

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IL-33 released during challenge phase regulates allergic asthma in an age-dependent way

Hangyu Liu, Min Wu, Qiangqiang Wang, Liuchuang Gao et autres

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Mitoxantrone ameliorates ineffective erythropoiesis in a β-thalassemia intermedia mouse model

Haihang Zhang, Rui Liu, Zheng Fang, Ling Nie et autres

ABSTRACT: β-thalassemia is a condition characterized by reduced or absent synthesis of β-globin resulting from genetic mutations, leading to expanded and ineffective erythropoiesis. Mitoxantrone has been widely used clinically as an antitumor agent considering its ability to inhibit cell proliferation. However, its …

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Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice

Zheng Fang, Jiaqin Mao, Jialyu Huang, Huijun Sun et autres

OBJECTIVE: Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN-γ levels leading to a pro-inflammatory cytokine milieu, which contributes to RPL pathogenesis. The main objective of this study was twofold: first to …

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TSG6‐Exo@CS/GP Attenuates Endometrium Fibrosis by Inhibiting Macrophage Activation in a Murine IUA Model

H. Sun, Jie Dong, Zhaoyue Fu, Xueyan Lu et autres

Intrauterine adhesion (IUA) is characterized by the formation of fibrous scar tissue within the uterine cavity, which significantly impacts female reproductive health and even leads to infertility. Unfortunately, severe cases of IUA currently lack effective treatments. This study presents a novel approach …

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Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation

Jialyu Huang, Zheng Fang, Xingwu Wu, Leizhen Xia et autres

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