Xueyan Lu

Advances in vibration therapy for the treatment of osteoporosis

Xueyan Lu, Haoyang Duan

Osteoporosis is a systemic skeletal disease characterized by reduced bone density and degeneration of bone microstructure. It is prevalent among postmenopausal women and elderly individuals. Current treatments face challenges such as drug side effects, low adherence, and comorbidities. Vibration therapy, as a …

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High concentration of estrogen resulted by COH may affect the secretion of pro-angiogenic factors in uNK cells by downregulating the expression of IL-11 in decidual stromal cells

Hui Mu, Haikun Yu, Song Yan, Jie Lu et autres

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Optimal cut-off values of visceral fat area for predicting metabolic syndrome among patients with ischemic stroke: a cross-sectional study

Xueyan Lu, Jing Wang, Huijie Sun, Dandan Liu et autres

Objectives The prevalence of metabolic syndrome (MetS) among patients with ischemic stroke is relatively high. The visceral fat area (VFA) is a predictor of MetS. This study aimed to estimate sex-specific optimal cut-off values of VFA and MetS risk factors among patients …

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Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice

Zheng Fang, Jiaqin Mao, Jialyu Huang, Huijun Sun et autres

OBJECTIVE: Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN-γ levels leading to a pro-inflammatory cytokine milieu, which contributes to RPL pathogenesis. The main objective of this study was twofold: first to …

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TSG6‐Exo@CS/GP Attenuates Endometrium Fibrosis by Inhibiting Macrophage Activation in a Murine IUA Model

H. Sun, Jie Dong, Zhaoyue Fu, Xueyan Lu et autres

Intrauterine adhesion (IUA) is characterized by the formation of fibrous scar tissue within the uterine cavity, which significantly impacts female reproductive health and even leads to infertility. Unfortunately, severe cases of IUA currently lack effective treatments. This study presents a novel approach …

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High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes

Xueyan Lu, Jiaqin Mao, Chenxi Qian, Hui Lei et autres

BACKGROUND: Ovarian stimulation (OS) during assisted reproductive technology (ART) appears to be an independent factor influencing the risk of low birth weight (LBW). Previous studies identified the association between LBW and placenta deterioration, potentially resulting from disturbed genomic DNA methylation in oocytes …

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Identifying a panel of nine genes as novel specific model in endometriosis noninvasive diagnosis

Danjie Su, Yongdong Guo, Rui Yang, Zheng Fang et autres

OBJECTIVE: To study biomarkers to develop a novel diagnosis model for endometriosis and validate it using clinical samples. DESIGN: We used publicly available data sets and weighted gene coexpression network analysis to identify differentially expressed genes. Ten machine learning algorithms were used …

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S31 Efficacy of dupilumab in chronic obstructive pulmonary disease with type 2 inflammation by baseline blood eosinophil count

Mona Bafadhel, Surya Prakash Bhatt, Klaus F. Rabe, NA Hanania et autres

Rationale Chronic obstructive pulmonary disease (COPD) is characterized by progressive lung function decline and worsening symptoms, accelerated by recurrent exacerbations. Type 2 (T2) inflammation may play a significant role in a subset of patients with COPD. Dupilumab, a fully human monoclonal antibody, …

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Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis

Fei Mu, Rui Lin, Xueyan Lu, Meina Zhao et autres

Context Styrax is used for prevention and treatment of cerebrovascular diseases. However, the underlying mechanism remains unclear.Objective To elucidate styrax’s anti-ischemic stroke protective effects and underlying mechanisms.Materials and methods An ischemic-stroke rat model was established based on middle cerebral artery occlusion (MCAO). …

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Generalised bullous fixed drug eruption induced by a topical plaster with Chinese herbs

Ya‐zhi Zhang, Yi‐meng Wang, Xueyan Lu, Dong‐ming Li et autres

The authors declare no potential conflict of interests.

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Effectiveness and Safety of Early Short-Course, Moderate- to High-Dose Glucocorticoids for the Treatment of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: A Retrospective Study

Zhenzhen Ye, Chunting Li, Hua Zhang, Chunlei Zhang et autres

Objective: To summarise the clinical characteristics of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis syndrome (SJS/TEN) and analyse the efficacy and safety of systemic glucocorticoid therapy. Methods: This study was a retrospective study of 56 patients with SJS/TEN who had been systematically treated …

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Primary Kaposi’s Sarcoma of the Nasal Cavity: Clinical Experience and Review of the Literature

Peng Xiang, Mengya Liu, Xueyan Lu, Wei Tang et autres

Kaposi's sarcoma (KS) is a vascular sarcoma derived from vascular endothelial cells and presents with multiple lesions. It mainly appears on the skin and oral mucosa, usually in the face, oral mucosa, and genitals. Very few cases of primary lesions in the …

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