Zhaoyue Fu

Eggshell-derived amorphous calcium phosphate for upcycled bone repair: An In-Vivo study

Kristaps Rubenis, Xin He, Öznur Demir, Zhaoyue Fu et autres

Critical-sized bone defects require grafting materials that support early osteogenesis and predictable defect bridging. In this study, we evaluated eggshell-derived amorphous calcium phosphate (ACP) granules in a rat calvarial defect model and compared them with ACP obtained from commercial hydroxyapatite (HAp) and …

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Sustainable Eggshell-Based Amorphous Calcium Phosphate Scaffolds and Membrane Protein Hydrogel for Regeneration in Rabbit Femoral and Calvarial Defects

Qianli Ma, Katrin Anja Staudigel, Kristaps Rubenis, Zhaoyue Fu et autres

High Resolution Image Download MS PowerPoint Slide Critical-sized bone defects require grafts with ideal spatial supporting. We upcycled eggshell waste sustainably into porous amorphous calcium phosphate (ACP) scaffolds and evaluated their early bone-regeneration performance alone and in combination with flexible and bioactive …

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Mechanistic insights into IL-6-mediated NK cell dysfunction in NSCLC via the IRE1α-XBP1s-STAT3-UBE2S axis

Yazhen Wang, Zichan Guo, Anqi Xu, Zhaoyue Fu et autres

Natural killer (NK) cell immunotherapy exhibits limited efficacy in non-small cell lung cancer (NSCLC) due to the suppressive tumor-associated immune microenvironment. Previous studies have shown that interleukin-6 (IL-6) contributes to NK cell dysfunction and decreases NKp30 expression. However, the underlying mechanisms warrant …

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Thermosensitive hydrogel loading ADSCs-derived exosomes with CD47 blocking ameliorates peri-implantitis via reinforcing macrophage reprogramming

Xutao Chen, Jie Dong, Zhaoyue Fu, Liu Yang et autres

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Inhibition of IRE1α Alleviates Renal Fibrosis and Downregulates M1 Macrophage Activation via the p38 MAPK Pathway

Zichan Guo, Yuting Shen, Xiaxia Yu, Jiyang Zheng et autres

The enhanced M1 macrophage activation and proportion significantly promote the progression of renal fibrosis in the unilateral ureteral obstruction (UUO) model, while the underlying mechanisms need to be further studied. Here, we examined whether or not endoplasmic reticulum (ER) stress contributed to …

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Mechanistic Insights into IL-6-Mediated NK Cell Dysfunction in NSCLC via the IRE1α-XBP1s-STAT3-UBE2S Axis

Yazhen Wang, Zichan Guo, Anqi Xu, Zhaoyue Fu et autres

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The effects of different cryopreservation forms on the detection of RNA in PBMC and plasma from rhesus monkeys and humans

Ruiyan Liu, Wenjin Xi, Yuanjie Sun, Yongli Hou et autres

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CD226 promotes renal fibrosis by regulating macrophage activation and migration

Yun Song, Yazhen Wang, Juan Li, Yuting Shen et autres

It has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral …

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TSG6‐Exo@CS/GP Attenuates Endometrium Fibrosis by Inhibiting Macrophage Activation in a Murine IUA Model

H. Sun, Jie Dong, Zhaoyue Fu, Xueyan Lu et autres

Intrauterine adhesion (IUA) is characterized by the formation of fibrous scar tissue within the uterine cavity, which significantly impacts female reproductive health and even leads to infertility. Unfortunately, severe cases of IUA currently lack effective treatments. This study presents a novel approach …

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CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ ‐induced diabetic mice

Yongli Hou, Yazhen Wang, Kang Tang, Yan Yang et autres

Abstract Diabetic cardiomyopathy (DCM) is one of the main complications in type I diabetic patients. Activated macrophage is critical for directing the process of inflammation during the development of DCM. The present study focused on the roles of CD226 on macrophage function …

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CD226 promotes renal fibrosis by regulating macrophage activation and migration

Yazhen Wang, Juan Li, Yuting Shen, Yongli Hou et autres

It has been found that CD226 plays an important role in regulating macrophage function, but its expression and function on macrophage during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the UUO …

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TiO2 nanostructured implant surface-mediated M2c polarization of inflammatory monocyte requiring intact cytoskeleton rearrangement

Zhaoyue Fu, Yongli Hou, Håvard Jostein Haugen, Xutao Chen et autres

BACKGROUND: Microgravity directly disturbs the reorganization of the cytoskeleton, exerting profound effects on the physiological process of macrophages. Although it has been established that macrophage M1/M2 polarization could be manipulated by the surface nanostructure of biomaterial in our previous study under normal …

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